Results 91 to 100 of about 5,084 (185)

The tumor necrosis factor receptor superfamily in lung cancer immunotherapy: Therapeutic opportunities and challenges

Precision Medical Sciences, Volume 15, Issue 1, Page 18-28, March 2026.
TNFRSF members orchestrate a dynamic immunoregulatory network in lung cancer by coordinating co‐stimulatory and inhibitory signaling across immune cell populations, highlighting their potential as targets for precision immunotherapy. Abstract Immune checkpoint blockade has fundamentally reshaped the therapeutic landscape of lung cancer.
Bingjie Xue, Liling Dai, Li Dai, Xianglin Zuo   +3 more
wiley   +1 more source

B and T Lymphocyte Attenuator is a Target of miR-155 during Naive CD4+ T Cell Activation [PDF]

Iranian Journal of Immunology, 2016
Background: MicroRNA-155 (miR-155) is upregulated during T cell activation, but the exact mechanisms by which it influences CD4+ T cell activation remain unclear.
Yongan Liu, Wei Nie, Yu Jin, Anshan Zhuo, Yuansheng Zang, Qingyu Xiu   +5 more
doaj  

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Protein tyrosine phosphatases as emerging targets for cancer immunotherapy

British Journal of Pharmacology, Volume 183, Issue 6, Page 1233-1249, March 2026.
Abstract Contemporary strategies in cancer immunotherapy, despite remarkable success, remain constrained by inherent limitations such as suboptimal patient responses, the emergence of drug resistance, and the manifestation of pronounced adverse effects. Consequently, the need for alternative strategies for immunotherapy becomes clear.
Zihan Qu, Jiajun Dong, Zhong‐Yin Zhang
wiley   +1 more source

Decreased B and T lymphocyte attenuator in Behcet's disease may trigger abnormal Th17 and Th1 immune responses

, 2016
Behcet's disease (BD) is a chronic, systemic and recurrent inflammatory disease associated with hyperactive Th17 and Th1 immune responses. Recent studies have shown that B and T lymphocyte attenuator (BTLA) negatively regulates the immune response.
Wang, Chaokui, Yang, Peizeng, Zhang, Dike, Deng, Bolin, Ye, Zi, Kijlstra, Aize   +5 more
core   +1 more source

Dissection of BTLA Interactomes Using Cell Free Reconstitution [PDF]

, 2018
B and T lymphocyte attenuator (BTLA) is a co-inhibitory receptor expressed on T cells and B cells that is structurally and functionally related to programmed death protein-1 (PD-1), a well-established cancer immunotherapy target.
Wu, Zijun
core   +1 more source

BTLA biology in cancer: from bench discoveries to clinical potentials

Biomarker Research
Immune checkpoints play a critical role in maintaining the delicate balance of immune activation in order to prevent potential harm caused by excessive activation, autoimmunity, or tissue damage.
Anna Andrzejczak, Lidia Karabon
doaj   +1 more source

B and T Lymphocyte Attenuator Tempers Early Infection Immunity

Journal of Immunology, 2009
Coinhibitory pathways are thought to act in later stages of an adaptive immune response, but whether coinhibition contributes to early innate immunity is unclear.
Yong-Lian Sun, Nicholas K. Brown, Matthew J. Ruddy, Mendy Miller, Youjin Lee, Yang Wang, K. Murphy, K. Pfeffer, Lieping Chen, J. Kaye, Yang-Xin Fu   +10 more
semanticscholar   +1 more source

BTLA expression declines on B cells of the aged and is associated with low responsiveness to the trivalent influenza vaccine

, 2016
Virus-neutralizing antibody and B cell responses to influenza A viruses were measured in 35 aged and 28 middle-aged individuals following vaccination with the 2012 and 2013 trivalent inactivated influenza vaccines.
Freeman, Gordon, Doyle, Susan A., Schmader, Kenneth E., Kannan, Senthil, Kurupati, Raj K., Ertl, Hildegund C.J.   +5 more
core   +4 more sources

The Intrahepatic Expression and Distribution of BTLA and its Ligand HVEM in patients with HBV-related acute-on-chronic liver failure

Diagnostic Pathology, 2012
Objective It has been demonstrated that signals from the inhibitory receptor B and T lymphocyte attenuator (BTLA) are involved in regulating the pathogenesis of infectious diseases.
Xu Huan, Cao Dayan, Guo Guoning, Ruan Zhihua, Wu Yuzhang, Chen Yongwen   +5 more
doaj   +1 more source