Endophilin-A1 BAR domain interaction with arachidonyl CoA [PDF]
Frontiers in Molecular Biosciences, 2014 Endophilin-A1 belongs to the family of BAR domain containing proteins that catalyze membrane remodeling processes via sensing, inducing and stabilizing membrane curvature.
Maxim V. Petoukhov +3 more
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Purification of Recombinant Human Amphiphysin 1 and its N-BAR Domain [PDF]
Bio-Protocol, 2023 Bin/Amphiphysin/Rvs (BAR) proteins are known as classical membrane curvature generators during endocytosis. Amphiphysin, a member of the N-BAR sub-family of proteins that contain a characteristic amphipathic sequence at the N-terminus of the BAR domain ...
Samsuzzoha Mondal +4 more
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Ca2+ Regulates Dimerization of the BAR Domain Protein PICK1 and Consequent Membrane Curvature [PDF]
Frontiers in Molecular Neuroscience, 2022 Bin-Amphiphysin-Rvs (BAR) domain proteins are critical regulators of membrane geometry. They induce and stabilize membrane curvature for processes, such as clathrin-coated pit formation and endosomal membrane tubulation.
Georgiana F. Stan +3 more
doaj +2 more sources
The ArfGAP ASAP1 Controls Actin Stress Fiber Organization via Its N-BAR Domain [PDF]
iScience, 2019 Summary: ASAP1 is a multi-domain ArfGAP that controls cell migration, spreading, and focal adhesion dynamics. Although its GAP activity contributes to remodeling of the actin cytoskeleton, it does not fully explain all cellular functions of ASAP1.
Anjelika Gasilina +4 more
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Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis [PDF]
The Journal of Clinical Investigation, 2022 Bin/amphiphysin/Rvs (BAR) domains are positively charged crescent-shaped modules that mediate curvature of negatively charged lipid membranes during remodeling processes.
Rita C. Andersen +21 more
doaj +2 more sources
A bacterial membrane sculpting protein with BAR domain-like activity [PDF]
eLife, 2021 Bin/Amphiphysin/RVS (BAR) domain proteins belong to a superfamily of coiled-coil proteins influencing membrane curvature in eukaryotes and are associated with vesicle biogenesis, vesicle-mediated protein trafficking, and intracellular signaling. Here, we
Daniel A Phillips +13 more
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Dendritic Spine Initiation in Brain Development, Learning and Diseases and Impact of BAR-Domain Proteins [PDF]
Cells, 2021 Dendritic spines are small, bulbous protrusions along neuronal dendrites where most of the excitatory synapses are located. Dendritic spine density in normal human brain increases rapidly before and after birth achieving the highest density around 2–8 ...
Pushpa Khanal, Pirta Hotulainen
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The F-BAR Domain of Rga7 Relies on a Cooperative Mechanism of Membrane Binding with a Partner Protein during Fission Yeast Cytokinesis [PDF]
Cell Reports, 2019 Summary: F-BAR proteins bind the plasma membrane (PM) to scaffold and organize the actin cytoskeleton. To understand how F-BAR proteins achieve their PM association, we studied the localization of a Schizosaccharomyces pombe F-BAR protein Rga7, which ...
Yajun Liu +4 more
doaj +2 more sources
The Predicted Structure of S. cerevisiae Ssp1 Reveals Parallel Evolution in the Pil1 BAR Domain Family Proteins of Ascomycetes [PDF]
Journal of FungiBAR domains are a superfamily of widely conserved membrane binding motifs. In fungi, Pil1 family proteins are BAR domain containing proteins involved in organizing the plasma membrane. S.
Yasuyuki Suda, Aaron M. Neiman
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Salt Bridge Formation between the I-BAR Domain and Lipids Increases Lipid Density and Membrane Curvature [PDF]
Scientific Reports, 2017 The BAR domain superfamily proteins sense or induce curvature in membranes. The inverse-BAR domain (I-BAR) is a BAR domain that forms a straight “zeppelin-shaped” dimer.
Kazuhiro Takemura +3 more
doaj +2 more sources