Results 101 to 110 of about 5,084 (185)

CpG-ODN-induced sustained expression of BTLA mediating selective inhibition of human B cells [PDF]

, 2018
BTLA (B- and T-lymphocyte attenuator) is a prominent co-receptor that is structurally and functionally related to CTLA-4 and PD-1. In T cells, BTLA inhibits TCR-mediated activation.
Gertner-Dardenne, Julie, Derré, Laurent, Olive, Daniel, Rivals, Jean-Paul, Speiser, Daniel, Mamessier, Emilie, Pastor, Sonia, Thibult, Marie-Laure   +7 more
core  

Defective BTLA functionality is rescued by restoring lipid metabolism in lupus CD4+ T cells

, 2018
International audienceCoinhibitory receptors play an important role in the prevention of autoimmune diseases, such as systemic lupus erythematosus (SLE), by limiting T cell activation.
Sagez, Flora, Dumortier, Hélène, Gottenberg, Jacques-Eric, Fauny, Jean-Daniel, Sawaf, Matthieu, Monneaux, Fanny, Felten, Renaud   +6 more
core   +1 more source

B- and T-Lymphocyte Attenuator Targeting Protects Against the Acute Phase of Graft Versus Host Reaction by Inhibiting Donor Anti-Host Cytotoxicity

[EN] Background. B-and T-lymphocyte attenuator (BTLA) functions as a coinhibitory/costimulatory molecule that belongs to the immunoglobulin superfamily and exhibits a pattern of expression restricted to the hematopoietic compartment.
Pérez Martínez, Claudia, Río González, María Luisa del, Ghosh, Arnab, Kurtz, Josef, Rodríguez Barbosa, José Ignacio, Pérez Simón, José Antonio   +5 more
core   +1 more source

Altered BTLA expression and function in lymphocytes during lupus: consequences for therapeutic targeting

, 2023
International audienceB and T lymphocyte attenuator (BTLA) is a co-inhibitory receptor expressed by lymphoid cells that negatively regulates the immune response.
Gherardi, Léa, Dumortier, Hélène, Monneaux, Fanny   +2 more
core   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

PD-1 et BTLA au coeur des lymphocytes B : du physiologique aux lymphomes

, 2011
La réponse immunitaires est régulée par des molécules de co-signalisation, qui, en apportant des signaux inhibiteurs ou activateurs, modulent les fonctions lymphocytaires.
Thibult, Marie-Laure
core  

Stimulation of the Co-inhibitory BTLA Pathway Protects Against Atherosclerosis by Selectively Reducing Atherogenic B Cells

, 2018
B-and T-lymphocyte attenuator (BTLA) is a co-inhibitory molecule which was identified as a marker for Th1 cells. However, nowadays it is known that BTLA is most abundantly expressed on B cells. Also, we showed earlier that BTLA was specifically expressed
Schaftenaar, F.H., Jacob Amersfoort, Kuiper, J., Johan Kuiper, Hidde Douna, Amanda Foks, Gijs van Puijvelde, Frank Schaftenaar, Puijvelde, G.H.M. van, Amersfoort, J., Foks, A.C., Douna, H.   +11 more
core   +1 more source

Mutant HVEM in lymphoma disrupts BTLA and CD160 regulation of anti-tumor signaling

Frontiers in Immunology
IntroductionSomatic mutations can rewire tumor–immune interactions to favor cancer progression. Here, we define the functional impact of missense mutations in Herpesvirus entry mediator (HVEM, TNFRSF14), a receptor frequently altered in lymphoma and ...
Wai Wai Lin, Sarah Huang, Olivia Balmert, Ryan Bjordahl, Brian C. Ware, Aref Moshayedi, Jennifer Nguyen, Carl F. Ware, John R. Šedý   +8 more
doaj   +1 more source

B and T Lymphocyte Attenuator Regulates B Cell Receptor Signaling by Targeting Syk and BLNK

Journal of Immunology, 2009
Andrew C. Vendel, Jill Calemine-Fenaux, A. Izrael-Tomasevic, V. Chauhan, D. Arnott, D. Eaton   +5 more
semanticscholar   +1 more source