Results 281 to 290 of about 31,156,887 (403)

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

Nature, 2010
R. Davis, V. Ngo, G. Lenz, P. Tolar, R. Young, Paul B. Romesser, H. Kohlhammer, L. Lamy, Hong Zhao, Yandan Yang, Weihong Xu, A. Shaffer, George W. Wright, Wenming Xiao, J. Powell, Jian-Kang Jiang, Craig J. Thomas, A. Rosenwald, G. Ott, H. Müller-hermelink, R. Gascoyne, J. Connors, N. Johnson, L. Rimsza, E. Campo, E. Jaffe, W. Wilson, J. Delabie, E. Smeland, R. Fisher, R. Braziel, R. Tubbs, J. Cook, D. Weisenburger, W. C. Chan, S. Pierce, L. Staudt   +36 more
semanticscholar   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Letter to editor: Complementary perspectives on B cell regulatory phenotypes in cancer. [PDF]

Front Immunol
Patel AJ, Middleton GW.
europepmc   +1 more source

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells.

Blood, 2012
J. Kochenderfer, M. Dudley, S. Feldman, W. Wilson, D. Spaner, I. Maric, M. Stetler-Stevenson, G. Phan, M. Hughes, R. Sherry, J. Yang, U. Kammula, Laura Devillier, R. Carpenter, Debbie-Ann N. Nathan, R. Morgan, C. Laurencot, S. Rosenberg   +17 more
semanticscholar   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Primary Breast Lymphoma: A Rare Presentation of Diffuse Large B-Cell Lymphoma, Germinal Center B-Cell Subtype (DLBCL-GCB). [PDF]

Cureus
Chrysikos D, Livieratou E, Giannouli S, Kontogeorgou A, Shihada A, Nonni A, Korkolopoulou P, Troupis T.   +7 more
europepmc   +1 more source

Single-Cell Trajectory Detection Uncovers Progression and Regulatory Coordination in Human B Cell Development

Cell, 2014
S. Bendall, K. Davis, E. Amir, Michelle D. Tadmor, Erin F. Simonds, Tiffany J. Chen, Daniel K. Shenfeld, G. Nolan, D. Pe’er   +8 more
semanticscholar   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source