Results 181 to 190 of about 4,576,202 (266)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

CLL cell-derived soluble factors do not influence the functionality of normal B cells. [PDF]

Front Immunol
Elbert MM, Budeus B, Dampmann M, Kahlert N, Kibler A, Knittel G, Reinhardt HC, Küppers R.   +7 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mechanisms of IgE-mediated food allergy and the role of allergen-specific B cells. [PDF]

FEBS Lett
López JF, Ardicli ÖY, Akdis M.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Impaired suppressive effect of FoxP3 regulatory T cells on B cells in multiple sclerosis. [PDF]

J Neuroinflammation
Greeck VB, Würthwein C, Mimura K, Mattes K, Kutza M, Schirmer L, Fairless R, Williams SK, Jarius S, Haas J, Ruprecht K, Wildemann B.   +11 more
europepmc   +1 more source

B Cell and Autoimmunity.

Japanese Journal of Clinical Immunology, 1998
openaire   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Response of B Cells Specific for Polyomavirus-Derived Oncoprotein Is Predictive of Merkel Cell Carcinoma Tumor Control. [PDF]

Cancer Immunol Res
Rodriguez Chevez HJ, Remington AJ, Gray MD, Alam R, Gilmour MW, Morningstar C, Alencar GF, Pulliam T, McClure EM, Singh N, Urselli F, Ouellette S, Poljakov K, Smythe KS, Kulikauskas RM, Robinson KL, Moshiri AS, Yeung CCS, Lin M, Shimp KR, Schwartz A, Macy AM, Tooley MR, Baker ML, Carter JJ, Hopwo K, Singhi N, Bakhtiari J, Ruterbusch M, Shasha C, Iuliano M, Mullen LJ, DeBuysscher BL, Veatch JR, Koelle DM, Galloway DA, Nghiem P, Taylor JJ.   +37 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source