Results 101 to 110 of about 36,785 (263)

Intrathecal Baclofen Infusion Pumps in the Treatment of Spasticity: A Retrospective Cohort Study in a Portuguese Centre

open access: yesActa Médica Portuguesa, 2019
Introduction: Spasticity is a complex problem in patients with neurological disorders and may distress their quality of life. Intrathecal baclofen infusion pumps reduce spasticity with low doses and minimal side effects but are not free from ...
Pedro Videira Reis   +5 more
doaj   +1 more source

Targeting the SIRT1‐NAT10‐GABABR1 Axis: A Novel Epitranscriptomic Approach to Mitigate Sevoflurane‐Induced Cognitive Impairment in Aging

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
The study reveals that NAT10 enhances GABABR1 mRNA stability via ac4A modification, leading to excessive inhibitory synaptic activation. In aged rats, sevoflurane contributes to cognitive impairment by inhibiting Sirt1 and neuronal autophagy, which subsequently disrupts energy metabolism.
Xin Xie   +3 more
wiley   +1 more source

Leg Sympathetic Response to Noxious Skin Stimuli is Similar in High and Low Level Human Spinal Cord Injury [PDF]

open access: yes, 2008
Objective To determine if sympathetically mediated vasoconstriction in the lower extremities is injury level dependent. Although sympathetic responses have been measured in the limbs of people with high and low level SCI using blood flow measurements ...
Garrison, M. Kevin   +2 more
core   +1 more source

An autocrine role for pituitary GABA: Activation of GABA-B receptors and regulation of growth hormone levels [PDF]

open access: yes, 2002
There is increasing evidence suggesting that the neurotransmitter gamma-aminobutyric acid (GABA) is a local factor involved in the regulation of endocrine organs.
Corsi, C.   +5 more
core   +1 more source

Assessment of Health Care Costs and Total Baclofen Use Associated With Targeted Drug Delivery for Spasticity [PDF]

open access: green, 2023
Vishal Venkatraman   +6 more
openalex   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo   +11 more
wiley   +1 more source

Untersuchung neuroprotektiver Effekte der intrathekalen Baclofenapplikation [PDF]

open access: yes, 2006
Cerebral-ischämische Erkrankungen nehmen eine wichtige Rolle bei der Versorgung neurologischer und neurochirurgischer Patienten ein. Sie sind darüberhinaus ein enormer gesundheitsökonomischer Faktor.
Becker, Ralf (Dr.), Ludolph, Alexander
core   +1 more source

Procedural separation of appetitive and consummatory behaviors in operant ethanol self‐administration: A review and open‐source analytical framework

open access: yesAlcohol, Clinical and Experimental Research, Volume 50, Issue 2, February 2026.
This review highlights the biphasic sipper model pioneered by Dr. Hank Samson's laboratory, which separates appetitive and consummatory behaviors in rodent ethanol self‐administration. Over two decades of research using this paradigm reveals that alcohol‐directed behaviors are dynamic, shaped by internal states, cues, and experience.
Olivia A. Colarusso, Jeffrey L. Weiner
wiley   +1 more source

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