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Base excision repair in sugarcane [PDF]
Genetics and Molecular Biology, 2001 DNA damage can be induced by a large number of physical and chemical agents from the environment as well as compounds produced by cellular metabolism.
Agnez-Lima Lucymara F. +3 more
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Nature Communications, 2018 PARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair ...
George E. Ronson +7 more
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Base excision repair and the role of
Hereditary Cancer in Clinical Practice, 2007 The correction of exogenous and endogenous environmental insult to DNA involves a series of DNA repair mechanisms that reduce the likelihood of mutation accumulation and hence an increased probability of tumour development.
Kairupan Carla, Scott Rodney J
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OGG1 in Lung—More than Base Excision Repair [PDF]
Antioxidants, 2022 As the organ executing gas exchange and directly facing the external environment, the lungs are challenged continuously by various stimuli, causing the disequilibration of redox homeostasis and leading to pulmonary diseases.
Xiaodi Ma +6 more
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DNA Base Excision Repair Intermediates Influence Duplex–Quadruplex Equilibrium [PDF]
Molecules, 2023 Although genomic DNA is predominantly duplex under physiological conditions, particular sequence motifs can favor the formation of alternative secondary structures, including the G-quadruplex.
Mark L. Sowers +5 more
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A role for p53 in base excision repair [PDF]
The EMBO Journal, 2001 Wild-type p53 protein can markedly stimulate base excision repair (BER) in vitro, either reconstituted with purified components or in extracts of cells. In contrast, p53 with missense mutations either at hot-spots in the core domain or within the N-terminal transactivation domain is defective in this function.
Jian‐Min Zhou
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Base Excision Repair in the Mitochondria [PDF]
Journal of Cellular Biochemistry, 2015 ABSTRACTThe 16.5 kb human mitochondrial genome encodes for 13 polypeptides, 22 tRNAs and 2 rRNAs involved in oxidative phosphorylation. Mitochondrial DNA (mtDNA), unlike its nuclear counterpart, is not packaged into nucleosomes and is more prone to the adverse effects of reactive oxygen species (ROS) generated during oxidative phosphorylation. The past
Aishwarya Prakash, S. Doublié
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Base excision repair of DNA in mammalian cells [PDF]
FEBS Letters, 2000 Base excision repair (BER) of DNA corrects a number of spontaneous and environmentally induced genotoxic or miscoding base lesions in a process initiated by DNA glycosylases. An AP endonuclease cleaves at the 5′ side of the abasic site and the repair process is subsequently completed via either short patch repair or long patch repair, which largely ...
Hans E. Krokan +4 more
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Targeting the 8-oxodG Base Excision Repair Pathway for Cancer Therapy [PDF]
CellsGenomic integrity is critical for cellular homeostasis, preventing the accumulation of mutations that can drive diseases such as cancer. Among the mechanisms safeguarding genomic stability, the Base Excision Repair (BER) pathway plays a pivotal role in ...
Anna Piscone +6 more
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DNA Ligase C and Prim-PolC participate in base excision repair in mycobacteria
Nature Communications, 2017 Ligase D is a conserved DNA repair protein complex that repairs double-strand breaks in stationary phase prokaryotes. Here the authors show that orthologous Ligase C has a role in base excision repair during stationary phase.
Przemysław Płociński +7 more
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