Results 11 to 20 of about 5,084 (185)

Targeting B and T Lymphocyte Attenuator Regulates Lupus Disease Development in NZB/W Mice [PDF]

ImmunoTargets and Therapy
Léa Gherardi,* Lucie Aubergeon,* Mélanie Sayah, Jean-Daniel Fauny, Hélène Dumortier, Fanny Monneaux CNRS UPR3572, Immunology, Immunopathology and Therapeutic Chemistry, Institute of Molecular and Cellular Biology, Strasbourg, 67084, France&ast ...
Gherardi L, Aubergeon L, Sayah M, Fauny JD, Dumortier H, Monneaux F   +5 more
doaj   +3 more sources

BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection [PDF]

Frontiers in Immunology, 2019
B- and T-lymphocyte attenuator (BTLA) is an immune-regulatory receptor, similar to CTLA-4 and PD-1, and is mainly expressed on B-, T-, and all mature lymphocyte cells.
Xueping Yu, Xueping Yu, Yijuan Zheng, Richeng Mao, Zhijun Su, Jiming Zhang   +5 more
doaj   +2 more sources

BTLA Expression and Function Are Impaired on SLE B Cells [PDF]

Frontiers in Immunology, 2021
B- and T-lymphocyte attenuator (BTLA/CD272) is an inhibitory checkpoint molecule expressed on T and B cells. Prior studies reported defective function of BTLA by T cells in patients with systemic lupus erythematosus (SLE), whereas nothing is known about ...
Annika Wiedemann, Annika Wiedemann, Marie Lettau, Marie Lettau, Sarah Y. Weißenberg, Sarah Y. Weißenberg, Ana-Luisa Stefanski, Ana-Luisa Stefanski, Eva-Vanessa Schrezenmeier, Eva-Vanessa Schrezenmeier, Eva-Vanessa Schrezenmeier, Hector Rincon-Arevalo, Hector Rincon-Arevalo, Hector Rincon-Arevalo, Hector Rincon-Arevalo, Karin Reiter, Karin Reiter, Tobias Alexander, Tobias Alexander, Falk Hiepe, Falk Hiepe, Andreia C. Lino, Andreia C. Lino, Thomas Dörner, Thomas Dörner   +24 more
doaj   +2 more sources

Abnormal Expression of BTLA and CTLA-4 Immune Checkpoint Molecules in Chronic Lymphocytic Leukemia Patients

Journal of Immunology Research, 2020
Chronic lymphocytic leukemia (CLL) is characterized by the peripheral accumulation of neoplastic B cells and is frequently complicated by the systemic immunosuppression associated with an impairment in B and T lymphocyte activation.
L. Karabon, A. Partyka, L. Ciszak, E. Pawlak-Adamska, A. Tomkiewicz, A. Bojarska-Junak, J. Roliński, D. Wołowiec, T. Wrobel, I. Frydecka, A. Kosmaczewska   +10 more
doaj   +2 more sources

Serum levels of soluble B and T lymphocyte attenuator predict overall survival in patients undergoing immune checkpoint inhibitor therapy for solid malignancies

International Journal of Cancer, 2021
Therapy with immune checkpoint inhibitors (ICIs) can lead to durable tumor control in patients with various advanced stage malignancies. However, this is not the case for all patients, leading to an ongoing search for biomarkers predicting response and ...
Frank Tacke, Fabian Beier, Jakob Nikolas Kather   +2 more
exaly   +2 more sources

BTLA inhibition has a dominant role in the cis-complex of BTLA and HVEM

Frontiers in Immunology, 2022
The engagement of the herpesvirus entry mediator (HVEM, TNFRSF14) by the B and T lymphocyte attenuator (BTLA) represents a unique interaction between an activating receptor of the TNFR-superfamily and an inhibitory receptor of the Ig-superfamily.
Claire Battin, Judith Leitner, Petra Waidhofer-Söllner, Katharina Grabmeier-Pfistershammer, Daniel Olive, Peter Steinberger   +5 more
doaj   +2 more sources

A Functional Polymorphism in B and T Lymphocyte Attenuator Is Associated with Susceptibility to Rheumatoid Arthritis [PDF]

Clinical and Developmental Immunology, 2011
Inhibitory coreceptors are thought to play important roles in maintaining immunological homeostasis, and a defect in the negative signals from inhibitory coreceptors may lead to the development of autoimmune diseases. We have recently identified B and T
Mie Oki, Norihiko Watanabe, Takayoshi Owada, Yoshihiro Oya, Kei Ikeda, Yasushi Saito, Ryutaro Matsumura, Yohei Seto, Itsuo Iwamoto, Hiroshi Nakajima   +9 more
doaj   +2 more sources

Admission CD4+ T cell BTLA expression and its association with infection risk and respiratory outcomes in sepsis [PDF]

Frontiers in Cellular and Infection Microbiology
ObjectiveT cell co-inhibitory molecule upregulation is linked to sepsis-induced immune suppression, but the relationship between B and T lymphocyte attenuator (BTLA) expression and ICU-acquired infection or organ function recovery in sepsis remains ...
Shuwei Ning, Ying Liu, Changmeng Cao, Ailin Song, Rongxin Sun, Ziqi Rong, Chungang Zhao   +6 more
doaj   +2 more sources

The Influence of B and T Lymphocyte Attenuator Genetic Variants on Susceptibility to Chronic Hepatitis B Virus Infection [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: B and T lymphocyte attenuator (BTLA) is an immune inhibitory receptor involved in the pathogenesis of chronic viral infections. Little is known about the effects of BTLA gene polymorphisms on chronic hepatitis B virus (HBV) infections ...
Jie Tang, Jiaqian Fei, Chunxia Gu, Weixia Liu, Minwei Li, Cheng Zhou   +5 more
doaj   +3 more sources

The BTLA/HVEM axis as a key regulator for stratified functional cure in chronic hepatitis B [PDF]

Frontiers in Immunology
BackgroundFunctional cure rates in chronic hepatitis B (CHB) remain below 10% after long-term nucleos(t)ide analogue (NA) therapy, and PD-1/PD-L1 blockade achieves HBsAg clearance in approximately 30% of selected patients with low baseline HBsAg (≤100 IU/
Yuzhen Zhang, Shuqi Yang, Yanyan Lin, Yanyan Qiu, Xueping Yu, Xueping Yu   +5 more
doaj   +2 more sources