Results 91 to 100 of about 36,341 (274)
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Spasmodic dysphonia is a laryngeal dystonia that can present as adductor, abductor, or mixed types, with or without tremor. The etiology is not understood fully. Comprehensive evaluation is required to establish the diagnosis. Treatments include voice therapy, medications, botulinum toxin injection, laryngeal surgery, deep brain stimulation ...
Aaron J. Jaworek, Robert T. Sataloff
wiley +1 more source
Single-dose baclofen-induced neurotoxicity in a patient with end stage renal disease: case report
BMC Nephrology, 2018 Background Baclofen is a centrally acting GABAB receptor agonist and it is used widely for the treatment of spasticity, persistent hiccups and multiple sclerosis. The renal system is the main route of excretion, thus people with suboptimal renal function
Emad Khazneh +4 more
doaj +1 more source
New Aspects of Thromboangiitis obliterans (von Winiwarter-Buerger's Disease) [PDF]
, 1984 The existence of thromboangiitis obliterans as a clinical entity has been a matter of debate for many years. In contrast to other immunovasculitides there is no organ involvement while peripheral vessels are affected.
Berlit, Peter +3 more
core +1 more source
Alcohol, Clinical and Experimental Research, EarlyView.This systematic review emphasizes the critical role of GABAB receptors (GABABR) in alcohol use disorder (AUD). While GABABR agonists enhance cortical inhibition, as measured by transcranial magnetic stimulation (TMS)‐based markers, alcohol consumption alters GABABR ‐dependent neurophysiological measures, suggesting GABABR dysfunction plays a key role ...
Chiara Montemitro +4 more
wiley +1 more source
Safety Challenges of Using High Dose Baclofen for Alcohol Use Disorder: A Focused Review
Frontiers in Psychiatry, 2018 Since the early 2000s, the gamma-aminobutyric acid type B (GABA-B) receptor agonist baclofen has been extensively used for treating alcohol use disorder (AUD).
Benjamin Rolland +3 more
doaj +1 more source
Influx of Calcium through L-type Calcium Channels in Early Postnatal Regulation of Chloride Transporters in the Rat Hippocampus [PDF]
, 2009 During the early postnatal period, GABAB receptor activation facilitates L-type calcium current in rat hippocampus. One developmental process that L-type current may regulate is the change in expression of the K+Cl− co-transporter (KCC2) and N+K+2Cl− co ...
Balakrishnan +48 more
core +2 more sources
Alcohol, Clinical and Experimental Research, EarlyView.This RCT evaluated whether the glycine receptor (GlyR) agonist glycine reduces craving and alcohol intake in individuals with AUD. Despite a preclinical rationale for targeting the GlyR, these parameters were not reduced. Interestingly, glycine weakened the link between alcohol‐induced craving and self‐administration, and baseline glycine levels were ...
Yasmin Olsson +3 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post +4 more
wiley +1 more source
Non-medical use of baclofen: A case series and review of the literature [PDF]
, 2021 Jean Marc Pelerin +5 more
openalex +1 more source