Results 61 to 70 of about 5,084 (185)

Allosteric regulation of binding specificity of HVEM for CD160 and BTLA ligands upon G89F mutation

Current Research in Structural Biology, 2021
Molecular interactions mediated by engagement of the Herpes virus entry mediator (HVEM) with members of TNF and Ig superfamily generate distinct signals in T cell activation pathways that modulate inflammatory and inhibitory responses.
Rojan Shrestha, Sarah Garrett-Thomson, Weifeng Liu, Steven C. Almo, Andras Fiser   +4 more
doaj   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao, Jinxiu Qian, Qiqiong Liu, Wanting Ye, Ying Xing, Xiuyun Bai, Rongjun Deng, Jue Yang, Cheng Lu, Cheng Xiao, Yuanyan Liu   +10 more
wiley   +1 more source

Expression and clinical significance of B and T lymphocyte attenuator on CD4+ and CD8+ T cells from patients with pulmonary tuberculosis

Indian Journal of Pathology and Microbiology, 2019
Background: As an immune checkpoint, upregulation of B and T lymphocyte attenuator (BTLA) contributes to T-cell exhaustion in chronic infection. However, the characteristics of BTLA on T cells of patients with pulmonary tuberculosis (PTB) are still ...
Xinghua Shen, Jianping Zhang, Peijun Tang, Huafeng Song, Xiaocao Liu, Ziyi Huang, Xueguang Zhang, Xuefeng Wang, Meiying Wu   +8 more
doaj   +1 more source

Combination checkpoint therapy with anti-PD-1 and anti-BTLA results in a synergistic therapeutic effect against murine glioblastoma

OncoImmunology, 2021
Clinical trials involving anti-programmed cell death protein-1 (anti-PD-1) failed to demonstrate improved overall survival in glioblastoma (GBM) patients.
John Choi, Ravi Medikonda, Laura Saleh, Timothy Kim, Ayush Pant, Siddhartha Srivastava, Young-Hoon Kim, Christina Jackson, Luqing Tong, Denis Routkevitch, Christopher Jackson, Dimitrios Mathios, Tianna Zhao, Hyerim Cho, Henry Brem, Michael Lim   +15 more
doaj   +1 more source

Clinical Insights Into Novel Immune Checkpoint Inhibitors

Frontiers in Pharmacology, 2021
The success of immune checkpoint inhibitors (ICIs), notably anti-cytotoxic T lymphocyte associated antigen-4 (CTLA-4) as well as inhibitors of CTLA-4, programmed death 1 (PD-1), and programmed death ligand-1 (PD-L1), has revolutionized treatment options ...
Jii Bum Lee, Jii Bum Lee, Sang-Jun Ha, Hye Ryun Kim   +3 more
doaj   +1 more source

Human Cytomegalovirus Genetic Diversity, Clinical Relevance, and Emerging Insights

Reviews in Medical Virology, Volume 36, Issue 5, September 2026.
ABSTRACT Human cytomegalovirus (HCMV) is a globally prevalent virus that poses a significant public health concern, especially for newborns and immunocompromised patients, causing a wide range of infections. Clinical outcomes associated with HCMV infection include congenital disease, graft rejection in transplant recipients, and life‐threatening ...
Hajar Y. AlQahtani, Fadilah Sfouq Aleanizy, Fulwah Yahya Alqahtani   +2 more
wiley   +1 more source

B and T Lymphocyte Attenuator Restricts the Protective Immune Response against Experimental Malaria

, 2011
The immune response against the blood stage of malaria has to be tightly regulated to allow for vigorous antiplasmodial activity while restraining potentially lethal immunopathologic damage to the host like cerebral malaria.
Thomas Jacobs, Christiane Steeg, Theresa L. Murphy, Klaus Pfeffer, Guido Adler, Jean Langhorne, Kenneth M. Murphy   +6 more
core   +1 more source

Subset of DN Memory B Cells Expressing Low Levels of Inhibitory Receptor BTLA Is Enriched in SLE Patients

Cells
The dialogue between T and B cells can be regulated by different mechanisms, such as co-inhibitory receptors, which therefore play a crucial role in preventing autoimmune diseases such as systemic lupus erythematosus (SLE). B and T lymphocyte attenuator (
Lucie Aubergeon, Renaud Felten, Jacques-Eric Gottenberg, Hélène Dumortier, Fanny Monneaux   +4 more
doaj   +1 more source

Comparison of Human Melanoma Single Cell Profiles to Evolutionary Medicine Model Xiphophorus Provides Insights in Disease Control

Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.
Single‐nucleus RNA sequencing analysis of Xiphophorus melanoma, an evolutionary medicine model, revealed cellular heterogeneity that closely mirrors that of human melanoma. Immune and tumor cell subtyping identified an immune‐evasive tumor microenvironment. This melanoma cell atlas provides a framework for investigating conserved cellular and molecular
Yuan Lu, Will Boswell, Rachel Carroll, Maggs X, Yanting Xing, Wesley C. Warren, Manfred Schartl   +6 more
wiley   +1 more source