Results 1 to 10 of about 36,341 (274)

Intra-Arterial, but Not Intrathecal, Baclofen and Codeine Attenuates Cough in the Cat [PDF]

Frontiers in Physiology, 2021
Centrally-acting antitussive drugs are thought to act solely in the brainstem. However, the role of the spinal cord in the mechanism of action of these drugs is unknown.
Wendy L. Olsen, Melanie Rose, Frank J. Golder, Cheng Wang, Julie C. Hammond, Donald C. Bolser   +5 more
doaj   +2 more sources

The Neuropharmacology of Baclofen [PDF]

, 1988
Gamma-aminobutyric acid (GABA) is one of the major inhibitory neurotransmitters in the mammalian central nervous system [see: 36, 69, 92, 98]. GABAergic neurons have been identified throughout the central nervous system with histochemical techniques [see: 75].
Zieglgänsberger, Walter, Howe, James R., Sutor, Bernd   +2 more
openaire   +5 more sources

Baclofen therapeutics, toxicity, and withdrawal: A narrative review

SAGE Open Medicine, 2021
Baclofen is an effective therapeutic for the treatment of spasticity related to multiple sclerosis, spinal cord injuries, and other spinal cord pathologies.
Jia Romito, Bryan T Romito
exaly   +2 more sources

Intrathecal Baclofen Infusion Pumps in the Treatment of Spasticity: A Retrospective Cohort Study in a Portuguese Centre

Acta Médica Portuguesa, 2019
Introduction: Spasticity is a complex problem in patients with neurological disorders and may distress their quality of life. Intrathecal baclofen infusion pumps reduce spasticity with low doses and minimal side effects but are not free from ...
Pedro Videira Reis, Catarina Rocha Vieira, Ana Cristina Midões, Virginia Rebelo, Paula Barbosa, Armanda Gomes   +5 more
doaj   +3 more sources

Acute Intoxication After Baclofen Administration: A Review of the Literature and Methodological Proposals. [PDF]

Toxics
Albano GD, Midiri M, Gergely PA, Harsányi TG, Racz K, Nivoli AM, Buscemi R, Zerbo S, Argo A, Trignano C.   +9 more
europepmc   +3 more sources

Severe Bradyarrhythmia and Reduced Cardiac Output Due to Oral Baclofen Withdrawal in a 24-Year Old Man: A Case Report. [PDF]

Am J Case Rep
Liyanage DS, Sivarajah J, Johnston C, Tiruvoipati R.   +3 more
europepmc   +3 more sources

Baclofen overdose [PDF]

Postgraduate Medical Journal, 1980
Summary A 57-year-old woman suffering from multiple sclerosis took an estimated 1500 mg of baclofen. She became deeply unconscious with generalized flaccid muscle paralysis and absent tendon reflexes. Toxicological analysis confirmed the presence of baclofen together with small amounts of paracetamol and glutethimide. Supportive therapy,
D J, Lipscomb, T J, Meredith
openaire   +2 more sources

Baclofen-induced myoclonus in patients with renal impairment: A case series

SAGE Open Medical Case Reports, 2023
Baclofen is a derivative of gamma amino butyric acid and is used for control of pain and muscular spasms. It is primarily excreted via the kidneys. In patients with impaired renal functions, the half-life of baclofen is prolonged and symptoms of toxicity
Manudi Nushara Vidanapathirana, Thamalee Palliyaguruge, Eranga Wijewickrama   +2 more
doaj   +1 more source

Case Report: Lateral C1-C2 puncture for intrathecal baclofen therapy: an alternative effective and safe approach after spinal cord injury. [PDF]

Front Pain Res (Lausanne)
Fawaz R, Belaid H, Eklu B, Thiebaut JB, Duraffourg M.   +4 more
europepmc   +3 more sources

Prepontine baclofen catheter placement: A case report and technical illustration

Interdisciplinary Neurosurgery, 2020
Background: Intrathecal baclofen (ITB) is used for medically refractory spasticity and dystonia. There are times when intraventricular baclofen (IVB) is used as a last resort for patients who cannot tolerate or cannot receive intrathecal baclofen through
Josue D. Ordaz, Jacob Archer, Albert Lee
doaj   +1 more source