Protein–Protein Interactions in Base Excision Repair [PDF]
BiomoleculesThe Base Excision Repair (BER) pathway involves a highly coordinated series of protein–protein interactions that facilitate the recognition, excision, and repair of damaged bases. Key enzymes such as DNA glycosylases, apurinic/apyrimidinic endonuclease 1
Govardhan Rathnaiah, Joann B. Sweasy
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Base excision repair in sugarcane [PDF]
Genetics and Molecular Biology, 2001 DNA damage can be induced by a large number of physical and chemical agents from the environment as well as compounds produced by cellular metabolism.
Agnez-Lima Lucymara F. +3 more
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Targeting the 8-oxodG Base Excision Repair Pathway for Cancer Therapy [PDF]
CellsGenomic integrity is critical for cellular homeostasis, preventing the accumulation of mutations that can drive diseases such as cancer. Among the mechanisms safeguarding genomic stability, the Base Excision Repair (BER) pathway plays a pivotal role in ...
Anna Piscone +6 more
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Biochemical Effects of Natural and Nanoparticle Fish and Algal Oils in Gilt Pregnancy Diets on Base Excision Repair Enzymes in Newborn Piglets-Socioeconomic Implications for Regional Pig Farming-Preliminary Results. [PDF]
Int J Mol SciKowalczyk P +6 more
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Base-Excision Repair Mutational Signature in Two Sebaceous Carcinomas of the Eyelid [PDF]
Genes (Basel), 2023 Sangiorgi E +10 more
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Dynamic features of human mitochondrial DNA maintenance and transcription
Frontiers in Cell and Developmental Biology, 2022 Mitochondria are the primary sites for cellular energy production and are required for many essential cellular processes. Mitochondrial DNA (mtDNA) is a 16.6 kb circular DNA molecule that encodes only 13 gene products of the approximately 90 different ...
Mansour Akbari +4 more
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Resistance to Nucleotide Excision Repair of Bulky Guanine Adducts Opposite Abasic Sites in DNA Duplexes and Relationships between Structure and Function. [PDF]
PLoS ONE, 2015 The nucleotide excision repair of certain bulky DNA lesions is abrogated in some specific non-canonical DNA base sequence contexts, while the removal of the same lesions by the nucleotide excision repair mechanism is efficient in duplexes in which all ...
Zhi Liu +6 more
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Abstract OR-3: Fleeting Ensembles: Transient Protein-Protein Interactions in DNA Repair [PDF]
International Journal of Biomedicine, 2019 Background: DNA repair is a vitally important process that protects the cell’s genome from ongoing damage. Six DNA repair pathways are commonly outlined: direct reversal, base excision repair, nucleotide excision repair, mismatch repair, recombination ...
Dmitry O. Zharkov
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Effect of kynurenic acid on enzymatic activity of the DNA base excision repair pathway in specific areas of the sheep brain. [PDF]
Sci RepMłotkowska P +3 more
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Cold Spring Harbor Perspectives in Biology, 2013 Base excision repair (BER) corrects DNA damage from oxidation, deamination and alkylation. Such base lesions cause little distortion to the DNA helix structure. BER is initiated by a DNA glycosylase that recognizes and removes the damaged base, leaving an abasic site that is further processed by short-patch repair or long-patch repair that largely uses
Hans E, Krokan, Magnar, Bjørås
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