Results 11 to 20 of about 59,740 (306)

OGG1 in Lung—More than Base Excision Repair

Antioxidants, 2022
As the organ executing gas exchange and directly facing the external environment, the lungs are challenged continuously by various stimuli, causing the disequilibration of redox homeostasis and leading to pulmonary diseases.
Xiaodi Ma, Hewei Ming, Lexin Liu, Jiahui Zhu, Lang Pan, Yu Chen, Yang Xiang   +6 more
doaj   +1 more source

DNA Repair Repertoire of the Enigmatic Hydra

Frontiers in Genetics, 2021
Since its discovery by Abraham Trembley in 1744, hydra has been a popular research organism. Features like spectacular regeneration capacity, peculiar tissue dynamics, continuous pattern formation, unique evolutionary position, and an apparent lack of ...
Apurva Barve, Apurva Barve, Alisha A. Galande, Saroj S. Ghaskadbi, Surendra Ghaskadbi   +4 more
doaj   +1 more source

Correction: PARP1 inhibitor combined with oxaliplatin efficiently suppresses oxaliplatin resistance in gastric cancer-derived organoids via homologous recombination and the base excision repair pathway. [PDF]

Front Cell Dev Biol
Li H, Wang C, Lan L, Wu W, Evans I, Ruiz EJ, Yan L, Zhou Z, Oliveira JM, Reis RL, Hu Z, Chen W, Behrens A, He Y, Zhang C.   +14 more
europepmc   +3 more sources

Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins

Nature Communications, 2022
Nucleotide excision repair proteins are involved in the repair of UV-induced DNA damage. Here, the authors show that NER proteins, DDB2, XPC, and XPA play a vital role in the 8-oxoguanine repair by coordinating with base excision repair protein OGG1.
Namrata Kumar, Arjan F. Theil, Vera Roginskaya, Yasmin Ali, Michael Calderon, Simon C. Watkins, Ryan P. Barnes, Patricia L. Opresko, Alex Pines, Hannes Lans, Wim Vermeulen, Bennett Van Houten   +11 more
doaj   +1 more source

Cooperation and interplay between base and nucleotide excision repair pathways: From DNA lesions to proteins [PDF]

Genetics and Molecular Biology, 2020
Base and nucleotide excision repair (BER and NER) pathways are normally associated with removal of specific types of DNA damage: small base modifications (such as those induced by DNA oxidation) and bulky DNA lesions (such as those induced by ultraviolet
Namrata Kumar, Natália C. Moreno, Bruno C. Feltes, Carlos FM Menck, Bennett Van Houten   +4 more
doaj   +1 more source

The Role of DNA Damage and Repair in Idiopathic Pulmonary Fibrosis

Antioxidants, 2022
The mortality rate of idiopathic pulmonary fibrosis (IPF) increases yearly due to ineffective treatment. Given that the lung is exposed to the external environment, it is likely that oxidative stress, especially the stimulation of DNA, would be of ...
Jiahui Zhu, Lexin Liu, Xiaodi Ma, Xinyu Cao, Yu Chen, Xiangping Qu, Ming Ji, Huijun Liu, Chi Liu, Xiaoqun Qin, Yang Xiang   +10 more
doaj   +1 more source

Extended Frontobasal Approach for Skull Base Lesions

Indian Journal of Neurosurgery, 2021
Background Lesions involving the skull base can be approached by a variety of surgical corridors and extended frontobasal approach is one of them. It provides quite a wide exposure to lesions in the midline of anterior skull base, paranasal sinuses, and ...
Mohd Faheem, Raj Kumar, Hanuman Prasad Prajapati   +2 more
doaj   +1 more source

Base Excision Repair

Reactome - a curated knowledgebase of biological pathways, 2004
Publisher Summary The covalent structure of the nucleobases in DNA and RNA directly provides the information for all genetic transactions. Living systems expend considerable energy in an ongoing struggle against spontaneous genetic change. The most wide-ranging threat to genetic integrity is posed by the attack of environmental agents on DNA ...
J Christopher, Fromme, Gregory L, Verdine   +1 more
openaire   +3 more sources

Mitochondrial base excision repair assays [PDF]

Methods, 2010
The main source of mitochondrial DNA (mtDNA) damage is reactive oxygen species (ROS) generated during normal cellular metabolism. The main mtDNA lesions generated by ROS are base modifications, such as the ubiquitous 8-oxoguanine (8-oxoG) lesion; however, base loss and strand breaks may also occur.
Maynard, Scott, de Souza-Pinto, Nadja C, Scheibye-Knudsen, Morten, Bohr, Vilhelm A   +3 more
openaire   +3 more sources

DNA Base Excision Repair Intermediates Influence Duplex–Quadruplex Equilibrium

Molecules, 2023
Although genomic DNA is predominantly duplex under physiological conditions, particular sequence motifs can favor the formation of alternative secondary structures, including the G-quadruplex.
Mark L. Sowers, James W. Conrad, Bruce Chang-Gu, Ellie Cherryhomes, Linda C. Hackfeld, Lawrence C. Sowers   +5 more
doaj   +1 more source