Results 51 to 60 of about 5,084 (185)

Distinct Changes of BTLA and HVEM Expressions in Circulating CD4+ and CD8+ T Cells in Hepatocellular Carcinoma Patients

Journal of Immunology Research, 2018
BTLA/HVEM (B and T lymphocyte attenuator/herpes virus entry mediator) pathways play a critical role in T cell suppression in tumor. However, its dynamic changes in different T cell subsets in peripheral blood and their clinical significance are largely ...
Jiayu Liu, Jiaqian Li, Min He, Geng-Lin Zhang, Qiyi Zhao   +4 more
doaj   +1 more source

BTLA-HVEM Couple in Health and Diseases: Insights for Immunotherapy in Lung Cancer

Frontiers in Oncology, 2021
Lung cancer is the leading cause of cancer deaths worldwide. Immunotherapies (IT) have been rapidly approved for lung cancer treatment after the spectacular results in melanoma.
Clemence Demerlé, Laurent Gorvel, Daniel Olive   +2 more
doaj   +1 more source

Mechanistic and Functional Characterization of B and T Lymphocyte Attenuator (Btla) In Cd8 Tumor Infiltrating Lymphocytes [PDF]

, 2016
This dissertation project focused on understanding the functional role of BTLA on CD8+ Tumor Infiltrating Lymphocytes (TIL) from metastatic melanoma patients.
ritthipichai, krit
core   +1 more source

The role of the B- and T-lymphocyte attenuator (BTLA) in T cell activation

, 2014
Die T-Zell-Aktivierung ist ein komplexer Prozess an dem viele Rezeptoren und Liganden beteiligt sind. Eine wichtige Aufgabe in diesem Prozess haben, neben dem antigenspezifischen Signal, die so genannten Kosignale.
Wildom, Bernhard
core   +2 more sources

B and T lymphocyte attenuator as a C-reactive protein and IgA associated auxiliary diagnostic marker for pulmonary tuberculosis: a case-control study

Annals of Translational Medicine, 2022
Background Screening and identification of hematologic molecular indicators of pulmonary tuberculosis (PTB) is crucial for its diagnose and therapy. Therefore, our work aims to detect the diagnostic value of blood marker B and T lymphocyte attenuator ...
Fei-Fan Xu, Keyun Bian, Shouwei Wang, Fan Yao, Jinling Chen, Yali Cao, Yong-Wei Qin   +6 more
semanticscholar   +1 more source

BTLA interaction with HVEM expressed on CD8(+) T cells promotes survival and memory generation in response to a bacterial infection.

PLoS ONE, 2013
The B and T lymphocyte attenuator (BTLA) is an Ig super family member that binds to the herpes virus entry mediator (HVEM), a TNF receptor super family (TNFRSF) member.
Marcos W Steinberg, Yujun Huang, Yiran Wang-Zhu, Carl F Ware, Hilde Cheroutre, Mitchell Kronenberg   +5 more
doaj   +1 more source

BTLA blockade enhances Cancer therapy by inhibiting IL-6/IL-10-induced CD19high B lymphocytes

Journal for ImmunoTherapy of Cancer, 2019
Background The standard treatment for epithelial ovarian carcinoma (EOC) is surgery followed by platinum/paclitaxel-based chemotherapy, but the overall survival rate is poor.
Yu-Li Chen, Han-Wei Lin, Chung-Liang Chien, Yen-Ling Lai, Wei-Zen Sun, Chi-An Chen, Wen-Fang Cheng   +6 more
doaj   +1 more source

The prospective prognostic value of the immune checkpoint BTLA expression in adult acute myeloid leukemia patients

Egyptian Journal of Medical Human Genetics, 2021
Background One of the crucial functions of the immune system is to prevent tumorigenesis, yet cancer occurs when malignant cells manage to evade immune surveillance via multiple strategies.
Sara M. Radwan, Nooran S. Elleboudy, Nermeen A. Nabih, Amal El-kholy, Amany M. Kamal   +4 more
doaj   +1 more source

Dual inhibition of BTLA and PD-1 can enhance therapeutic efficacy of paclitaxel on intraperitoneally disseminated tumors

Journal for ImmunoTherapy of Cancer, 2023
Background Expression of immune checkpoints in the tumor microenvironment is one mechanism underlying paclitaxel (PTX) chemoresistance. This study aimed to investigate whether the addition of checkpoint blockade to PTX can improve the therapeutic ...
Wan-Yu Chen, Wen-Fang Cheng, Wei-Zen Sun, Yen-Ling Lai, Yu-Li Chen, Han-Wei Lin, Chung-Liang Chien, Jung Chen   +7 more
doaj   +1 more source

PD-L1 is expressed on human activated naive effector CD4+ T cells. Regulation by dendritic cells and regulatory CD4+ T cells.

PLoS ONE, 2021
The T cell expression of various co-signalling receptors from the CD28 immunoglobulin superfamily (Inducible T cell co-stimulator (ICOS), Programmed cell death 1(PD-1), cytotoxic T lymphocyte associated protein 4 (CTLA-4), B and T lymphocyte attenuator ...
Fabienne Mazerolles, Frédéric Rieux-Laucat   +1 more
doaj   +2 more sources