Results 61 to 70 of about 36,785 (263)

Correlation between the single, high dose of ingested baclofen and clinical symptoms

Annals of Agricultural and Environmental Medicine, 2017
Introduction and Objectives Baclofen is a drug used mainly to treat muscle spasticity. Its overdose can lead to life-threatening clinical symptoms, including acute respiratory failure requiring mechanical ventilation.
Jacek Sein Anand, Maciej Zając, Wojciech Waldman, Andrzej Wojtyła, Przemysław Biliński, Barbara Jaworska-Łuczak   +5 more
doaj   +1 more source

Severe Case of Oral Baclofen Withdrawal Resulting in Mechanical Ventilation

Journal of Investigative Medicine High Impact Case Reports, 2022
Abrupt baclofen withdrawal may be life-threatening with varied neuropsychiatric manifestations. We present a case of baclofen withdrawal necessitating intubation.
Resha Khanal, Sharad Oli, Janet Chan Gomez, Sahar Tahir, Binita Bhandari, Saketram Komanduri   +5 more
doaj   +1 more source

GABA-B controls persistent Na+ current and coupled Na+-activated K+ current [PDF]

, 2017
The GABA-B receptor is densely expressed throughout the brain and has been implicated in many CNS functions and disorders, including addiction, epilepsy, spasticity, schizophrenia, anxiety, cognitive deficits, and depression, as well as various aspects ...
Butler, Alice, Gonzalez-Cota, Ana Laura, Harmon, Steve, Li, Ping, Salkoff, Lawrence, Stewart, Richard   +5 more
core   +2 more sources

Expanding the Genetic and Phenotypic Spectrum of DYT‐VPS16: The Importance of Splice‐Site Variants

Movement Disorders, EarlyView.
Abstract Background DYT‐VPS16, an early‐onset isolated dystonia caused by variants in the VPS16 gene, has been reported in fewer than 70 patients. Methods We explored the clinical and genotypic spectrum of DYT‐VPS16 by investigating early‐onset dystonia patients with VPS16 variants discovered in our large Biodatabank and through gene‐matching ...
Ana Westenberger, Edgard Verdura, Mandy Radefeldt, Leslie E. Sanderson, Kornelia Tripolszki, Anna Marcé‐Grau, Ana Cazurro‐Gutiérrez, Anita Nikoncuk, Rebecca Herzog, Ruslan Al‐Ali, Mariana Ferreira, Ligia S. Almeida, Tainá Regina Damaceno Silveira, Suliman Khan, Raphael Doyle Maia, Péter Klivényi, András Salamon, Volkan Baltaci, Asli Subasioglu, Jeanette Prada‐Arismendy, Goran Čuturilo, Sebastian Loens, Vera Tadic, Isabelle Maystadt, Deniz Karadurmus, Barbara Leube, Jonathan De Winter, Alice Monticelli, Liesbeth De Waele, Jonathan Baets, Mateja Vinkšel, Aleš Maver, Lorena Tschopp, Gabriela Ziegler, Ana Sanguinetti, Katja Lohmann, Tahsin Stefan Barakat, Peter Bauer, Belén Perez‐Dueñas, Aida M. Bertoli‐Avella   +39 more
wiley   +1 more source

Using Baclofen to Explore GABA-B Receptor Function in Alcohol Dependence: Insights From Pharmacokinetic and Pharmacodynamic Measures

Frontiers in Psychiatry, 2018
Background: The role of GABA-B neurotransmission in addiction has recently received increased attention, with clinical trials indicating that baclofen, a GABA-B receptor agonist, may reduce alcohol consumption, craving and promote abstinence.
Claire F. Durant, Louise M. Paterson, Sam Turton, Susan J. Wilson, James F. M. Myers, Suresh Muthukumaraswamy, Ashwin Venkataraman, Inge Mick, Susan Paterson, Tessa Jones, Limon K. Nahar, Rosa E. Cordero, David J. Nutt, Anne Lingford-Hughes   +13 more
doaj   +1 more source

Pituitary Adenylate-Cyclase Activating Polypeptide Regulates Hunger- and Palatability-Induced Binge Eating [PDF]

, 2016
While pituitary adenylate cyclase activating polypeptide (PACAP) signaling in the hypothalamic ventromedial nuclei (VMN) has been shown to regulate feeding, a challenge in unmasking a role for this peptide in obesity is that excess feeding can involve ...
Baker, David A., Block, Megan E., Chen, Yao, Choi, Sujean, Hurley, Matthew M., Kim, Eugene, Li, Yan, Liu, Qing-Song, Maunze, Brian, Reilly, Michael J.   +9 more
core   +1 more source

Polyelectromyography Under Propofol to Differentiate Functional from Idiopathic Dystonia: A Pilot Study

Movement Disorders, EarlyView.
Abstract Background Functional dystonia (FD) is one of the most diagnostically challenging functional movement disorders. Phenomenological features often lack specificity, as many are also observed in idiopathic dystonia (ID) and validated biomarkers to distinguish FD from ID are currently unavailable Objective To investigate potential differences in ...
Roberto Eleopra, Fabio Paio, Sara Rinaldo, Carla Carozzi, Amanda Oriana, Grazia Devigili, Luigi Michele Romito, Roberto Cilia, Nico Golfrè Andreasi, Gianfranco Gaudiano, Marta Corradi, Antonio Emanuele Elia, Fabiana Colucci, Arianna Braccia, Roberta Telese, Michele Tinazzi, Marco Gemma, Valentina Leta   +17 more
wiley   +1 more source

Central sleep apnea caused by low dosage of baclofen: a case report

Journal of Medical Case Reports
Background Baclofen can relax muscle spasticity by inhibiting the transmission of both mono- and polysynaptic reflexes at the spinal cord. It has been increasingly used off-label for the management of spinal cord lesions or neurologic disorders. However,
Xiaoqiong Luo, Qidi Ding, Yanan Liu, Fang Han, Chenyu Li, Xiaosong Dong   +5 more
doaj   +1 more source

Protective effect of baclofen on ovarian cystogenesis and morphine-induced lipid profile change in female rats

Indian Journal of Endocrinology and Metabolism
Introduction: Morphine induces ovarian cysts that cause obesity and disrupt sex hormone secretion. Baclofen, a gamma-aminobutyric acid receptor agonist, can help regulate sex hormones and reduce harmful blood lipids by protecting against morphine-induced
Zahra Jamshidi, Manizheh Karami, Mohsen Khalili, Mehrdad Roghani   +3 more
doaj   +1 more source

Baclofen overdose: A curious case of medical sales representative

Clinical Case Reports, 2022
In this case report, a medical sales representative consumed 250 mg of Baclofen out of curiosity. Baclofen has life‐threatening complications like seizures, respiratory depression, and coma.
Swotantra Gautam, Aakash Neupane, Mandita Chamlagain, Sandip Pokhrel, Durga Neupane, Rochana Acharya, Sagar Panthi   +6 more
doaj   +1 more source