Who Watches the Watchmen: Roles of RNA Modifications in the RNA Interference Pathway. [PDF]
PLoS Genetics, 2016 RNA levels are widely thought to be predictive of RNA function. However, the existence of more than a hundred chemically distinct modifications of RNA alone is a major indication that these moieties may impart distinct functions to subgroups of RNA ...
Samantha B Shelton +2 more
doaj +1 more source
An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and function of macromolecular complexes. [PDF]
, 2018 Mass spectrometry (MS) has become a crucial technique for the analysis of protein complexes. Native MS has traditionally examined protein subunit arrangements, while proteomics MS has focused on sequence identification.
Campuzano, Iain DG +4 more
core +1 more source
How I treat febrile neutropenia
Mediterranean Journal of Hematology and Infectious Diseases, 2021 The management of febrile neutropenia is a backbone of the treatment of patients with hematologic malignancies, and has evolved over the past decades. This article reviews my approach to the evaluation and treatment of febrile neutropenic patients.
Marcio Nucci
doaj +1 more source
Rosetta FlexPepDock to predict peptide-MHC binding: An approach for non-canonical amino acids.
PLoS ONE, 2022 Computation methods that predict the binding of peptides to MHC-I are important tools for screening and identifying immunogenic antigens and have the potential to accelerate vaccine and drug development.
Nathaniel Bloodworth +4 more
doaj +3 more sources
An efficient tomato-detection method based on improved YOLOv4-tiny model in complex environment
Frontiers in Plant Science, 2023 Automatic and accurate detection of fruit in greenhouse is challenging due to complicated environment conditions. Leaves or branches occlusion, illumination variation, overlap and cluster between fruits make the fruit detection accuracy to decrease.
Philippe Lyonel Touko Mbouembe +4 more
doaj +1 more source
Cluster counting: The Hoshen-Kopelman algorithm vs. spanning tree approaches
, 1997 Two basic approaches to the cluster counting task in the percolation and related models are discussed. The Hoshen-Kopelman multiple labeling technique for cluster statistics is redescribed.
Babalievski F. +12 more
core +1 more source
Modifications to the Peptidoglycan Backbone Help Bacteria To Establish Infection [PDF]
Infection and Immunity, 2011 ABSTRACT Bacterial pathogens that colonize mucosal surfaces have acquired resistance to antimicrobials that are abundant at these sites. One of the main antimicrobials present on mucosal surfaces is lysozyme, a muramidase that hydrolyzes the peptidoglycan backbone of bacteria.
Kimberly M, Davis, Jeffrey N, Weiser
openaire +2 more sources
Thermal degradation of citrus pectin in low-moisture environment - Influence of acidic and alkaline pre-treatment [PDF]
, 2018 Pectin powder is degraded during storage and transport by demethoxylation and depolymerisation. The degradation mechanisms and especially the influence of pre-treatments on the degradation reactions are not completely understood.
Drusch, Stephan +4 more
core +1 more source
Receptor selectivity from minimal backbone modification of a polypeptide agonist [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance G-protein-coupled receptors (GPCRs) mediate diverse physiological processes and are targets of many therapeutic agents. GPCR subfamilies comprise related receptors that can be activated by the same or similar agonists but manifest distinct functions. Subtype-selective agonists are valuable as tools for fundamental research and as
Shi Liu +4 more
openaire +2 more sources
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source