Results 21 to 30 of about 343,349 (228)
Indirect recruitment of a CD40 signaling pathway in dendritic cells by B7-DC cross-linking antibody modulates T cell functions. [PDF]
PLoS ONE, 2009 The human IgM B7-DC XAb protects mice from tumors in both therapeutic and prophylactic settings. Its mechanism of action is mediated by its binding to B7-DC/PD-L2 molecules on the surface of dendritic cells (DCs) to induce a multimolecular cap and ...
Suresh Radhakrishnan +6 more
doaj +1 more source
Frontiers in Oncology, 2021 PurposeThe aim of this study was to characterize chondrosarcoma tumor infiltration by immune cells and the expression of immunologically relevant molecules.
Sjoerd P. F. T. Nota +16 more
doaj +1 more source
Primary human mesothelioma cells express class II MHC, ICAM-1 and B7–2 and can present recall antigens to autologous blood lymphocytes [PDF]
International Journal of Cancer, 1998 Mesothelioma cells (MMc) are considered to be weakly immunogenic and the experimental approaches attempting to induce an immune response against these cells have been disappointing. Our aim was to investigate whether MMc possess the surface accessory molecules involved in antigen presentation and whether these cells are capable of presenting recall ...
Mutti L. +8 more
openaire +3 more sources
CD154–CD40‐independent up‐regulation of B7‐2 on splenic antigen‐presenting cells and efficient T cell priming by staphylococcal enterotoxin A [PDF]
International Immunology, 2003 It has been demonstrated that in vivo T cell priming requires CD154-CD40 interaction, which is suggested to be critical in the induction of co-stimulatory activities on antigen-presenting cells (APC). In the current study, we demonstrate that in vivo administration of a high dose of a superantigen, staphylococcal enterotoxin A (SEA), could up-regulate ...
Koji, Eshima +2 more
openaire +2 more sources
EBioMedicine, 2019 Background: The dismal survival of glioblastoma (GBM) patients urgently calls for the development of new treatments. Chimeric antigen receptor T (CAR-T) cells are an attractive strategy, but preclinical and clinical studies in GBM have shown that ...
Dean Nehama +16 more
doaj +1 more source
Respiratory Research, 2011 Background Type II alveolar epithelial cells (AECII) are well known for their role in the innate immune system. More recently, it was proposed that they could play a role in the antigen presentation to T lymphocytes but contradictory results have been ...
Remmelink Myriam +5 more
doaj +1 more source
Scientific Reports, 2023 Advanced hepatic fibrosis occurs in up to 25% of individuals with C282Y homozygous hemochromatosis. Our aim was to determine whether human leukocyte antigen (HLA)-A3 and B7 alleles act as genetic modifiers of the likelihood of advanced hepatic fibrosis ...
John K. Olynyk +4 more
doaj +1 more source
Prevention of CD8 T Cell Deletion during Chronic Viral Infection
Viruses, 2021 During chronic viral infections, CD8 T cells rapidly lose antiviral and immune-stimulatory functions in a sustained program termed exhaustion. In addition to this loss of function, CD8 T cells with the highest affinity for viral antigen can be physically
David G. Brooks +3 more
doaj +1 more source
Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80(dim), CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients [PDF]
, 1996 We have shown previously that granulocyte-macrophage colony-stimulating factor-stimulated mouse bone marrow-derived MHC class II+ dendritic cell (DC) progenitors that are deficient in cell surface expression of the costimulatory molecules B7-1 (CD8O) and
Angus W. Thomson +48 more
core +1 more source
Clinical and Developmental Immunology, 2012 Background. Low expression or absence of dendritic cell (DC) surface B7 molecules can induce immune tolerance or hyporesponse. Whether DCs could induce indirect allogeneic-specific cross-tolerance or hyporesponse to recipient T cells remains unclear ...
Yu-Feng Yao +4 more
doaj +1 more source