Results 201 to 210 of about 21,803,006 (294)

Correction: Early-life homeostatic differentiation of thymus-resident B cells into memory B cells. [PDF]

Front Immunol
Castañeda J, Poblete L, Rosemblatt MV, Sauma D, Rosemblatt M, Bono MR, Nuñez S.   +6 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

ER proteostasis failure in HYOU1 deficiency alters B cells, neutrophils, and interferon signalling. [PDF]

J Hum Immun
Idani A, Bibi-Triki S, Stemmelen T, Radosavljevic M, Grenot P, Hirschler A, Bernard A, Rosenzwajg M, Yang J, Eischen A, Naegely L, Macquin C, Pichot A, Spinnhirny P, Hanauer A, Alipour-Olayei N, Cherrier T, Kolmer A, Paul N, Olson RJ, Morava E, Miao Z, Carapito C, Rostami P, Parvaneh N, Shahrooei M, Molitor A, Carapito R, Bahram S.   +28 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Tonsillar Tfh cells contribute to the pathogenesis of IgA nephropathy in collaboration with memory B cells. [PDF]

Front Immunol
Sugaya T, Ikegami I, Kamekura R, Yorozu A, Sakamoto H, Tatekoshi A, Tanemoto M, Ohyu T, Shirato S, Takano KI, Ichimiya S.   +10 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Age-associated B cells predict coronary events in humans and aggravate murine atherosclerosis. [PDF]

Cardiovasc Res
de Mol J, Katra P, Smit V, Witteveen A, Tomas L, Andersson L, Engels SWM, Andersson S, Bernabé Kleijn MNA, Schiopu A, Bengtsson E, Bot I, Engelbertsen D, Kuiper J, Björkbacka H, Foks AC.   +15 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source