Results 21 to 30 of about 281,344 (286)
Phosphorothioate Backbone Modification Modulates Macrophage Activation by CpG DNA [PDF]
The Journal of Immunology, 2000 AbstractMacrophages respond to unmethylated CpG motifs present in nonmammalian DNA. Stabilized phosphorothioate-modified oligodeoxynucleotides (PS-ODN) containing CpG motifs form the basis of immunotherapeutic agents. In this study, we show that PS-ODN do not perfectly mimic native DNA in activation of macrophages.
Sester, D P +4 more
openaire +3 more sources
Influence of molecular structure on the antimicrobial function of phenylenevinylene conjugated oligoelectrolytes. [PDF]
, 2016 Conjugated oligoelectrolytes (COEs) with phenylenevinylene (PV) repeat units are known to spontaneously intercalate into cell membranes. Twelve COEs, including seven structures reported here for the first time, were investigated for the relationship ...
Bazan, Guillermo C +5 more
core +2 more sources
Site selective reading of epigenetic markers by a dual-mode synthetic receptor array. [PDF]
, 2017 Variably functionalized self-folding deep cavitands form an arrayed, fluorescent indicator displacement assay system for the detection of post-translationally modified (PTM) histone peptides.
Bardeen, Christopher J +8 more
core +2 more sources
Secondary-Structure Design of Proteins by a Backbone Torsion Energy [PDF]
, 2005 We propose a new backbone-torsion-energy term in the force field for protein systems. This torsion-energy term is represented by a double Fourier series in two variables, the backbone dihedral angles phi and psi.
Berendsen H. J. C. +30 more
core +2 more sources
Molecules, 2018 Deficient stability towards nuclease-mediated degradation is one of the most relevant tasks in the development of oligonucleotide-derived biomedical agents.
Melissa Meng +2 more
doaj +1 more source
Molecules, 2022 Naturally occurring phospholipids, such as phosphatidyl glycerol (PG), are gaining interest due to the roles they play in disease mechanisms. To elucidate the metabolism of PG, an optically pure material is required, but this is unfortunately not ...
Zachary J. Struzik +4 more
doaj +1 more source
Peptidomimetics and Their Applications for Opioid Peptide Drug Discovery
Biomolecules, 2022 Despite various advantages, opioid peptides have been limited in their therapeutic uses due to the main drawbacks in metabolic stability, blood-brain barrier permeability, and bioavailability.
Yeon Sun Lee
doaj +1 more source
Transcription activator like effector (TALE)-directed piggyBac transposition in human cells. [PDF]
, 2013 Insertional therapies have shown great potential for combating genetic disease and safer methods would undoubtedly broaden the variety of possible illness that can be treated. A major challenge that remains is reducing the risk of insertional mutagenesis
Bhakta, Mital S +6 more
core +3 more sources
Post-translational modifications and their implications in cancer
Frontiers in Oncology, 2023 Post-translational modifications (PTMs) are crucial regulatory mechanisms that alter the properties of a protein by covalently attaching a modified chemical group to some of its amino acid residues. PTMs modulate essential physiological processes such as
Hashnu Dutta +3 more
doaj +1 more source
Molecular modeling of an antigenic complex between a viral peptide and a class I major histocompatibility glycoprotein [PDF]
, 1992 Computer simulation of the conformations of short antigenic peptides (&lo residues) either free or bound to their receptor, the major histocompatibility complex (MHC)- encoded glycoprotein H-2 Ld, was employed to explain experimentally determined ...
Allen +38 more
core +1 more source