Systemic and intrathecal baclofen produce bladder antinociception in rats
BMC Urology, 2021 Background Baclofen, a clinically available GABAB receptor agonist, produces non-opioid analgesia in multiple models of pain but has not been tested for effects on bladder nociception.
Timothy J. Ness +4 more
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Current Perspective on the Location and Function of Gamma- Aminobutyric Acid (GABA) and its Metabolic Partners in the Kidney. [PDF]
, 2014 Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter located in the mammalian central nervous system, which binds to GABAA and GABAB receptors to mediate its neurological effects.
Dunn, Kadeshia +3 more
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The Effect of Ginkgo on Baclofen Induced Amnesia using Passive Avoidance Learning and Memory in Rats [PDF]
Journal of Fasa University of Medical Sciences, 2015 Background & Objective: Ginkgo biloba is an herbal medicine that has a positive effect on improving memory. It prevents oxidative damage in mitochondria and cell death in a variety of Neuropathies.
Elaheh Nooshinfar +3 more
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Neonatal baclofen withdrawal following intrauterine exposure
Journal of Pediatric Rehabilitation Medicine, 2022 BACKGROUND: Pregnant women with spinal cord injuries are often advised to continue oral baclofen during pregnancy to manage spasticity, though the potential for adverse events in neonates is not well understood.
Marianne A. Mousigian +3 more
doaj +1 more source
Beneficial effects of childhood selective dorsal rhizotomy in adulthood [PDF]
, 2017 Background: Selective dorsal rhizotomy (SDR) has been used to treat children with spastic cerebral palsy (CP) for over three decades. However, little is known about the outcomes of childhood SDR in adults.
Dobbs, Matthew B +4 more
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How to Manage Self-Poisoning With Baclofen in Alcohol Use Disorder? Current Updates
Frontiers in Psychiatry, 2018 Specialists in addiction medicine continue to debate whether baclofen is still indicated to treat alcohol use disorders in view of conflicting results as to its efficacy.
Nicolas Franchitto +6 more
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Solubility of baclofen in 1-hexyl-4-methylpyridinium bromide + water binary mixtures [PDF]
شیمی کاربردی روز, 2017 In this paper, solubility of baclofen was studied by gravimetric method. The solubility of baclofen was measured in (water + 1-hexyl-4-methylpyridinium bromide) binary mixtures from 293.1 K to 313.1 K under atmosphere pressure.
Abbas Mehrdad +2 more
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Bidirectional enantioselective effects of the GABAB receptor agonist baclofen in two mouse models of excessive ethanol consumption [PDF]
, 2015 The GABAB receptor agonist baclofen has been studied extensively in preclinical models of alcohol-use disorders, yet results on its efficacy have been uncertain.
Blasingame, Shelby N. +2 more
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Baclofen overdose presenting as psychosis with catatonia
Indian Journal of Psychological Medicine, 2017 Baclofen is a centrally acting gamma-aminobutyric acid receptor agonist with many therapeutic uses in neurology and psychiatry. An overdose of baclofen is known to cause serious side effects such as encephalopathy, seizures, respiratory depression, and ...
Abhinav Nahar +5 more
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GABAB receptor ligands for the treatment of alcohol use disorder: preclinical and clinical evidence. [PDF]
, 2014 The present paper summarizes the preclinical and clinical studies conducted to define the "anti-alcohol" pharmacological profile of the prototypic GABAB receptor agonist, baclofen, and its therapeutic potential for treatment of alcohol use disorder (AUD).
Agabio R, Colombo G
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