Results 31 to 40 of about 5,084 (185)

Roles of BTLA in Immunity and Immune Disorders

Frontiers in Immunology, 2021
B and T lymphocyte attenuator (BTLA) is one of the most important cosignaling molecules. It belongs to the CD28 superfamily and is similar to programmed cell death-1 (PD-1) and cytotoxic T lymphocyte associated antigen-4 (CTLA-4) in terms of its ...
Zhaochen Ning, Zhaochen Ning, Keyan Liu, Huabao Xiong, Huabao Xiong   +4 more
doaj   +1 more source

B and T Lymphocyte Attenuator Is Highly Expressed on CMV-Specific T Cells during Infection and Regulates Their Function

Journal of Immunology, 2010
B and T lymphocyte attenuator (BTLA), like its relative programmed cell death-1 (PD-1), is a receptor that negatively regulates murine T cell activation. However, its expression and function on human T cells is currently unknown.
Nacer-Eddine Serriari, F. Gondois-Rey, Yves Guillaume, E. Remmerswaal, S. Pastor, N. Messal, A. Truneh, I. Hirsch, R. van Lier, D. Olive   +9 more
semanticscholar   +2 more sources

Cardiovascular Research / B- and T-lymphocyte attenuator stimulation protects against atherosclerosis by regulating follicular B cells [PDF]

, 2020
Aims The immune system is strongly involved in atherosclerosis and immune regulation generally leads to attenuated atherosclerosis. B- and T-lymphocyte attenuator (BTLA) is a novel co-receptor that negatively regulates the activation of B and T cells ...
Kuiper, Johan, Schaftenaar, Frank, Kröner, Mara, Binder, Christoph, van Puijvelde, Gijs H. M., Foks, Amanda, Douna, Hidde, Amersfoort, Jacob, Slütter, Bram, Kiss, Máté   +9 more
core   +2 more sources

Tumor Cell-Intrinsic BTLA Receptor Inhibits the Proliferation of Tumor Cells via ERK1/2

Cells, 2022
B and T lymphocyte attenuator (BTLA) is an immune checkpoint molecule that mediates the escape of tumor cells from immunosurveillance. Consequently, BTLA and its ligand herpesvirus entry mediator (HVEM) are potentially immunotherapeutic targets. However,
Tian-You Cheng, Ya-Juan Liu, Hong Yan, Yi-Bo Xi, Li-Qiang Duan, Yang Wang, Tian-Tian Zhang, Yin-Min Gu, Xiao-Dong Wang, Chang-Xin Wu, Shan Gao   +10 more
doaj   +1 more source

B and T Lymphocyte Attenuator Mediates Inhibition of Tumor-Reactive CD8+ T Cells in Patients After Allogeneic Stem Cell Transplantation [PDF]

Journal of Immunology, 2012
Allogeneic stem cell transplantation (allo-SCT) can cure hematological malignancies by inducing alloreactive T cell responses targeting minor histocompatibility antigens (MiHA) expressed on malignant cells.
W. Hobo, W. Norde, N. Schaap, H. Fredrix, F. Maas, Karen Schellens, J. F. Frederik Falkenburg, A. Korman, D. Olive, R. van der Voort, H. Dolstra   +10 more
semanticscholar   +2 more sources

Design of short peptides to block BTLA/HVEM interactions for promoting anticancer T-cell responses. [PDF]

PLoS ONE, 2017
Antibody based immune-checkpoint blockade therapy is a major breakthrough in oncology, leading to clinical benefit for cancer patients. Among the growing family of inhibitory receptors, the B and T lymphocyte attenuator (BTLA), which interacts with ...
Marta Spodzieja, Sławomir Lach, Justyna Iwaszkiewicz, Valérie Cesson, Katarzyna Kalejta, Daniel Olive, Olivier Michielin, Daniel E Speiser, Vincent Zoete, Laurent Derré, Sylwia Rodziewicz-Motowidło   +10 more
doaj   +1 more source

Friend or Foe: Prognostic and Immunotherapy Roles of BTLA in Colorectal Cancer

Frontiers in Molecular Biosciences, 2020
BackgroundB and T lymphocyte attenuator (BTLA) is a co-signaling protein belonging to the CD28 immunoglobulin superfamily. However, the role of BTLA in prognosis and immunotherapy of colorectal cancer (CRC) remains unclear.MethodsWe evaluated the ...
Jingjing Song, Jingjing Song, Lihui Wu, Lihui Wu   +3 more
doaj   +1 more source

CD8 T cell memory to a viral pathogen requires trans cosignaling between HVEM and BTLA. [PDF]

PLoS ONE, 2013
Defining the molecular interactions required to program activated CD8 T cells to survive and become memory cells may allow us to understand how to augment anti-viral immunity.
Rachel Flynn, Tarun Hutchinson, Kenneth M Murphy, Carl F Ware, Michael Croft, Shahram Salek-Ardakani   +5 more
doaj   +1 more source

The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota

Frontiers in Immunology, 2022
The herpes virus entry mediator (HVEM) is an immune checkpoint molecule regulating immune response, but its role in tissue repair remains unclear. Here, we reported that HVEM deficiency aggravated hepatobiliary damage and compromised liver repair after 3,
Yanbo Kou, Xingping Zheng, Liyuan Meng, Mengnan Liu, Shihong Xu, Qiyue Jing, Shenghan Zhang, Hanying Wang, Jinzhi Han, Zhuanzhuan Liu, Yanxia Wei, Yugang Wang   +11 more
doaj   +1 more source

Development of Autoimmune Hepatitis-like Disease and Autoantibody Production to Nuclear Antigens in Mice Lacking B and T Lymphocyte Attenuator (BTLA)

Arthritis & Rheumatism, 2008
Objective B and T lymphocyte attenuator (BTLA), a coreceptor expressed on lymphocytes, has recently been described as an inhibitory coreceptor that negatively regulates lymphocyte activation.
Yoshihiro Oya, N. Watanabe, T. Owada, Mie Oki, Koichi Hirose, A. Suto, S. Kagami, H. Nakajima, T. Kishimoto, I. Iwamoto, T. Murphy, K. Murphy, Y. Saito   +12 more
semanticscholar   +1 more source