Results 91 to 100 of about 26,623 (217)

S-adenosylmethionine and superoxide dismutase 1 synergistically counteract Alzheimer's disease features progression in tgCRND8 mice [PDF]

, 2017
Recent evidence emphasizes the role of dysregulated one-carbon metabolism in Alzheimer's Disease (AD). Exploiting a nutritional B-vitamin deficiency paradigm, we have previously shown that PSEN1 and BACE1 activity is modulated by one-carbon metabolism ...
Cavallaro, Rosaria A, Fiorenza, Maria Teresa, Fuso, Andrea, Nicolia, Vincenzina, Scarpa, Sigfrido   +4 more
core   +2 more sources

Indirubin and Retinoic Acid Show Binding Affinity to Monocyte Biomarker CSF3R in Parkinson's Disease

Journal of Clinical Laboratory Analysis, Volume 40, Issue 8, April 2026.
Through single‐cell RNA‐sequencing and high‐dimensional weighted gene co‐expression network analysis, two monocyte‐related biomarkers (CSF3R, IFITM3) were identified in the peripheral blood of Parkinson's disease. Molecular docking revealed two targeted drugs (Indirubin and Retinoic acid).
Zhiwei Bao, Shao Zhi, Mao Jie
wiley   +1 more source

Structural and functional insights into the anti-BACE1 Fab fragment that recognizes the BACE1 exosite

Journal of Biomolecular Structure and Dynamics, 2013
A molecular modeling study giving structural, functional, and mutagenesis insights into the anti-BACE1 Fab fragment that recognizes the BACE1 exosite is reported. Our results allow extending experimental data resulting from X-ray diffraction experiments in order to examine unknown aspects for the Fab-BACE1 recognition and its binding mode.
Gutierrez, Lucas Joel, Andujar, Sebastian Antonio, Enriz, Ricardo Daniel, Baldoni, Hector Armando   +3 more
openaire   +3 more sources

BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer’s Disease Pathology

Molecules, 2017
Alzheimer’s disease (AD) is a fatal progressive neurodegenerative disorder characterized by increasing loss in memory, cognition, and function of daily living.
Gerald Koelsch
doaj   +1 more source

Ectodomain shedding of the amyloid precursor protein: Cellular control mechanisms and novel modifiers [PDF]

, 2006
Proteolytic cleavage in the ectodomain of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer's disease amyloid-beta (A beta) pepticle and occurs through two different protease activities termed alpha- and beta-
Lichtenthaler, Stefan F.
core   +1 more source

Toxic mechanisms of amyloid oligomers and therapeutic strategies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

Biological evaluation and interaction mechanism of beta-site APP cleaving enzyme 1 inhibitory pentapeptide from egg albumin

Food Science and Human Wellness, 2020
Inhibition of beta-site APP cleaving enzyme1 (BACE1) is one of the most promising therapeutic approaches for Alzheimer’s disease. To find natural products for the treatment of Alzheimer's disease, absorption, distribution, metabolism, excretion and ...
Zhipeng Yu, Sijia Wu, Wenzhu Zhao, Long Ding, David Shiuan, Fuping Zheng, Jianrong Li, Jingbo Liu   +7 more
doaj   +1 more source

BACE1 modulates filopodia-like protrusions induced by sodium channel β4 subunit [PDF]

, 2007
journal ...
Kaneko Kumi, Miyazaki Haruko, Nukina Nobuyuki, Oyama Fumitaka, Sakurai Takashi, TAMAOKA Akira, Wong Hon-Kit   +6 more
core   +1 more source

Early Animal Origin of BACE1 APP/Aβ Proteolytic Function

Biology
Alzheimer’s disease is characterized, in part, by the accumulation of β-amyloid (Aβ) in the brain. Aβ is produced via the proteolysis of APP by BACE1 and γ-secretase.
James A. Langeland, Lillian Baumann, Eva M. DeYoung, Raphaela Angelina Varella, Nkatha Mwenda, Alejandro Aguirre, D. Blaine Moore   +6 more
doaj   +1 more source

Synaptic Deficits Are Rescued in the p25/Cdk5 Model of Neurodegeneration by the Reduction of β-Secretase (BACE1) [PDF]

, 2011
Alzheimer's disease (AD) is the most common cause of dementia, and is characterized by memory loss and cognitive decline, as well as amyloid β (Aβ) accumulation, and progressive neurodegeneration.
Gao, Jun, Giusti-Rodriguez, Paola, Graff, Johannes, Rei, Damien, Soda, Takahiro, Tsai, Li-Huei   +5 more
core   +3 more sources