Results 31 to 40 of about 281,344 (286)

Oligonucleotide analogues with cationic backbone linkages

Beilstein Journal of Organic Chemistry, 2018
Their unique ability to selectively bind specific nucleic acid sequences makes oligonucleotides promising bioactive agents. However, modifications of the nucleic acid structure are an essential prerequisite for their application in vivo or even in ...
Melissa Meng, Christian Ducho
doaj   +1 more source

Inverting the Electronic Structure of Diylidylgermylenes by Backbone Modification

Chemistry – A European Journal, 2023
AbstractOwing to the strong electron‐donating ability of ylide substituents, diylidyltetrylenes are usually highly nucleophilic species with strong donor capacities. Here, we demonstrate that their electronic properties are in fact highly flexible and can be effectively tuned through variation of the substituent in the ylide backbone.
V. S. V. S. N. Swamy, Felix Krischer, Christopher Schwarz, Henning Steinert, Bert Mallick, Viktoria H. Gessner   +5 more
openaire   +2 more sources

Gi- and Gs-coupled GPCRs show different modes of G-protein binding. [PDF]

, 2018
More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin was uncovered.
Altenbach, Christian, Caro, Lydia N, Dror, Ron O, Ernst, Oliver P, Hollingsworth, Scott A, Hubbell, Wayne L, Latorraca, Naomi R, Van Eps, Ned   +7 more
core   +1 more source

NAA-modified DNA oligonucleotides with zwitterionic backbones: stereoselective synthesis of A–T phosphoramidite building blocks

Beilstein Journal of Organic Chemistry, 2015
Modifications of the nucleic acid backbone are essential for the development of oligonucleotide-derived bioactive agents. The NAA-modification represents a novel artificial internucleotide linkage which enables the site-specific introduction of positive ...
Boris Schmidtgall, Claudia Höbartner, Christian Ducho   +2 more
doaj   +1 more source

Chiral Peptide Nucleic Acids with a Substituent in the N-(2-Aminoethy)glycine Backbone

Molecules, 2012
A peptide nucleic acid (PNA) is a synthetic nucleic acid mimic in which the sugar-phosphate backbone is replaced by a peptide backbone. PNAs hybridize to complementary DNA and RNA with higher affinity and superior sequence selectivity compared to DNA ...
Atsushi Kittaka, Toru Sugiyama
doaj   +1 more source

Structural Diversity of Peptoids: Tube-Like Structures of Macrocycles

Molecules, 2020
Peptoids, or poly-N-substituted glycines, are characterised by broad structural diversity. Compared to peptides, they are less restricted in rotation and lack backbone-derived H bonding.
Claudine Nicole Herlan, Katharina Sommer, Patrick Weis, Martin Nieger, Stefan Bräse   +4 more
doaj   +1 more source

Poly (glycerol adipate) (PGA), an enzymatically synthesized functionalizable polyester and versatile drug delivery carrier : A literature update [PDF]

, 2019
The enzymatically synthesized poly (glycerol adipate) (PGA) has demonstrated all the desirable key properties required from a performing biomaterial to be considered a versatile "polymeric-tool" in the broad field of drug delivery.
Garnett, Martin C., Styliari, Ioanna Danai, Swainson, Sadie M.E., Taresco, Vincenzo   +3 more
core   +3 more sources

Backbone Fluorescent DNA Modifications: Reducing Uncertainties In FRET [PDF]

Biophysical Journal, 2009
View Large Image | View Hi-Res Image | Download PowerPoint SlideThe kappa square factor is one of several uncertainties that preclude FRET from being a true quantitative technique. Fluorescent backbone modification of DNA structure can constrain the rotational flexibility of the dyes and the orientation can be predicted from the DNA structure.
Ranjit, Suman, Levitus, Marcia
openaire   +1 more source

Solid-Phase Synthesis of Difficult Purine-Rich PNAs through Selective Hmb Incorporation: Application to the Total Synthesis of Cell Penetrating Peptide-PNAs

Frontiers in Chemistry, 2017
Antisense oligonucleotide (ASO)-based drug development is gaining significant momentum following the recent FDA approval of Eteplirsen (an ASO based on phosphorodiamidate morpholino) and Spinraza (2′-O-methoxyethyl-phosphorothioate) in late 2016.
Julien Tailhades, Julien Tailhades, Hotake Takizawa, Michael J. Gait, Don A. Wellings, John D. Wade, John D. Wade, Yoshitsugu Aoki, Fazel Shabanpoor, Fazel Shabanpoor   +9 more
doaj   +1 more source

Boosting the Performance of CDCL-Based SAT Solvers by Exploiting Backbones and Backdoors

Algorithms, 2022
Boolean structural measures were introduced to explain the high performance of conflict-driven clause-learning (CDCL) SAT solvers on industrial SAT instances.
Tasniem Al-Yahya, Mohamed El Bachir Abdelkrim Menai, Hassan Mathkour   +2 more
doaj   +1 more source