Results 81 to 90 of about 4,580,472 (190)

Agent-Based Model of Genotype Editing

Evolutionary Computation, 2007
Evolutionary algorithms rarely deal with ontogenetic, non-inherited alteration of genetic information because they are based on a direct genotype-phenotype mapping. In contrast, several processes have been discovered in nature which alter genetic information encoded in DNA before it is translated into amino-acid chains. Ontogenetically altered genetic
Chien-Feng Huang, Jasleen Kaur 0002, Ana Gabriela Maguitman, Luis M. Rocha   +3 more
openaire   +5 more sources

Efficient Generation of Pathogenic A-to-G Mutations in Human Tripronuclear Embryos via ABE-Mediated Base Editing

Molecular Therapy: Nucleic Acids, 2019
Base editing systems show their power in modeling and correcting the pathogenic mutations of genetic diseases. Previous studies have already demonstrated the editing efficiency of BE3-mediated C-to-T conversion in human embryos.
Guanglei Li, Xinyi Liu, Shisheng Huang, Yanting Zeng, Guang Yang, Zongyang Lu, Yu Zhang, Xu Ma, Lisheng Wang, Xingxu Huang, Jianqiao Liu   +10 more
doaj   +1 more source

Double-strand break-free and transgene-free genome editing in the microalga Nannochloropsis oceanica using removable vectors containing the CRISPR base editing system

Scientific Reports
The accumulation of lipids by algae makes them attractive for carbon-neutral fuel production; however, the industrial-scale production of algal lipids has yet to be achieved.
Keishi Moroi, Takashi Yamamoto, Tomokazu Kurita   +2 more
doaj   +1 more source

Assessment of proofreading and editing with technical diploma students at Western Wisconsin Technical College - Mauston [PDF]

, 1999
Plan BProofreading and editing are a major component of the Office Assistant program. The practices of proofreading and editing are an integral part of primary skills employers expect from their employees. The ability to proofread and edit a document are
Walsh-Betthauser, Kimberly
core  

Deep learning models incorporating endogenous factors beyond DNA sequences improve the prediction accuracy of base editing outcomes

Cell Discovery
Adenine base editors (ABEs) and cytosine base editors (CBEs) enable the single nucleotide editing of targeted DNA sites avoiding generation of double strand breaks, however, the genomic features that influence the outcomes of base editing in vivo still ...
Tanglong Yuan, Leilei Wu, Shiyan Li, Jitan Zheng, Nana Li, Xiao Xiao, Haihang Zhang, Tianyi Fei, Long Xie, Zhenrui Zuo, Di Li, Pinzheng Huang, Hu Feng, Yaqi Cao, Nana Yan, Xinming Wei, Lei Shi, Yongsen Sun, Wu Wei, Yidi Sun, Erwei Zuo   +20 more
doaj   +1 more source

Breaking genetic shackles: The advance of base editing in genetic disorder treatment

Frontiers in Pharmacology
The rapid evolution of gene editing technology has markedly improved the outlook for treating genetic diseases. Base editing, recognized as an exceptionally precise genetic modification tool, is emerging as a focus in the realm of genetic disease therapy.
Fang Xu, Fang Xu, Caiyan Zheng, Caiyan Zheng, Weihui Xu, Weihui Xu, Shiyao Zhang, Shiyao Zhang, Shanshan Liu, Shanshan Liu, Xiaopeng Chen, Xiaopeng Chen, Kai Yao, Kai Yao   +13 more
doaj   +1 more source

In Vivo Base Editing of Scn5a Rescues Type 3 Long QT Syndrome in Mice

reservedLa sindrome del QT lungo è una patologia genetica causata dalla mutazione di alcuni geni codificanti canali ionici del cuore, tra cui Scn5a. Questa sindrome causa aritmie cardiache e, nei casi più gravi, torsioni di punta e morte prematura dell’
GELAIN, MATTEO
core  

In vivo precision base editing to rescue mouse models of disease

Molecular Therapy: Nucleic Acids
CRISPR base editing enables precise, irreversible base conversions without inducing double-stranded breaks (DSBs) and has gained significant attention in recent years. By converting cytosine to thymine (C→T) or adenine to guanine (A→G), base editors (BEs)
Aaron Schindeler, Julian Chu, Christal Au-Yeung, Hsien-Yin Kao, Samantha L. Ginn, Alexandra K. O’Donohue   +5 more
doaj   +1 more source

Editing Medical Data Records with a Natural Language Interface [PDF]

, 2007
Power R, Pietsch C. Editing Medical Data Records with a Natural Language Interface. Presented at the Accepted for presentation at the 2nd International Symposium on Languages in Biology and Medicine (LBM) 2007, Matrix, Biopolis, Singapore.Background ...
Pietsch, Christian ; https://orcid.org/, Power, Richard   +1 more
core  

CRISPR-guided base editor enables efficient and multiplex genome editing in bacterial cellulose-producing Komagataeibacter species

Applied and Environmental Microbiology
Bacterial cellulose (BC) is an extracellular polysaccharide produced by bacteria that has wide applications in the food industry, tissue engineering, and battery manufacturing.
Bo Xin, Jiaheng Liu, Jinyang Li, Zhaojun Peng, Xinyue Gan, Yuxi Zhang, Cheng Zhong   +6 more
doaj   +1 more source