Results 101 to 110 of about 26,900 (231)

Action of Carnosic Acid Against Melanoma: A Strategy for Selective Radiosensitization with Protection of Non-Tumoral Cells

Current Issues in Molecular Biology
Carnosic acid (CA) is a phenolic diterpene with high antioxidant activity that supports its radioprotective capacity. This study aims to determine whether the radiosensitizing effect of CA established in B16F10 melanoma cells also occurs in other melanin-
Amparo Olivares, Isabel de la Fuente, Daniel Gyingiri Achel, Ana María Mercado, José Antonio Garcia-Gamuz, María del Rosario Tudela, Miguel Alcaraz   +6 more
doaj   +1 more source

A novel mode of capping protein-regulation by Twinfilin [PDF]

, 2018
Cellular actin assembly is controlled at the barbed ends of actin filaments, where capping protein (CP) limits polymerization. Twinfilin is a conserved in vivo binding partner of CP, yet the significance of this interaction has remained a mystery.
Amarasinghe, Gaya K, Cooper, John A, Goode, Bruce L, Harris, Meghan T, Hilton, Denise M, Johnson, Britney, Johnston, Adam B, McConnell, Patrick, Simone, Avital   +8 more
core   +1 more source

Multi-responsive “turn-on” nanocarriers for efficient site-specific gene delivery in vitro and in vivo [PDF]

, 2016
This is an accepted manuscript of an article published by Wiley in Advanced Healthcare Materials on 25/09/2016, available online: https://doi.org/10.1002/adhm.201600710 The accepted version of the publication may differ from the final published version ...
Bang, Blanco, Brunner, Cai, Chen, Cheng, Choi, Choi, Chuang, Cully, Eliaz, Evans, Fang, Fleige, Franzmann, Grosse, Han, Hatakeyama, He, He, Huth, Jiang, Jiang, Kircheis, Kong, Kurosaki, Lee, Li, Liu, Maeda, Moghimi, Münch, Nomoto, Pack, Panagiotis, Park, Pearson, Peng, Platt, Rajan, Riddles, Saito, Shaheen, Stern, Suk, Tseng, Uthaman, Wagner, Wang, Wang, Wang, Xu, Yamada, Yang, Yao, Yu, Yue, Zhou   +57 more
core   +1 more source

The effects of vitamin B6 compounds on cell proliferation and melanogenesis in B16F10 melanoma cells

Oncology Letters, 2018
B16F10 murine melanoma cells are frequently used for the study of cancer and melanogenesis. The cells are usually cultured in Dulbecco's Modified Eagle Medium, with the addition of 20 µM pyridoxal (PL) or pyridoxine (PN) for vitamin B6. The difference between these vitamin B6 compounds is thought not to affect cell proliferation, whereas their ...
Taisuke, Matsuo, Aki, Fujiwara, Kazuhiro, Nakamura, Yasuyuki, Sadzuka   +3 more
openaire   +3 more sources

Cathepsin L increases invasion and migration of B16 melanoma [PDF]

, 2007
Background Most cancers express elevated protease levels which contribute to certain aspects of tumor behavior such as growth, metastatic spread, and angiogenesis.
Zhen Yang, James L Cox
core   +2 more sources

Antitumor Effects In Vitro and In Vivo and Mechanisms of Protection against Melanoma B16F10-Nex2 Cells By Fastuosain, a Cysteine Proteinase from Bromelia fastuosa

Neoplasia: An International Journal for Oncology Research, 2007
In the present work, the antitumor effect of fastuosain, a cysteine proteinase from Bromelia fastuosa, was investigated. In the intravenous model of lung colonization in C57BI/6 mice, fastuosain and bromelain injected intraperitoneally were protective ...
Carla A. Guimarães-Ferreira, Elaine G. Rodrigues, Renato A. Mortara, Hamilton Cabral, Fabiana A. Serrano, Ricardo Ribeiro-dos-Santos, Luiz R. Travassos   +6 more
doaj   +1 more source

Simple Modifications of Branched PEI Lead to Highly Efficient siRNA Carriers with Low Toxicity [PDF]

, 2008
Polymer carriers like PEI which proved their efficiency in DNA delivery were found to be far less effective for the applications with siRNA. In the current study, we generated a number of nontoxic derivates of branched PEI through modification of amines ...
Dehshahri, Ali, Philipp, Alexander, Wagner, Ernst, Zintchenko, Arkadi   +3 more
core   +1 more source

Development of a Safeguard System Using an Episomal Mammalian Artificial Chromosome for Gene and Cell Therapy

Molecular Therapy: Nucleic Acids, 2015
The development of a safeguard system to remove tumorigenic cells would allow safer clinical applications of stem cells for the treatment of patients with an intractable disease including genetic disorders.
Narumi Uno, Katsuhiro Uno, Shinya Komoto, Teruhiko Suzuki, Masaharu Hiratsuka, Mitsuhiko Osaki, Yasuhiro Kazuki, Mitsuo Oshimura   +7 more
doaj   +1 more source

Genistein induces a protective immunomodulatory effect in a mouse model of cervical cancer [PDF]

, 2012
Background: Genistein (GEN), a naturally occurring flavonoid present in soy bean, has attracted scientific interest for its possible benefits in cancer. Objective: The potential immunomodulatory effects of genistein on the immune system and against TC-1 ...
Alizadeh, A., Ghaemi, A., Gorji, A., Moradi, A., Razeghi, S., Soleimanjahi, H., Tabaraei, A., Vakili, M.A.   +7 more
core   +1 more source

Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution [PDF]

, 2014
Cytokine therapy can activate potent, sustained antitumor responses, but collateral toxicity often limits dosages. Although antibody–cytokine fusions (immunocytokines) have been designed with the intent to localize cytokine activity, systemic dose ...
Kwan, Byron Hua, Navaratna, Tejas, Opel, Cary Francis, Tzeng, Alice, Wittrup, Karl Dane   +4 more
core   +1 more source