Results 91 to 100 of about 515,050 (293)
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Investigations into the Cellular Mechanisms of Base Editing [PDF]
, 2023 The development of CRISPR-derived genome editing technologies enables precise manipulation of DNA sequences within the human genome. One class of these editing tools is base editors, which install point mutations with high efficiency and specificity ...
Burnett, Cameron
core
In the business of base editors: Evolution from bench to bedside
PLoS Biology, 2023 With the advent of recombinant DNA technology in the 1970s, the idea of using gene therapies to treat human genetic diseases captured the interest and imagination of scientists around the world.
Elizabeth M. Porto, Alexis C. Komor
doaj
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Base editing of organellar DNA with programmable deaminases
, 2023 Mitochondria and chloroplasts are organelles that include their own genomes, which encode key genes for ATP production and carbon dioxide fixation, respectively.
Jia Chen +3 more
core +1 more source
Agent-Based Model of Genotype Editing
Evolutionary Computation, 2007 Evolutionary algorithms rarely deal with ontogenetic, non-inherited alteration of genetic information because they are based on a direct genotype-phenotype mapping. In contrast, several processes have been discovered in nature which alter genetic information encoded in DNA before it is translated into amino-acid chains. Ontogenetically altered genetic
Chien-Feng Huang +3 more
openaire +4 more sources
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
DNA and RNA base editors can correct the majority of pathogenic single nucleotide variants
npj Genomic MedicineThe majority of human genetic diseases are caused by single nucleotide variants (SNVs) in the genome sequence. Excitingly, new genomic techniques known as base editing have opened efficient pathways to correct erroneous nucleotides.
Ariel Dadush +8 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
mtDNA base editing: Mind the gap
In this issue of Molecular Cell, Xiang et al. provided insights into the mechanism and structure-guided engineering of DdCBE for mitochondrial DNA base editing.
Barrera-Paez, Jose Domingo +1 more
core +1 more source