Amino Acid Sequence and Structural Comparison of BACE1 and BACE2 Using Evolutionary Trace Method
The Scientific World Journal, 2014 Beta-amyloid precursor protein cleavage enzyme 1 (BACE1) and beta-amyloid precursor protein cleavage enzyme 2 (BACE2), members of aspartyl protease family, are close homologues and have high similarity in their protein crystal structures.
Hoda Mirsafian +3 more
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Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease
Molecular NeurodegenerationBackground The accumulation of β-amyloid (Aβ) peptides into insoluble plaques is an early pathological feature of Alzheimer’s disease (AD). BACE1 is the sole β-secretase for Aβ generation, making it an attractive therapeutic target for AD therapy.
Akihiro Ishii +11 more
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BACE1 inhibitors: A promising therapeutic approach for the management of Alzheimer’s disease
Asian Pacific Journal of Tropical BiomedicineAlzheimer’s disease is a neurological disorder marked by the accumulation of amyloid beta (Aβ) aggregates, resulting from mutations in the amyloid precursor protein. The enzyme β-secretase, also known as β-site amyloid precursor protein cleaving enzyme 1
Richa Arya +7 more
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Effect of Non-Coding RNA on Post-Transcriptional Gene Silencing of Alzheimer Disease [PDF]
, 2010 A large amount of hidden biological information is contained in the human genome, which is not expressed or revealed in the form of proteins; the usual end product form of gene expression.
Arun Mohan +7 more
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BACE1 paper hits 1000 citations
, 2013 I am pleased to report that our (erstwhile SmithKline Beecham) 1999 publication on the APP beta secretase identification as BACE1 (PMID 10656250), reached 1000 Google Scholar citations on the 2nd of June 2013. You can see the time course plot below. There is quite a backstory to this but I can just pick out some salient points.
openaire +1 more source
Repurposing FDA-approved drugs as multi-target neuroprotective agents for Alzheimer's disease via computational screening and experimental validation. [PDF]
Sci RepPhemphunananchai K +4 more
europepmc +1 more source
The multifaceted roles of the transcription factor <i>SP1</i> in the pathogenesis of Alzheimer's disease: From molecular regulation to therapeutic targets. [PDF]
Alzheimers Dement (N Y)Lv Z, Liu X, Huang Q, Liu H, Xu Z, Xu P.
europepmc +1 more source
Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression [PDF]
, 2019 Bateman, Randall J.
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