Results 41 to 50 of about 5,084 (185)

BTLA Expression in CLL: Epigenetic Regulation and Impact on CLL B Cell Proliferation and Ability to IL-4 Production

Cells, 2021
In our previous study, while chronic lymphocytic leukemia (CLL) cases showed higher levels of B and T lymphocyte attenuator (BTLA) mRNA compared to controls, lower BTLA protein expression was observed in cases compared to controls.
Lidia Karabon, Anna Andrzejczak, Lidia Ciszak, Anna Tomkiewicz, Aleksandra Szteblich, Agnieszka Bojarska-Junak, Jacek Roliński, Dariusz Wołowiec, Tomasz Wróbel, Agata Kosmaczewska   +9 more
doaj   +1 more source

The BTLA and PD‐1 signaling pathways independently regulate the proliferation and cytotoxicity of human peripheral blood γδ T cells

Immunity, Inflammation and Disease, 2021
Background B‐ and T‐lymphocyte attenuator (BTLA) and programmed cell death‐1 (PD‐1) inhibit γδ T cell homeostasis and activation. This study aimed to determine whether BTLA and PD‐1 signaling pathways were convergent or independent in human peripheral ...
Hyun J. Hwang, Jae J. Lee, Sung H. Kang, Jin K. Suh, Eun S. Choi, Seongsoo Jang, Sang‐Hyun Hwang, Kyung‐Nam Koh, Ho J. Im, Nayoung Kim   +9 more
doaj   +1 more source

High BTLA Expression Likely Contributes to Contraction of the Regulatory T Cell Subset in Lupus Disease

Frontiers in Immunology, 2021
B and T lymphocyte attenuator (BTLA) is a co-inhibitory receptor that is expressed by lymphoid cells and regulates the immune response. Consistent with an inhibitory role for BTLA, the disease is exacerbated in BTLA-deficient lupus mice.
Lucie Aubergeon, Matthieu Sawaf, Renaud Felten, Renaud Felten, Jacques-Eric Gottenberg, Jacques-Eric Gottenberg, Hélène Dumortier, Fanny Monneaux   +7 more
doaj   +1 more source

Stimulation of Immune Checkpoint Molecule B and T-Lymphocyte Attenuator Alleviates Experimental Crescentic Glomerulonephritis

Journal of the American Society of Nephrology, 2023
Significance Statement Treatment of acute, crescentic glomerulonephritis (GN) consists of unspecific and potentially toxic immunosuppression. T cells are central in the pathogenesis of GN, and various checkpoint molecules control their activation.
P. Diefenhardt, M. Braumann, Thomas Schömig, Bastian Trinsch, Claudio Sierra Gonzalez, Janine Becker-Gotot, L. A. Völker, Lioba Ester, Amrei M. Mandel, D. Hawiger, Ali T. Abdallah, B. Schermer, Heike Goebel, P. Brinkkoetter, C. Kurts, T. Benzing, Sebastian Brähler   +16 more
semanticscholar   +1 more source

B and T lymphocyte Attenuator, BTLA, Regulates T cell Survival in the Lung1

Journal of Immunology, 2008
The initiation, intensity, and duration of T cell-directed inflammatory responses are dependent upon the coordination of both activating and inhibitory signals mediated by specific receptors on the T lymphocyte.
Christine M. Deppong, Jessica M. Degnan, T. Murphy, K. Murphy, Jonathan M. Green   +4 more
semanticscholar   +1 more source

B- and T-lymphocyte attenuator could be a new player in accelerated atherosclerosis associated to chronic kidney disease.

Clinical science, 2023
BACKGROUND In chronic kidney disease (CKD), cardiovascular morbi-mortality is higher than in general population. Atherosclerotic cardiovascular disease is accelerated in CKD, but specific CKD-related risk factors for atherosclerosis are unknown.  Methods:
Nuria Doladé, S. Rayego‐Mateos, A. García-Carrasco, M. Guerin, J. Martín-Ventura, M. Ruíz-Ortega, P. Tharaux, J. Valdivielso   +7 more
semanticscholar   +1 more source

Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction [PDF]

, 2009
T cell activation and tolerance are delicately regulated by costimulatory molecules. Although B and T lymphocyte attenuator (BTLA) has been shown as a negative regulator for T cell activation, its role in peripheral T cell tolerance induction in vivo has
Liu, X, Lu, S, Martin-Orozco, N, Kollias, G, Dong, C, Nurieva, R I, Chung, Y, Graf, D, Tian, Q, Alexiou, M, Ma, L   +10 more
core   +1 more source

Therapeutic Potential of B and T Lymphocyte Attenuator Expressed on CD8+ T Cells for Contact Hypersensitivity [PDF]

, 2013
In the past decade, mechanisms underlying allergic contact dermatitis have been intensively investigated by using contact hypersensitivity (CHS) models in mice.
Murphy, Theresa L., Murphy, Kenneth M., Nakajima, Hiroshi, Nakagomi, Daiki, Suto, Akira, Hosokawa, Junichi, Kobayashi, Yoshihisa, Takatori, Hiroaki, Watanabe, Norihiko, Suzuki, Kotaro, Matsue, Hiroyuki, Shimada, Shinji   +11 more
core   +1 more source

Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions. [PDF]

MedComm (2020)
Immune exhaustion is a well‐established hallmark of both cancer and chronic infection. This review proposes a novel “infection–exhaustion–tumor axis” framework, wherein chronic pathogens (e.g., oncogenic viruses) evade immune surveillance by hijacking inflammatory signaling to drive immune cell exhaustion, thereby creating immunosuppressive niches ...
Song Y, Mo Y, Chen S, Chen Y, Zhang C, Deng S, Liao J, He Y, Wang W, Zheng W, Zeng T.   +10 more
europepmc   +2 more sources

Selective Blockade of Herpesvirus Entry Mediator–B and T Lymphocyte Attenuator Pathway Ameliorates Acute Graft-versus-Host Reaction [PDF]

, 2012
[EN] The cosignaling network mediated by the herpesvirus entry mediator (HVEM; TNFRSF14) functions as a dual directional system that involves proinflammatory ligand, lymphotoxin that exhibits inducible expression and competes with HSV glycoprotein D for ...
Río González, María Luisa del, Buhler, Leo, Norris, Paula, Shintani, Yasushi, Jones, N. D., Rodríguez Barbosa, José Ignacio, Ware, Carl F.   +6 more
core   +2 more sources