Results 1 to 10 of about 36,785 (263)
Intra-Arterial, but Not Intrathecal, Baclofen and Codeine Attenuates Cough in the Cat [PDF]
Frontiers in Physiology, 2021 Centrally-acting antitussive drugs are thought to act solely in the brainstem. However, the role of the spinal cord in the mechanism of action of these drugs is unknown.
Wendy L. Olsen +5 more
doaj +2 more sources
Baclofen therapeutics, toxicity, and withdrawal: A narrative review
SAGE Open Medicine, 2021 Baclofen is an effective therapeutic for the treatment of spasticity related to multiple sclerosis, spinal cord injuries, and other spinal cord pathologies.
Jia Romito, Bryan T Romito
exaly +2 more sources
The use of very high-doses of baclofen for the treatment of alcohol-dependence: a case series. [PDF]
Frontiers in Psychiatry, 2014 Baclofen, particularly high-dose baclofen, has recently emerged as a treatment of major interest for alcohol-dependence. However, baclofen has many potentially dangerous side effects, and the maximal dose of baclofen that may be used is a matter of ...
Renaud ede Beaurepaire
doaj +3 more sources
Postgraduate Medical Journal, 1980 Summary A 57-year-old woman suffering from multiple sclerosis took an estimated 1500 mg of baclofen. She became deeply unconscious with generalized flaccid muscle paralysis and absent tendon reflexes. Toxicological analysis confirmed the presence of baclofen together with small amounts of paracetamol and glutethimide. Supportive therapy,
D J, Lipscomb, T J, Meredith
openaire +2 more sources
Baclofen-induced myoclonus in patients with renal impairment: A case series
SAGE Open Medical Case Reports, 2023 Baclofen is a derivative of gamma amino butyric acid and is used for control of pain and muscular spasms. It is primarily excreted via the kidneys. In patients with impaired renal functions, the half-life of baclofen is prolonged and symptoms of toxicity
Manudi Nushara Vidanapathirana +2 more
doaj +1 more source
Prepontine baclofen catheter placement: A case report and technical illustration
Interdisciplinary Neurosurgery, 2020 Background: Intrathecal baclofen (ITB) is used for medically refractory spasticity and dystonia. There are times when intraventricular baclofen (IVB) is used as a last resort for patients who cannot tolerate or cannot receive intrathecal baclofen through
Josue D. Ordaz, Jacob Archer, Albert Lee
doaj +1 more source
Mechanism of Baclofen Inhibiting the Proliferation and Metastasis of GBM by Regulating YAP
Journal of Chemistry, 2021 This study explores the effect of baclofen on the malignant phenotype of glioblastoma (GBM) and the growth of xenograft tumors and investigates the related mechanisms, aiming to reveal the effect of baclofen on the occurrence and development of GBM.
Lin Zhu, Juan Lu, Zhijun Bao, Shiwen Guo
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Frontiers in Pharmacology, 2023 Introduction: Clinical studies on the effectiveness of Baclofen in alcohol use disorder (AUD) yielded mixed results possibly because of differential effects of the enantiomers and sex-related differences.
Jérôme Jeanblanc +16 more
doaj +1 more source
Stability Study of Baclofen in an Oral Powder Form Compounded for Pediatric Patients in Japan
Children, 2022 Baclofen is used as a skeletal muscle relaxant for multiple sclerosis patients and pediatric patients with cerebral palsy and is prescribed to pediatric patients at 0.3 to 1.0 mg/kg/dose.
Jumpei Saito +7 more
doaj +1 more source
R(+)-baclofen, but not S(-)-baclofen, alters alcohol self-administration in alcohol-preferring rats
Frontiers in Psychiatry, 2016 Racemic baclofen [(±)-baclofen] has repeatedly been reported to suppress several alcohol-motivated behaviors, including alcohol drinking and alcohol self-administration, in rats and mice.
Irene eLorrai +3 more
doaj +1 more source