Results 51 to 60 of about 13,750 (173)
Brain HemorrhagesObjective: Rebleeding from a ruptured aneurysm is a risk factor for fatal prognosis in subarachnoid hemorrhage (SAH). A novel barbiturate treatment, step-down infusion of barbiturate (sd-B), was previously developed; it showed beneficial effects on ...
Sosho Kajiwara +3 more
doaj +1 more source
Journal of Sleep Research, EarlyView.ABSTRACT The 2019 coronavirus (COVID‐19) pandemic and associated lockdowns significantly disrupted healthcare systems, including access to pharmacological treatments such as sleep medication. This study investigated the number of first‐time dispensed hypnotic drugs during the first COVID‐19 lockdown in the Netherlands, using data from the Dutch ...
Dana M. Dijkgraaf +5 more
wiley +1 more source
Experimental Physiology, EarlyView.Abstract The effects of muscle disuse on the propagation of action potentials along motor unit (MU) muscle fibres, a key process for effective muscle activation and force generation, remain poorly understood. The aim of this study was to investigate changes in action potential propagation and to identify biological factors influencing these changes ...
Giacomo Valli +12 more
wiley +1 more source
Exercise during 14 days of head down tilt bedrest attenuates motor unit impairments in older humans
Experimental Physiology, EarlyView.Abstract Head‐down tilt bedrest (HDBR) models the effects of mechanical unloading on neuromuscular function. The efficacy of exercise in preserving motor unit (MU) function in older adults during HDBR remains unclear. This study investigated the effects of 14‐day HDBR on MU properties in older adults and the protective role of exercise.
Philippe St‐Martin +8 more
wiley +1 more source
Acta Crystallographica Section E, 2013 The title compound, C15H18N4O7, is a product of the substitution reaction of 5,5-dibromo-1,3-dimethylbarbituric acid with sodium sulfide in aqueous acetone.
Manfred Steimann, Kamal Sweidan
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The Journal of Physiology, EarlyView.Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite +9 more
wiley +1 more source
An Interesting Case of Barbiturate Automatism and Review of Literature
Case Reports in Neurological Medicine, 2013 A 48 year old man with a diagnosis of HIV infection since 1993, on highly active anti-retro viral therapy (HAART) with stable CD4 count and undetectable viral load for years and seizure disorder presented with recurrent drowsiness. His seizures were well
Sankalp Gokhale, Ciro Ramos-Estebanez
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International Journal of Electrochemical Science, 2012 Three potentiometric sensors responsive to Memantine HCl (MEM) drug are described, characterized, compared and used for drug assessment. The sensors are based on the use of the ion-association complex of (MEM) cation with Flavianate (FA), 5-Nitro ...
Rasha M. El Nashar +2 more
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Distinctive neurophysiological correlates of sound onset and offset perception in humans
The Journal of Physiology, EarlyView.Abstract figure legend Electroencephalography (EEG) recordings were obtained from participants listening to successive pairs of 1‐2 s noises in a silent background (Study 1) or successive pairs 1‐2 s silent gaps in a noise background (Study 2). Participants heard the same stimuli in the context of either a duration discrimination task (identifying ...
Fatima Ali +3 more
wiley +1 more source
Clonidine-Activation of Epileptic Foci
Pediatric Neurology Briefs, 1998 The effects of clonidine, an adrenergic a2 agonist hypotensive agent, and methoxital, a short-acting barbiturate anesthetic, on epileptiform discharges detected by presurgical magnetoencephalography (MEG) were investigated in 14 patients with medically ...
J Gordon Millichap
doaj +1 more source