Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Transport of B-Vitamins in Microorganisms. III. Chromatographic Studies on the Radioactivity Extracted from Non-proliferating Cells of Lactobacillus fermenti after Exposure to Labelled Thiamine. [PDF]
, 1966 Halina Y. Neujahr +7 more
openalex +1 more source
FEBS Letters, EarlyView.This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter +8 more
wiley +1 more source
Possible Role of CD11a in Primary Immune Thrombocytopenia Patients on Immunosuppressive Therapy
Journal of Blood Medicine, 2021 Muhamad R Abdel Hameed,1,2 Howiada A Nafady,1,2 Mona Ibrahim Mostafa,3 Douaa Sayed,4 Ahmad A Obiedallah5 1Hematology Unit, Department of Internal Medicine, Assiut University Hospitals, Assiut University, Assiut, Egypt; 2Bone Marrow Transplantation Unit ...
Abdel Hameed MR +4 more
doaj
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Transport of B-Vitamins in Microorganisms. II. Factors Affecting the Uptake of Labelled Thiamine by Nonproliferating Cells of Lactobacillus fermenti. [PDF]
, 1966 Halina Y. Neujahr +7 more
openalex +1 more source
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
Transport of B-Vitamins in Microorganisms. VI. The Non-specificity of the Effect of Exogeneous ATP on the Uptake of Labelled Thiamine by Non-proliferating Thiamine Deficient Cells of L. fermenti. A Reappraisal. [PDF]
, 1966 Halina Y. Neujahr +7 more
openalex +1 more source
Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice
FEBS Letters, EarlyView.In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász +6 more
wiley +1 more source