Results 51 to 60 of about 26,900 (231)

Dual receptor T cells mediate effective antitumor immune responses via increased recognition of tumor antigens

Journal for ImmunoTherapy of Cancer, 2023
Background Discovery that ~16% of T cells naturally co-express two T-cell receptor (TCR) clonotypes prompts examining the role of dual TCR cells in immune functions.Methods Using TCRα-reporter transgenic mice, enabling unambiguous identification of ...
Lu Wang, Christine Caron, Gerald P Morris, Hyun J Jang, Calvin K Lee, Burhan Jama, Jack D Bui   +6 more
doaj   +1 more source

Biodegradable ion-exchange microspheres based on modified polylysines [PDF]

, 1995
Poly-L-lysine was synthesized via a triethylamine initiated ring-opening polymerization of Z-L-lysine-N'~-carboxyanhydride,\ud followed by deprotection of the E-amino group. Subsequently the polylysine was sulfamated using a pyridinium-sulfate complex to
Cremers, H.F.M., Feijen, J., Lens, J.P., Seymour, L.   +3 more
core   +4 more sources

B Cells Promote Tumor Immunity against B16F10 Melanoma [PDF]

The American Journal of Pathology, 2014
B cells are known to be critical mediators of tumor immunity; however, the mechanisms through which they exert this function remain unclear. B-cell linker protein (BLNK) is an essential component of the B-cell antigen receptor signaling machinery and is required for B-cell development, as evidenced by BLNK-deficient (BLNK(-/-)) mice, in which the ...
Tadahiro, Kobayashi, Yasuhito, Hamaguchi, Minoru, Hasegawa, Manabu, Fujimoto, Kazuhiko, Takehara, Takashi, Matsushita   +5 more
openaire   +2 more sources

Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development [PDF]

, 2017
published_or_final_versio
Guan, X, Huang, XR, Lain, GY, Lan, HY, Li, CJ, Meng, XM, Tang, PM, Tang, YJ, To, KF, Wang, QM, Yan, BP, Zhou, S   +11 more
core   +5 more sources

Immunotherapy-induced antibodies to endogenous retroviral envelope glycoprotein confer tumor protection in mice.

PLoS ONE, 2021
Following curative immunotherapy of B16F10 tumors, ~60% of mice develop a strong antibody response against cell-surface tumor antigens. Their antisera confer prophylactic protection against intravenous challenge with B16F10 cells, and also cross-react ...
Byong H Kang, Noor Momin, Kelly D Moynihan, Murillo Silva, Yingzhong Li, Darrell J Irvine, K Dane Wittrup   +6 more
doaj   +1 more source

Enhancement of electroporation facilitated immunogene therapy via T-reg depletion [PDF]

, 2014
Regulatory T cells (T-regs) can negatively impact tumor antigen-specific immune responses after infiltration into tumor tissue. However, depletion of T-regs can facilitate enhanced anti-tumor responses, thus augmenting the potential for immunotherapies ...
A Testori, AMM Eggermont, C Collins, D Alston, D M Soden, F Erdmann, F Tas, G C O' Sullivan, G Tevz, I Martínez-Lacaci, JFM Jacobs, L Finn, L Heller, L J Hall, M de Kruijf, M Sadadcharam, M Tangney, MC Whelan, MC Whelan, ML Lucas, P F Forde, R Dummer, S Bhatia, T R O' Donovan, TJ Curiel, TR Wilson, W L Byrne, W Zou, W Zou   +28 more
core   +1 more source

CXCL10 promotes melanoma angiogenesis and tumor growth

Animal Cells and Systems
Upregulation of CXC motif chemokine 10 (CXCL10) in melanoma patients has been found to be associated with melanoma progression. However, the role of endogenous CXCL10 from the host in melanoma tumor growth remains unclear.
Bongjun Kim, Yun-Yong Park, Jong-Ho Lee
doaj   +1 more source

Temporally Programmed CD8α+ DC Activation Enhances Combination Cancer Immunotherapy [PDF]

, 2016
Numerous synergistic cancer immunotherapy combinations have been identified, but the effects of relative dose timing are rarely considered. In established syngeneic mouse tumor models, we found that staggering interferon-α (IFNα) administration after ...
Irvine, Darrell J., Kauke, Monique J., Kelly, Ryan L., Mehta, Naveen, Moynihan, Kelly D., Opel, Cary F., Overwijk, Willem W., Szeto, Gregory L., Tzeng, Alice, Wittrup, K. Dane, Yang, Nicole J., Zhu, Eric F.   +11 more
core   +1 more source

Cystatin C Peptide Effects on B16F10 Melanoma Cells

CellBio, 2021
Background: Metastasis is a major problem for effective therapy of cancer. Small cysteine protease inhibitors, cystatins have been shown to be anti-metastatic for a number of different cancers. We have identified a small peptide of cystatin which exhibits anti-cancer properties for B16 melanoma cells in vitro.
Mathieu Hill, James L. Cox
openaire   +2 more sources

Inclusion of ΑVβ3 integrin into extracellular vesicles in a caveolin-1 tyrosine-14- phosphorylation dependent manner and subsequent transfer to recipient melanoma cells promotes migration, invasion and metastasis

Cell Communication and Signaling
Caveolin-1 (CAV1) is a membrane protein that promotes migration, invasion and metastasis of cancer cells when phosphorylated on tyrosine-14 (Y14) by a cell intrinsic mechanism involving the activation of a novel Rab5-Rac1 signaling axis.
R. Huilcaman, A. Campos, P. Contreras, L. Simón, M. Varas-Godoy, F. Grünenwald, Baohai Shao, Jay Heinecke, L. Lobos-Gonzalez, L. Leyton, A. F. G. Quest   +10 more
doaj   +1 more source