Results 81 to 90 of about 5,084 (185)

B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients

Critical Care, 2013
IntroductionSepsis is a deadly inflammatory condition that often leads to an immune suppressed state; however, the events leading to this state remain poorly understood.
Nicholas J. Shubin, S. Monaghan, Daithi S. Heffernan, C. Chung, A. Ayala   +4 more
semanticscholar   +1 more source

B and T lymphocyte attenuator regulates autophagy in mycobacterial infection via the AKT/mTOR signal pathway.

International Immunopharmacology, 2020
The survivability of Mycobacterium tuberculosis (M.tb) in macrophages in granuloma is a predominant cause for tuberculosis (TB) infection and recurrence. However, the mechanism of mycobacterial clearance in macrophages still needs further study. Here, we
Jiao Liu, Siqi Ming, Weifeng Song, Xiaojun Meng, Qiang Xiao, Minhao Wu, Yong-Jian Wu, Hanbin Xie, Jie Zhou, Haibo Zhong, Xi Huang   +10 more
semanticscholar   +1 more source

Immunotherapy in Thyroid Cancer: Current Strategies and Challenges

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Thyroid cancer is the most common endocrine malignancy, with an increasing global incidence. Despite advances in conventional treatments, such as surgery, radioactive iodine therapy, and TSH suppression, the management of advanced and aggressive forms, such as anaplastic thyroid carcinoma and refractory differentiated thyroid carcinoma ...
Qian Zhang, Fan Wang, Wenbin Ma, Nan Liu, Yihan Lu, Ping Zhang   +5 more
wiley   +1 more source

B‐ and T‐Lymphocyte Attenuator in Systemic Lupus Erythematosus Disease Pathogenesis

Clinical pharmacology and therapy
B‐ and T‐lymphocyte attenuator (BTLA; CD272) is an immunoglobulin superfamily member and part of a family of checkpoint inhibitory receptors that negatively regulate immune cell activation. The natural ligand for BTLA is herpes virus entry mediator (HVEM;
Andrew C. Vendel, L. Jaroszewski, Matthew D. Linnik, A. Godzik   +3 more
semanticscholar   +1 more source

Harnessing Tumor Organoids to Revolutionize Immunotherapy Research

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Immunotherapy has emerged as a revolutionary approach to cancer treatment, yet the lack of robust preclinical testing platforms impedes progress in this field. Tumor organoids, three‐dimensional structures derived from patient‐specific samples, differ from conventional models by faithfully recapitulating the histological, genetic, and ...
Zhen Wang, Peipei Yin, Shizhan Cui, Hui Liu, Dan Li, Yang Yu, Baoshan Cao, Xiaojuan Liu   +7 more
wiley   +1 more source

A BTLA-Mediated Bait and Switch Strategy Permits Listeria Expansion in CD8α+ DCs to Promote Long-Term T Cell Responses [PDF]

, 2014
SummaryListeria monocytogenes infected CD8α+ DCs in the spleen are essential for CD8+ T cell generation. CD8α+ DCs are also necessary for Listeria expansion and dissemination within the host.
Tu, Tony, Tony Tu, Zhang, Xunmin, Yang-Xin Fu, Xuanming Yang, Yonglian Sun, Miller, Mendy, Fu, May Lynne, Sun, Yonglian, Fu, Yang-Xin, Mendy Miller, Yang, Xuanming, Xunmin Zhang, May Lynne Fu   +13 more
core   +1 more source

Genetic Alterations Involved in Immune Escape Mechanisms of Circulating Tumour Cells in Colorectal Carcinogenesis

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT In colorectal cancer (CRC), circulating tumour cells (CTCs) employ genetic alterations to dodge the body's immune system. These alterations occur in specific “driver” genes, including KRAS, BRAF, p53, MYC, APC and PTEN. Changes in these genes can control how the tumour interacts with the immune system and influence the expression of immune ...
Sharmin Aktar, Matthew Masoudi, Dilpreet Moti, Vinod Gopalan, Farhadul Islam, Alfred King‐yin Lam   +5 more
wiley   +1 more source

Immunotherapy in Advanced Gastric Cancer: Advancing Precision Medicine and Emerging Therapeutic Strategies

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
Immunotherapy has evolved into a pivotal therapeutic approach for advanced gastric cancer, encompassing immune checkpoint inhibitors as monotherapy, as well as combination strategies with chemotherapy, targeted therapy, and dual‐specific checkpoint antibodies.
Li Zhang, Qihua Zhang, Xueliang Zhang, Aihong Mao, Yuhua Liu, Huiyan Luo   +5 more
wiley   +1 more source

The Inhibitory Receptor B and T Lymphocyte Attenuator Controls γδ T cell Homeostasis and Inflammatory Responses

Immunity, 2013
SUMMARY γδ T cells rapidly secrete inflammatory cytokines at barrier sites that aid in protection from pathogens, however mechanisms limiting inflammatory damage remain unclear.
V. Bekiaris, J. Sedy, Matthew G. Macauley, Antje Rhode-Kurnow, C. Ware   +4 more
semanticscholar   +1 more source

BTLA exhibits immune memory for αβ T cells in patients with active pulmonary tuberculosis [PDF]

, 2014
Despite past extensive studies, the role of B and T lymphocyte attenuator (BTLA) in αβ T cells in patients with active pulmonary tuberculosis (ATB) remains poorly understood. Here we demonstrate that BTLA expression on αβ T cells is decreased in patients
D-Z Lin (7946807), W-D Wang (7946816), G-B Lui (7946813), L-L Yi (7946810), J-C Zeng (7946804), H. Zhang (537656), J-A Zhang (7946819)   +6 more
core   +3 more sources