Results 71 to 80 of about 26,623 (217)

Interaction and cross-talk between non-coding RNAs. [PDF]

, 2017
Non-coding RNA (ncRNA) has been shown to regulate diverse cellular processes and functions through controlling gene expression. Long non-coding RNAs (lncRNAs) act as a competing endogenous RNAs (ceRNAs) where microRNAs (miRNAs) and lncRNAs regulate each ...
Dahiya, Rajvir, Imai-Sumida, Mitsuho, Tanaka, Yuichiro, Yamamura, Soichiro   +3 more
core   +2 more sources

BACE1^-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization

Molecular Neurodegeneration, 2010
Background BACE1 is a key enzyme in the generation of the Aβ peptide that plays a central role in the pathogenesis of Alzheimer's disease. While BACE1 is an attractive therapeutic target, its normal physiological function remains largely unknown ...
Hitt Brian D, Jaramillo Thomas C, Chetkovich Dane M, Vassar Robert   +3 more
doaj   +1 more source

HIV-1 Tat-mediated astrocytic amyloidosis involves the HIF-1α/lncRNA BACE1-AS axis.

PLoS Biology, 2020
Increased life expectancy of patients diagnosed with HIV in the current era of antiretroviral therapy is unfortunately accompanied with the prevalence of HIV-associated neurocognitive disorders (HANDs) and risk of comorbidities such as Alzheimer-like ...
Susmita Sil, Guoku Hu, Ke Liao, Fang Niu, Shannon Callen, Palsamy Periyasamy, Howard S Fox, Shilpa Buch   +7 more
doaj   +1 more source

Intracellular protein GBF1 displays significant associations with amyloid pathology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Despite the identification of familial Alzheimer's disease (FAD) genes and neuropathological alterations, AD displays complex genetic heterogeneity and molecular pathogenesis that warrant further investigation. GBF1 (Golgi brefeldin A resistant guanine nucleotide exchange factor 1) regulates protein trafficking, and genetic ...
Sean J. Miller, Dmitry Prokopenko, Ping Bai, Prasenjit Mondal, Abigael Scott, Wei Zhang, Ashley Gomm, Siyi Zhang, Daniel D. Child, Nolan Shen, Joseph Ward, Scott Schulte, Dan Lei, Brian P. Hafler, Changning Wang, Rudolph E. Tanzi, Can Zhang   +16 more
wiley   +1 more source

DNA Aptamers Targeting BACE1 Reduce Amyloid Levels and Rescue Neuronal Deficiency in Cultured Cells

Molecular Therapy: Nucleic Acids, 2019
β-amyloid (Aβ) plays an essential role in the pathogenesis of Alzheimer’s disease (AD). Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is indispensable for Aβ production, and knockout of BACE1 has no overt phenotypes in mouse.
Jun Xiang, Wen Zhang, Xiao-Fang Cai, Min Cai, Zhong-Hai Yu, Feng Yang, Wen Zhu, Xiang-Ting Li, Ting Wu, Jing-Si Zhang, Ding-Fang Cai   +10 more
doaj   +1 more source

Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design [PDF]

, 2013
β-Secretase (BACE1), the enzyme responsible for the first and rate-limiting step in the production of amyloid-β peptides, is an attractive target for the treatment of Alzheimer’s disease.
A. Peter Johnson, Aoyama T., Baret P., Baxter E. W., Bedford R. B., Besong G. E., Callaway E., Cesar J., Cole D. C., Colin W. G. Fishwick, Coutts R. T., Davies M., Eder J., Eva Casas-Arce, Ghosh A. K., Ghosh A. K., Gillet V. J., Goodyer C. L. M., Guengerich F. P., Hardy J. A., Hong L., Hooper N. M., Huang D. Z., Huang D. Z., Huang W. H., Hussain I., James Chadwick, Ju Y. H., Katherine A. B. Kellett, Law J. M. S., Lin X. L., Mancini F., Mok N. Y., N. Yi Mok, Nigel M. Hooper, Parvathy S., Robichaud J., Selkoe D. J., Serafin B., Sinha S., Sun X. L., Vassar R., Woon E. C. Y., Xu W. J.   +43 more
core   +1 more source

Evaluating the peripheral nervous system pathology of Alzheimer's disease utilizing a functional human NMJ microphysiological system

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Alzheimer's Disease (AD) is a central nervous system (CNS) neurodegenerative disease leading to dementia, but can also show symptoms of motor deficits. It is not clear whether the peripheral motor deficits in AD are derived from upstream centers or intrinsic to the neuromuscular circuit.
Akhmetzada Kargazhanov, Romy Aiken, Kenneth Hawkins, Rafael Lopez, Ahmad Nawaz, Gaurav Srivastava, Chase Miller, Will Bogen, Christopher Long, David Morgan, Xiufang Guo, James Hickman   +11 more
wiley   +1 more source

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

EMBO Molecular Medicine, 2015
The β‐site amyloid precursor protein cleaving enzyme‐1 (BACE1), an essential protease for the generation of amyloid‐β (Aβ) peptide, is a major drug target for Alzheimer's disease (AD).
Yasuhiko Kizuka, Shinobu Kitazume, Reiko Fujinawa, Takashi Saito, Nobuhisa Iwata, Takaomi C Saido, Miyako Nakano, Yoshiki Yamaguchi, Yasuhiro Hashimoto, Matthias Staufenbiel, Hiroyuki Hatsuta, Shigeo Murayama, Hiroshi Manya, Tamao Endo, Naoyuki Taniguchi   +14 more
doaj   +1 more source

Non-proteolytic effect of β-site APP-cleaving enzyme 1 (BACE1) on sodium channel function

Neurobiology of Disease, 2009
The β-site APP-cleaving enzyme 1 (BACE1) is widely known for its pivotal role in the amyloidogenic pathway leading to Alzheimer's disease. Here, we elaborate on the recent finding that auxiliary subunits of voltage-gated sodium channels (β2 and β4) are ...
Tobias Huth, Karoline Schmidt-Neuenfeldt, Andrea Rittger, Paul Saftig, Karina Reiss, Christian Alzheimer   +5 more
doaj   +1 more source

β-Secretase1 biological markers for Alzheimer’s disease: state-of-art of validation and qualification

Alzheimer’s Research & Therapy, 2020
β-Secretase1 (BACE1) protein concentrations and rates of enzyme activity, analyzed in human bodily fluids, are promising candidate biological markers for guidance in clinical trials investigating BACE1 inhibitors to halt or delay the dysregulation of the
Harald Hampel, Simone Lista, Eugeen Vanmechelen, Henrik Zetterberg, Filippo Sean Giorgi, Alessandro Galgani, Kaj Blennow, Filippo Caraci, Brati Das, Riqiang Yan, Andrea Vergallo, for the Alzheimer’s Precision Medicine Initiative (APMI)   +11 more
doaj   +1 more source