Results 11 to 20 of about 967,825 (378)
Programmable C:G to G:C genome editing with CRISPR-Cas9-directed base excision repair proteins
Nature Communications, 2021 Many genetic diseases are caused by single-nucleotide polymorphisms. Base editors can correct these mutations at single-nucleotide resolution, but until recently, only allowed for transition edits, addressing four out of twelve possible DNA base ...
Liwei Chen +7 more
semanticscholar +1 more source
Dynamic features of human mitochondrial DNA maintenance and transcription
Frontiers in Cell and Developmental Biology, 2022 Mitochondria are the primary sites for cellular energy production and are required for many essential cellular processes. Mitochondrial DNA (mtDNA) is a 16.6 kb circular DNA molecule that encodes only 13 gene products of the approximately 90 different ...
Mansour Akbari +4 more
doaj +1 more source
XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair
Nature Cell Biology, 2021 Genetic defects in the repair of DNA single-strand breaks (SSBs) can result in neurological disease triggered by toxic activity of the single-strand-break sensor protein PARP1.
M. Adamowicz +8 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2021 One of the most common chronic liver disorders, affecting mainly people in Western countries, is nonalcoholic fatty liver disease (NAFLD). Unfortunately, its pathophysiological mechanism is not fully understood, and no dedicated treatment is available ...
Sylwia Ziółkowska +4 more
semanticscholar +1 more source
Resistance to Nucleotide Excision Repair of Bulky Guanine Adducts Opposite Abasic Sites in DNA Duplexes and Relationships between Structure and Function. [PDF]
PLoS ONE, 2015 The nucleotide excision repair of certain bulky DNA lesions is abrogated in some specific non-canonical DNA base sequence contexts, while the removal of the same lesions by the nucleotide excision repair mechanism is efficient in duplexes in which all ...
Zhi Liu +6 more
doaj +1 more source
Abstract OR-3: Fleeting Ensembles: Transient Protein-Protein Interactions in DNA Repair [PDF]
International Journal of Biomedicine, 2019 Background: DNA repair is a vitally important process that protects the cell’s genome from ongoing damage. Six DNA repair pathways are commonly outlined: direct reversal, base excision repair, nucleotide excision repair, mismatch repair, recombination ...
Dmitry O. Zharkov
doaj +1 more source
Cold Spring Harbor Perspectives in Biology, 2013 Base excision repair (BER) corrects DNA damage from oxidation, deamination and alkylation. Such base lesions cause little distortion to the DNA helix structure. BER is initiated by a DNA glycosylase that recognizes and removes the damaged base, leaving an abasic site that is further processed by short-patch repair or long-patch repair that largely uses
Hans E. Krokan, Magnar Bjørås
openaire +3 more sources
DNA Repair Repertoire of the Enigmatic Hydra
Frontiers in Genetics, 2021 Since its discovery by Abraham Trembley in 1744, hydra has been a popular research organism. Features like spectacular regeneration capacity, peculiar tissue dynamics, continuous pattern formation, unique evolutionary position, and an apparent lack of ...
Apurva Barve +4 more
doaj +1 more source
Nature Communications, 2022 Nucleotide excision repair proteins are involved in the repair of UV-induced DNA damage. Here, the authors show that NER proteins, DDB2, XPC, and XPA play a vital role in the 8-oxoguanine repair by coordinating with base excision repair protein OGG1.
Namrata Kumar +11 more
doaj +1 more source
Cooperation and interplay between base and nucleotide excision repair pathways: From DNA lesions to proteins [PDF]
Genetics and Molecular Biology, 2020 Base and nucleotide excision repair (BER and NER) pathways are normally associated with removal of specific types of DNA damage: small base modifications (such as those induced by DNA oxidation) and bulky DNA lesions (such as those induced by ultraviolet
Namrata Kumar +4 more
doaj +1 more source