Results 91 to 100 of about 967,825 (378)
OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos
Cell Death and Disease, 2018 Oxidative stress-induced DNA damage has been well acknowledged as a major cause leading to cell death, which is etiologically linked to ischemic injury and degenerative alterations.
Ruoxi Wang +9 more
semanticscholar +1 more source
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
Pluripotent cells display enhanced resistance to mutagenesis
Stem Cell Research, 2017 Pluripotent cells have been reported to exhibit lower frequencies of point mutations and higher levels of DNA repair than differentiated cells. This predicts that pluripotent cells are less susceptible to mutagenic exposures than differentiated cells. To
Daniel J. Cooper +5 more
doaj +1 more source
Base excision repair in Alzheimer’s disease
Postępy Higieny i Medycyny Doświadczalnej, 2014 Alzheimer's disease (AD) is the most common neurodegenerative disease in people over 65 years of age. Estimates indicate that about 200 thousand Pole suffer from AD while in the world about 30 million people. Forecasts show that in developed countries the number of people with neurodegenerative diseases by 2025 will increase by several hundred percent ...
Tomasz Sliwinski, Dominik Kwiatkowski
openaire +3 more sources
HMGB1 Is a Cofactor in Mammalian Base Excision Repair [PDF]
Molecular Cell, 2007 Deoxyribose phosphate (dRP) removal by DNA polymerase beta (Pol beta) is a pivotal step in base excision repair (BER). To identify BER cofactors, especially those with dRP lyase activity, we used a Pol beta null cell extract and BER intermediate as bait for sodium borohydride crosslinking.
Padmini S. Kedar +13 more
openaire +3 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
arXiv, 2015 Fine-tuned regulation of the cellular nucleotide pools is indispensable for faithful replication of DNA. The genetic information is also safeguarded by DNA damage recognition and repair processes. Uracil is one of the most frequently occurring erroneous base in DNA; it can arise from cytosine deamination or thymine-replacing incorporation.
arxiv
Automated Repair of Declarative Software Specifications in the Era of Large Language Models [PDF]
arXiv, 2023 The growing adoption of declarative software specification languages, coupled with their inherent difficulty in debugging, has underscored the need for effective and automated repair techniques applicable to such languages. Researchers have recently explored various methods to automatically repair declarative software specifications, such as template ...
arxiv
FEBS Letters, EarlyView.α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley +1 more source
Oxidized nucleotide insertion by pol β confounds ligation during base excision repair
Nature Communications, 2017 Oxidative stress in cells can lead to accumulation of reactive oxygen species and oxidation of DNA precursors. Oxidized purine nucleotides can be inserted into DNA during replication and repair.
Melike Çağlayan +4 more
semanticscholar +1 more source