Results 101 to 110 of about 8,044,473 (306)

Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA [PDF]

, 2009
U1-snRNA is an integral part of the U1 ribonucleoprotein pivotal for pre-mRNA splicing. Toll-like receptor (TLR) signaling has recently been associated with immunoregulatory capacities of U1-snRNA.
C. D. Sadik, M. Bachmann, J. Pfeilschifter, H. Muhl, Busch, Will, Hoet, Lovgren, Hoffman, Casciola-Rosen, Biggiogera, Malmegrim, Dieker, Rosen, Hof, Vandivier, Bowie, Gantier, Schr  der, Matsumoto, Honda, Yoneyama, Schleimer, M  ller, Sexton, Monks, Dow, Colin, O'neill, Schreiber, Schafer, Taniguchi, Colonna, Tamura, Hemmi, M  hl, Reddy, Sioud, Degen, Sturchier, Gowen, Nagai, Pirher, Platanias, Grumbach, Yu, Chung, Krysko, King, Akbar, Vervoordeldonk, Nikolaus, Wirtz, Hemmer, Katakura, Sel, Fadok, Voll, Moller, O'Garra   +59 more
core   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

A B cell-derived gene expression signature associates with an immunologically active tumor microenvironment and response to immune checkpoint blockade therapy

OncoImmunology, 2019
Immune checkpoint inhibitors have shown great potential in treating solid tumors, inducing durable remission and prolonged survival time in responders.
Frederick S. Varn, Yue Wang, Chao Cheng
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Aggressive B-Cell Lymphomas

Advances in Hematology, 2012
Aggressive B-cell lymphomas (ABLs) are a group of B-cell malignancies, that is, a relatively common form of cancer across the world. This issue on aggressive B-cell lymphomas compiles 12 exciting manuscripts, most of which are very meticulously performed reviews of the available current literature.
Naresh KN, Magrath I, Raphael M, LEONCINI, LORENZO   +3 more
openaire   +4 more sources

B Cell Activation in Insulin Resistance and Obesity [PDF]

, 2011
Our group has demonstrated that inflammatory diseases such as type 2 diabetes (DM), inflammatory bowel disease (IBD), and periodontal disease (PD) are associated with altered B cell function that may contribute to disease pathogenesis. B cells were found
Apovian, Caroline, Ganley-Leal, Lisa, Gokce, Noyan, Liang, YanMei, McDonnell, Marie, Mehta, Ankeeta, Zhang, Jeanette   +6 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Monoclonal B-cell lymphocytosis

Revista Brasileira de Hematologia e Hemoterapia, 2015
color antibody-fluorochrome combinations or four to eightcolor antibody-fluorochrome combinations). Furthermore, itis well established that the prevalence increases with age. In arecent study in Spain, 608 healthy individuals were evaluatedwith an eight-color antibody panel. The overall prevalence ofMBL was 14%; it was around 5% in under 60-year-old indi-
Irene Biasoli, Nelson Spector
openaire   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source