Results 11 to 20 of about 281,344 (286)

Triazole-Modified Nucleic Acids for the Application in Bioorganic and Medicinal Chemistry

Biomedicines, 2021
This review covers studies which exploit triazole-modified nucleic acids in the range of chemistry and biology to medicine. The 1,2,3-triazole unit, which is obtained via click chemistry approach, shows valuable and unique properties.
Dagmara Baraniak, Jerzy Boryski
doaj   +1 more source

Non-Canonical Amino Acids as Building Blocks for Peptidomimetics: Structure, Function, and Applications

Biomolecules, 2023
This review provides a fresh overview of non-canonical amino acids and their applications in the design of peptidomimetics. Non-canonical amino acids appear widely distributed in nature and are known to enhance the stability of specific secondary ...
Tarsila G. Castro, Manuel Melle-Franco, Cristina E. A. Sousa, Artur Cavaco-Paulo, João C. Marcos   +4 more
doaj   +1 more source

Nanopore Sequencing for Detection and Characterization of Phosphorothioate Modifications in Native DNA Sequences

Frontiers in Microbiology, 2022
Bacterial DNA is subject to various modifications involved in gene regulation and defense against bacteriophage attacks. Phosphorothioate (PT) modifications are protective modifications in which the non-bridging oxygen in the DNA phosphate backbone is ...
Taylor Wadley, Taylor Wadley, Sun Hee Moon, Michael S. DeMott, Visanu Wanchai, En Huang, Peter C. Dedon, Gunnar Boysen, Gunnar Boysen, Intawat Nookaew   +9 more
doaj   +1 more source

Rational design of base, sugar and backbone modifications improves ADAR-mediated RNA editing. [PDF]

Nucleic Acids Res
Lu G, Shivalila C, Monian P, Yu H, Harding I, Briem S, Byrne M, Faraone A, Friend S, Huth O, Iwamoto N, Kawamoto T, Kumarasamy J, Lamattina A, Longo K, McCarthy L, McGlynn A, Molski A, Pan Q, Pu T, Purcell-Estabrook E, Rossi J, Standley S, Thomas C, Walen A, Yang H, Kandasamy P, Vargeese C.   +27 more
europepmc   +2 more sources

Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications. [PDF]

Nat Biotechnol, 2014
Meade BR, Gogoi K, Hamil AS, Palm-Apergi C, van den Berg A, Hagopian JC, Springer AD, Eguchi A, Kacsinta AD, Dowdy CF, Presente A, Lönn P, Kaulich M, Yoshioka N, Gros E, Cui XS, Dowdy SF.   +16 more
europepmc   +2 more sources

Development of Reduced Peptide Bond Pseudopeptide Michael Acceptors for the Treatment of Human African Trypanosomiasis

Molecules, 2022
Human African Trypanosomiasis (HAT) is an endemic protozoan disease widespread in the sub-Saharan region that is caused by T. b. gambiense and T. b. rhodesiense. The development of molecules targeting rhodesain, the main cysteine protease of T.
Santo Previti, Roberta Ettari, Carla Di Chio, Rahul Ravichandran, Marta Bogacz, Ute A. Hellmich, Tanja Schirmeister, Sandro Cosconati, Maria Zappalà   +8 more
doaj   +1 more source

Phosphorylation regulates the bound structure of an intrinsically disordered protein: The p53-TAZ2 case [PDF]

, 2016
Disordered regions and Intrinsically Disordered Proteins (IDPs) are involved in critical cellular processes and may acquire a stable three-dimensional structure only upon binding to their partners.
Ithuralde, Raúl Esteban, Turjanski, Adrian   +1 more
core   +8 more sources

A photochemical C=C cleavage process: toward access to backbone N-formyl peptides

Beilstein Journal of Organic Chemistry, 2021
Photo-responsive modifications and photo-uncaging concepts are useful for spatiotemporal control of peptides structure and function. While side chain photo-responsive modifications are relatively common, access to photo-responsive modifications of ...
Haopei Wang, Zachary T. Ball
doaj   +1 more source

The Medicinal Chemistry of Artificial Nucleic Acids and Therapeutic Oligonucleotides

Pharmaceuticals, 2022
Nucleic acids play a central role in human biology, making them suitable and attractive tools for therapeutic applications. While conventional drugs generally target proteins and induce transient therapeutic effects, nucleic acid medicines can achieve ...
Miklós Bege, Anikó Borbás
doaj   +1 more source

TEMPO/TCC as a Chemo Selective Alternative for the Oxidation of Hyaluronic Acid

Molecules, 2021
Hyaluronic acid (HA)-based hydrogels are very commonly applied as cell carriers for different approaches in regenerative medicine. HA itself is a well-studied biomolecule that originates from the physiological extracellular matrix (ECM) of mammalians and,
Junwen Shan, Thomas Böck, Thorsten Keller, Leonard Forster, Torsten Blunk, Jürgen Groll, Jörg Teßmar   +6 more
doaj   +1 more source