Results 211 to 220 of about 21,803,006 (294)

The Role of B Cells in Tumorigenesis and Immunotherapy. [PDF]

Immune Netw
Yin G, Qi L, Kang N, Li T, Li C, Liu YE, Ye J, Liu W.   +7 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

B cells and iBALT in TB immunity & pathogenesis. [PDF]

Front Immunol
Dutt TS, Krause R, Hertz D, Henao-Tamayo M, Leslie A, Schneider B.   +5 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Beyond B cells: T and Innate Immune Mechanisms of Autoimmunity in Common Variable Immunodeficiency. [PDF]

Clin Rev Allergy Immunol
Kowalczyk P, Zima K, Sowa-Rogozińska N, Majewska-Szczepanik M, Ziętkiewicz M.   +4 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Tumor-infiltrating B cells inhibit nasopharyngeal carcinoma metastasis. [PDF]

Cell Death Dis
Cai J, Tan X, Liu X, Feng J, Deng X, Zhao L.   +5 more
europepmc   +1 more source