Results 21 to 30 of about 5,084 (185)

Monoclonal antibodies to B and T lymphocyte attenuator (BTLA) have no effect on in vitro B cell proliferation and act to inhibit in vitro T cell proliferation when presented in a cis, but not trans, format relative to the activating stimulus

Clinical and Experimental Immunology, 2010
Summary B and T lymphocyte attenuator (BTLA) is an immunoglobulin superfamily member surface protein expressed on B and T cells. Its ligand, herpesvirus entry mediator (HVEM), is believed to act as a monomeric agonist that signals via the CRD1 of HVEM to inhibit lymphocyte activation: HVEM is also the receptor for lymphotoxin-α and LIGHT,
M, Zhang, K, Howard, A, Winters, S, Steavenson, S, Anderson, S, Smelt, G, Doellgast, C, Sheelo, J, Stevens, H, Kim, A, Hamburger, A, Sein, D J, Caughey, F, Lee, H, Hsu, G, Siu, F R, Byrne   +16 more
openaire   +4 more sources

Analysis of Immune Checkpoints on Peripheral Blood Mononuclear Cells Can Predict Clinical Outcome and Reveal Potential of HVEM-BTLA Axis in Epithelial Ovarian Cancers [PDF]

Pharmaceuticals
Background/Objectives: Immune checkpoint inhibitors (ICIs) do not provide promising benefits to patients with advanced epithelial ovarian cancer (EOC).
Yen-Ling Lai, Han-Wei Lin, Yu-Wen Huang, Jung Chen, Ming-Chien Tai, Chia-Ying Wu, Tyan-Shin Yang, Valentina Oblin, Kristin Shea, Yu-Li Chen   +9 more
doaj   +2 more sources

Soluble B and T Lymphocyte Attenuator Correlates to Disease Severity in Sepsis and High Levels Are Associated with an Increased Risk of Mortality

PLoS ONE, 2017
Introduction and aims B- and T-lymphocyte Attenuator (BTLA), Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and Programmed Death 1 (PD-1) are co-inhibitory receptors that regulate T cell activation.
Anna Lange, Jonas Sundén-Cullberg, Anders Magnuson   +2 more
exaly   +2 more sources

BTLA contributes to acute-on-chronic liver failure infection and mortality through CD4+ T-cell exhaustion

Nature Communications
B- and T-lymphocyte attenuator (BTLA) levels are increased in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). This condition is characterized by susceptibility to infection and T-cell immune exhaustion. However, whether
Xueping Yu, Feifei Yang, Zhongliang Shen, Yao Zhang, Jian Sun, Chao Qiu, Yijuan Zheng, Weidong Zhao, Songhua Yuan, Dawu Zeng, Shenyan Zhang, Jianfei Long, Mengqi Zhu, Xueyun Zhang, Jingwen Wu, Zhenxuan Ma, Haoxiang Zhu, Milong Su, Jianqing Xu, Bin Li, Richeng Mao, Zhijun Su, Jiming Zhang   +22 more
doaj   +2 more sources

Inhibitory immune checkpoints in preeclampsia: current landscape, mechanisms, and clinical perspectives [PDF]

Frontiers in Immunology
Preeclampsia (PE) is a pregnancy-specific disorder whose pathogenesis remains incompletely elucidated. The prevailing theory suggests that compromised maternal-fetal immune tolerance is a key contributor.
Mi Liu, Guikai Duan, Xiaomin Lai, Bingying Lin, Xiang Li, Jie Yang, Shu Cao, Hao Chen, Tong Wang, Bingyan Chen, Zhihua He, Qinglin Ma, Chun Duan, Yan Zhu, Yuanbin Lu, Yuanbin Lu, Yuchi Gao, Yuchi Gao   +17 more
doaj   +2 more sources

cTfh Cell Activation and Changes in BTLA and LAG-3 Expression Differentially Associate With Poor Pregnancy Outcome in Plasmodium falciparum Placental Malaria [PDF]

Journal of Immunology Research
Continuous exposure to antigens drives the activation of circulating T follicular helper (cTfh) cells, promoting high-affinity antibody production. However, sustained stimulation may impair their function through the upregulation of immunoregulatory ...
Bernard Marie Zambo Bitye, Chris Marco Mbianda Nana, Bodin Darcisse Kwanou Tchakounte, Balotin Fogang, Berenice Kenfack Tekougang Zangue, Reine Seumko’o Medouen Ndeumou, Lawrence Ayong, Rosette Megnekou   +7 more
doaj   +2 more sources

Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness

Molecular Medicine, 2018
Background Critically ill patients with sepsis and acute respiratory distress syndrome have severely altered physiology and immune system modifications. RNA splicing is a basic molecular mechanism influenced by physiologic alterations.
Sean F. Monaghan, Debasree Banerjee, Chun-Shiang Chung, Joanne Lomas-Neira, Kamil J. Cygan, Christy L. Rhine, William G. Fairbrother, Daithi S. Heffernan, Mitchell M. Levy, William G. Cioffi, Alfred Ayala   +10 more
doaj   +2 more sources

Single‐cell RNA sequencing of peripheral blood mononuclear cells from bronchopulmonary dysplasia [PDF]

Clinical and Translational Medicine
Background Bronchopulmonary dysplasia (BPD) is a severe respiratory disease that primarily affects premature infants, characterized by persistent inflammation and abnormal immune activation.
Yufeng Liu, Chun Yan, Yushan Li, Ruoxing Zhou, Xiaoyu Lin, Qiong Meng, Sitao Li, Limei Zhong, Yanfang Tan, Wangkai Liu   +9 more
doaj   +2 more sources

1224 Utilizing drug intelligence science (DIS®) for tumor type selection and molecular characterization of HFB200603, a best-in-class B and T lymphocyte attenuator (BTLA) monoclonal antagonist

Regular and Young Investigator Award Abstracts
Germain Margall, Hombline Poullain, Gabrielle Wong, Juying Li, Eladio Marquez, Spencer Huggett, Hani Alostaz, Joshua Whitener, Shaozhen Xie, Xi Lin, Olja Rapaic, William Hedrich, Jinping Gan, Jack Russella-Pollard, Liang Schweizer, Robert HI Andtbacka   +15 more
openaire   +2 more sources

A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator

Proceedings of the National Academy of Sciences of the United States of America, 2005
Wenjun Ouyang, Kelly M Loyet, Lino Gonzalez   +2 more
exaly   +2 more sources