Results 51 to 60 of about 281,344 (286)

High-throughput sequencing of EcoWI restriction fragments maps the genome-wide landscape of phosphorothioate modification at base resolution.

PLoS Genetics, 2022
Phosphorothioation (PT), in which a non-bridging oxygen is replaced by a sulfur, is one of the rare modifications discovered in bacteria and archaea that occurs on the sugar-phosphate backbone as opposed to the nucleobase moiety of DNA.
Weiwei Yang, Alexey Fomenkov, Dan Heiter, Shuang-Yong Xu, Laurence Ettwiller   +4 more
doaj   +1 more source

Stacking and band structure of van der Waals bonded graphane multilayers [PDF]

, 2010
We use density functional theory and the van der Waals density functional (vdW-DF) method to determine the binding separation in bilayer and bulk graphane and study the changes in electronic band structure that arise with the multilayer formation.
Hyldgaard, Per, Rohrer, Jochen
core   +2 more sources

Backbone Modification in a Protein Hydrophobic Core

Chemistry – A European Journal
AbstractTargeted protein backbone modification can recreate tertiary structures reminiscent of folds found in nature on artificial scaffolds with improved biostability. Incorporation of altered monomers in such entities is typically limited to sites distant from the hydrophobic core to avoid potential disruptions to folding.
Yuhan Lin, W. Seth Horne
openaire   +3 more sources

Heterocyclic Peptide Backbone Modifications in an α-Helical Coiled Coil [PDF]

Journal of the American Chemical Society, 2004
In this paper, we present 1,2,3-triazole epsilon2-amino acids incorporated as a dipeptide surrogate at three positions in the sequence of a known alpha-helical coiled coil. Biophysical characterization indicates that the modified peptides retain much of the helical structure of the parent sequence, and that the thermodynamic stability of the coiled ...
W Seth, Horne, Maneesh K, Yadav, C David, Stout, M Reza, Ghadiri   +3 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Introduction to the Special Issue “Biological Efficacy of Natural and Chemically Modified Products against Oral Inflammatory Lesions”

Medicines, 2019
This editorial is a brief introduction to the Special Issue of “Biological Efficacy of Natural and Chemically Modified Products against Oral Inflammatory Lesions”.
Hiroshi Sakagami
doaj   +1 more source

Regulation of metabolism by miR-378 [PDF]

, 2014
The present invention provides a method of regulating fatty acid metabolism in a cell by contacting the cell with a modulator of miR-378 and/or miR-378* activity or expression.
Carrer, Michele, Olson, Eric N.
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A Transfer Matrix for the Backbone Exponent of Two-Dimensional Percolation [PDF]

, 2001
Rephrasing the backbone of two-dimensional percolation as a monochromatic path crossing problem, we investigate the latter by a transfer matrix approach.
Aizenman M, Baxter R J, Benettin G, Blöte H W J, Cardy J L, Cardy J L, Coniglio A, den Nijs M P M, Derrida B, Dotsenko Vl S, Enting I G, Furstenberg H, Grassberger P, Havlin S, Jacobsen J L, Jesper Lykke Jacobsen, Kasteleyn P W, Lawler G F, Motzkin T, Nienhuis B, Nienhuis B, Paul Zinn-Justin, Stauffer D   +22 more
core   +4 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source