Results 61 to 70 of about 281,344 (286)

Development of Methods Derived from Iodine-Induced Specific Cleavage for Identification and Quantitation of DNA Phosphorothioate Modifications

Biomolecules, 2020
DNA phosphorothioate (PT) modification is a novel modification that occurs on the DNA backbone, which refers to a non-bridging phosphate oxygen replaced by sulfur.
Sucheng Zhu, Tao Zheng, Lingxin Kong, Jinli Li, Bo Cao, Michael S. DeMott, Yihua Sun, Ying Chen, Zixin Deng, Peter C. Dedon, Delin You   +10 more
doaj   +1 more source

Locked nucleic acid: tighter is different [PDF]

, 2013
This viewpoint briefly reviews the impact of Locked Nucleic Acid (LNA) oligonucleotides, first described in a ChemComm paper in 1998. A number of unique applications in oligonucleotide biotechnology have been made possible by the high binding affinity ...
Watts, Jonathan
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A Visual Compendium of Principal Modifications within the Nucleic Acid Sugar Phosphate Backbone

Molecules
Nucleic acid chemistry is a huge research area that has received new impetus due to the recent explosive success of oligonucleotide therapy. In order for an oligonucleotide to become clinically effective, its monomeric parts are subjected to ...
Daria Novikova, Aleksandra Sagaidak, Svetlana Vorona, Vyacheslav Tribulovich   +3 more
doaj   +1 more source

Systematic Hydrogen‐Bond Manipulations To Establish Polysaccharide Structure–Property Correlations [PDF]

, 2019
A dense hydrogen‐bond network is responsible for the mechanical and structural properties of polysaccharides. Random derivatization alters the properties of the bulk material by disrupting the hydrogen bonds, but obstructs detailed structure–function ...
Yu, Yang, Tyrikos-Ergas, Theodore, Zhu, Yuntao, Fittolani, Giulio, Bordoni, Vittorio, Singhal, Ankush, Fair, Richard J., Grafmüller, Andrea, Seeberger, Peter H., Delbianco, Martina   +9 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

From invasion percolation to flow in rock fracture networks

, 2011
The main purpose of this work is to simulate two-phase flow in the form of immiscible displacement through anisotropic, three-dimensional (3D) discrete fracture networks (DFN).
Abelin, Adler, Araújo, Araújo, Bill Lanyon, Blunt, Broadbent, Cacas, Chandler, Dershowitz, Falk K. Wittel, Fisher, Glass, Glass, Gustafson, Hans J. Herrmann, Herrmann, Herrmann, Holt, Hunt, Hunt, Huseby, Ioannidis, Kemeny, Khamforoush, Khamforoush, Koudina, Lenormand, Makse, Mazurek, Meakin, Neuman, Normand, Nuno A.M. Araújo, Oliveira, Oliveira, Priest, Sahimi, Sahimi, Sahimi, Salomon J. Wettstein, Sheppard, Stanley, Stauffer, Wilkinson, Wilson, Xu   +46 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Enabling Distributed Simulation of OMNeT++ INET Models [PDF]

, 2014
Parallel and distributed simulation have been extensively researched for a long time. Nevertheless, many simulation models are still executed sequentially.
Bettermann, Ralf, Gross, James, Stoffers, Mirko, Wehrle, Klaus   +3 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source