Results 101 to 110 of about 26,623 (217)

A Function for EHD Family Proteins in Unidirectional Retrograde Dendritic Transport of BACE1 and Alzheimer’s Disease Aβ Production

Cell Reports, 2013
Abnormal accumulation of β-secretase (BACE1) in dystrophic neurites and presynaptic β-amyloid (Aβ) production contribute to Alzheimer's disease pathogenesis. Little, however, is known about BACE1 sorting and dynamic transport in neurons.
Virginie Buggia-Prévot, Celia G. Fernandez, Vinod Udayar, Kulandaivelu S. Vetrivel, Aureliane Elie, Jelita Roseman, Verena A. Sasse, Margaret Lefkow, Xavier Meckler, Sohinee Bhattacharyya, Manju George, Satyabrata Kar, Vytautas P. Bindokas, Angèle T. Parent, Lawrence Rajendran, Hamid Band, Robert Vassar, Gopal Thinakaran   +17 more
doaj   +1 more source

Increased Plasma β‐Secretase 1 Activity Correlates With Neurodegeneration in Cerebral Small Vessel Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background β‐secretase 1 (BACE1) plays a key role in amyloidogenic pathway and is considered a new mechanism for cerebral small vessel disease (CSVD). We explore the potential role of plasma BACE1 in CSVD and the pathological process it may be involved ...
Ya Su, Qiong Wang, Feng Gao, Jiajie Xu, Jiayu Fu, Yunqing Ying, Yiwei Xia, Xiaoxiao Wang, Qiang Dong, Yong Shen, Xin Cheng   +10 more
doaj   +1 more source

BACE1 (β-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time

Neurobiology of Disease, 2003
The formation of Alzheimer's Aβ peptide is initiated when the amyloid precursor protein (APP) is cleaved by the enzyme β-secretase (BACE1); inhibition of this cleavage has been proposed as a means of treating Alzheimer's disease.
Yi Luo, Brad Bolon, Michael A Damore, Dan Fitzpatrick, Hantao Liu, Jianhua Zhang, Qiao Yan, Robert Vassar, Martin Citron   +8 more
doaj   +1 more source

BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

Molecular Neurodegeneration, 2018
Background β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the brains of Alzheimer’s disease (AD) patients.
WonHee Kim, Liang Ma, Selene Lomoio, Rachel Willen, Sylvia Lombardo, Jinghui Dong, Philip G. Haydon, Giuseppina Tesco   +7 more
doaj   +1 more source

BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus

Stem Cell Reports, 2017
BACE1 is validated as Alzheimer's β-secretase and a therapeutic target for Alzheimer's disease. In examining BACE1-null mice, we discovered that BACE1 deficiency develops abnormal clusters of immature neurons, forming doublecortin-positive neuroblasts ...
Hailong Hou, Qingyuan Fan, Wanxia He, Hoonkyo Suh, Xiangyou Hu, Riqiang Yan   +5 more
doaj   +1 more source

Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half‐life

Alzheimer's & Dementia, 2019
AbstractIntroductionThere is keen interest in elucidating the biological mechanisms underlying recent failures of β‐site amyloid precursor protein–cleaving enzyme‐1 (BACE1) inhibitors in Alzheimer's disease trials.MethodsWe developed a highly sensitive and specific immunoassay for BACE1 in cell lines and iPSC‐derived human neurons to systematically ...
Lei, Liu, Bianca M, Lauro, Li, Ding, Matteo, Rovere, Michael S, Wolfe, Dennis J, Selkoe   +5 more
openaire   +3 more sources

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. [PDF]

, 2019
Many risk genes for the development of Alzheimer's disease (AD) are exclusively or highly expressed in myeloid cells. Microglia are dependent on colony-stimulating factor 1 receptor (CSF1R) signaling for their survival.
Bollag, Gideon, Broome, Stephanie, Burton, Elizabeth A, Crapser, Joshua, Green, Kim N, Habets, Gaston, Hohsfield, Lindsay A, Ibrahim, Prabha, Lin, Jack, Nespi, Marika, Phan, Nicole Y, Rymar, Andrey, Severson, Paul L, Singh, Parmveer, Spangenberg, Elizabeth, Spevak, Wayne, Tsang, Garson, Walters, Jason, West, Brian L, Zhang, Chao, Zhang, Jiazhong, Zhang, Ying   +21 more
core  

Role of BACE1 in Alzheimer’s synaptic function

Translational Neurodegeneration, 2017
Alzheimer’s disease (AD) is the most common age-dependent disease of dementia, and there is currently no cure available. This hallmark pathologies of AD are the presence of amyloid plaques and neurofibrillary tangles.
Brati Das, Riqiang Yan
doaj   +1 more source

The Effects of BACE and Its Targets on Age-related Seizures in \u3cem\u3eDrosophila\u3c/em\u3e [PDF]

, 2015
The presence of Beta-Amyloid (Aβ) containing plaques in the brain is one of the histological hallmarks of Alzheimer’s Disease. β-secretase (BACE) is the enzyme responsible for producing this Aβ cleavage product and has also been shown to affect ...
Chiu, Trey Anthony, Gibbon, Dana
core   +1 more source

Caspase inhibition attenuates accumulation of β-amyloid by reducing β-secretase production and activity in rat brains after stroke

Neurobiology of Disease, 2008
In this study, we tested if caspase-3 inhibition decreased ischemia-induced Aβ elevation by reducing β-secretase (BACE1) activity. Changes in caspase-3, Aβ and BACE1 levels were detected in rat striatum on different days after middle cerebral artery ...
Man Xiong, Ting Zhang, Lin-Mei Zhang, Shi-De Lu, Ya-Lin Huang, Feng-Yan Sun   +5 more
doaj   +1 more source