Results 1 to 10 of about 343,349 (228)

The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen [PDF]

Blood, 1994
T-cell activation is initiated after T-cell receptor binding to antigen, but also requires interactions between costimulatory molecules expressed on antigen-presenting cells. An important costimulatory molecule expressed by monocytes and activated B lymphocytes has been recently identified and termed B7–2 or B70.
P, Engel, J G, Gribben, G J, Freeman, L J, Zhou, Y, Nozawa, M, Abe, L M, Nadler, H, Wakasa, T F, Tedder   +8 more
openaire   +4 more sources

Preclinical evaluation of antitumor activity and toxicity of TROP2-specific CAR-T cells for treatment of triple-negative breast cancer [PDF]

Journal for ImmunoTherapy of Cancer
Background Triple-negative breast cancer (TNBC) represents a subtype of breast cancer with poorest prognosis due to limited effective targeted therapies.
Lu Zhang, Li Yan, Yang Xu, Xiaojia Wang, Fei Wu, Shuqun Zhang, Shiyu Sun, Huizi Wu, Yongchen Chen, Ziwei Liang, Zuomin Nian, Wanni Xu, Wenzhou Wang, Yiwei Jia, Xingcong Ma   +14 more
doaj   +2 more sources

Role of CD86 (B7-2) in triggering of antigen-specific IgE antibody response by lipopolysaccharide [PDF]

FEMS Immunology and Medical Microbiology, 1998
The role of CD86 in triggering of ascaris extract-specific IgE antibody response by lipopolysaccharide was studied. The simultaneous administration of anti-CD86 antibody with ascaris extract and lipopolysaccharide prevented the production of IgE antibody response to ascaris extract.
G Z, Jiang, Y, Kato, T, Sugiyama, N, Koide, D, Chakravortty, M, Kawai, M, Fukada, T, Yoshida, T, Yokochi   +8 more
openaire   +3 more sources

Integrative molecular analyses define correlates of high B7-H3 expression in metastatic castrate-resistant prostate cancer

npj Precision Oncology, 2022
B7-H3 (CD276) is an immune checkpoint overexpressed in prostate cancer with minimal expression in normal tissues and associated with poor prognosis, making it an excellent therapy target.
Xiaolei Shi, Abderrahman Day, Hannah E. Bergom, Sydney Tape, Sylvan C. Baca, Zoi E. Sychev, Gabrianne Larson, Asha Bozicevich, Justin M. Drake, Nicholas Zorko, Jinhua Wang, Charles J. Ryan, Emmanuel S. Antonarakis, Justin Hwang   +13 more
doaj   +1 more source

Augmented Innate and Adaptive Immune Responses Under Conditions of Diabetes–Filariasis Comorbidity

Frontiers in Immunology, 2021
Metainflammation, as seen in chronic diabetes subjects, impairs immunity and increases the susceptibility to infections. In the present study, the effect of diabetes on immune response against filariasis was studied.
Joy Manohar Sibi, Viswanathan Mohan, Saravanan Munisankar, Subash Babu, Vivekanandhan Aravindhan   +4 more
doaj   +1 more source

The homodimer interfaces of costimulatory receptors B7 and CD28 control their engagement and pro-inflammatory signaling

Journal of Biomedical Science, 2023
Background The inflammatory response is indispensable for protective immunity, yet microbial pathogens often trigger an excessive response, ‘cytokine storm’, harmful to the host. Full T-cell activation requires interaction of costimulatory receptors B7-1(
Andrey Popugailo, Ziv Rotfogel, Michal Levy, Orli Turgeman, Dalia Hillman, Revital Levy, Gila Arad, Tomer Shpilka, Raymond Kaempfer   +8 more
doaj   +1 more source

Design of a novel multiepitope vaccine against Chlamydia pneumoniae using the extracellular protein as a target

Scientific Reports, 2023
Chlamydia pneumoniae (C. pneumoniae) infection in humans is universal and causes various respiratory infectious diseases, making a safe and effective preventive vaccine essential. In this study, a multi-epitope vaccine with CTLA-4 extracellular structure
Xiaomei Guo, Xiaohong Pan, Qiangming Sun, Yunzhang Hu, Jiandong Shi   +4 more
doaj   +1 more source

Bioinformatics-based design of a fusion vaccine with CTLA-4 variable region to combat Brucella

Brazilian Journal of Medical and Biological Research, 2023
Brucellosis has become a global zoonotic disease, seriously endangering the health of people all over the world. Vaccination is an effective strategy for protection against Brucella infection in livestock in developed countries. However, current vaccines
W.H. Guo, Y.J. Zhu, G. Haimiti, X.R. Xie, C. Niu, M. Li, J. Shi, Z.W. Yin, M.K. Yu, J.B. Ding, F.B. Zhang   +10 more
doaj   +1 more source

Inhibition of colorectal cancer targets IL-6, CTLA-4, & B7-2 by Tislelizumab: molecular docking, dynamics, & STRING protein-protein network analysis

Informatics in Medicine Unlocked, 2023
As a DNA mismatch repair deficit (dMMR) anticancer medication, and a humanized monoclonal antibody (hmAb), Tislelizumab has attracted significant interest in recent years.
Mahmoud Elkazzaz, Shahid Ullah, Tianshun Gao, Israa M. Shamkh, Amr Ahmed, Ted X. Wu, Maii S. Elsharayidi, Mohammad Shahbaz Khan, Aziz-ur Rehman, Marwa M. Lotfy, Abdullah Haikal, Mahmoud Abdalrahman   +11 more
doaj   +1 more source

CNS expression of B7-H1 regulates pro-inflammatory cytokine production and alters severity of Theiler's virus-induced demyelinating disease. [PDF]

PLoS ONE, 2011
The CNS is a unique organ due to its limited capacity for immune surveillance. As macrophages of the CNS, microglia represent a population originally known for the ability to assist neuronal stability, are now appreciated for their role in initiating and
D'Anne S Duncan, Stephen D Miller
doaj   +1 more source