Results 31 to 40 of about 967,825 (378)
High-throughput analysis of DNA repair in microplates towards identification of inhibitors
Genes and Environment, 2020 Environmental factors can inhibit DNA repair and cause indirect mutagenic actions. Here the author introduces a recent paper on a novel high-throughput system to analyze the various enzymatic activities involved in base excision repair. Such systems will
Hiroyuki Kamiya
doaj +1 more source
Science Advances, 2017 Probing base editing outcomes leads to new C:G to T:A base editors with greater efficiency and product purity, and fewer indels. We recently developed base editing, the programmable conversion of target C:G base pairs to T:A without inducing double ...
Alexis C. Komor +8 more
semanticscholar +1 more source
Overview of Base Excision Repair Biochemistry [PDF]
Current Molecular Pharmacology, 2012 Base excision repair (BER) is an evolutionarily conserved pathway, which could be considered the "workhorse" repair mechanism of the cell. In particular, BER corrects most forms of spontaneous hydrolytic decay products in DNA, as well as everyday oxidative and alkylative modifications to bases or the sugar phosphate backbone.
David M. Wilson, Yun-Jeong Kim
openaire +3 more sources
Charge transport-mediated recruitment of DNA repair enzymes [PDF]
Journal of Chemical Physics, 129, 235101, (2008), 2008 Damaged or mismatched bases in DNA can be repaired by Base Excision Repair (BER) enzymes that replace the defective base. Although the detailed molecular structures of many BER enzymes are known, how they colocalize to lesions remains unclear. One hypothesis involves charge transport (CT) along DNA [Yavin, {\it et al.}, PNAS, {\bf 102}, 3546, (2005 ...
arxiv +1 more source
Research Advances on Base Excision Repair Factor SmuG1 and Tumor
Zhongliu Fangzhi Yanjiu, 2019 Tumor is one of the diseases that seriously threaten human health. With the deepening of research, it is found that the role of DNA damage in the occurrence and development of tumors is more and more important.
ZHENG Lijiao +3 more
doaj +1 more source
Viruses with U-DNA: New Avenues for Biotechnology
Viruses, 2021 Deoxyuridine in DNA has recently been in the focus of research due to its intriguing roles in several physiological and pathophysiological situations. Although not an orthodox DNA base, uracil may appear in DNA via either cytosine deamination or thymine ...
Kinga K. Nagy +2 more
doaj +1 more source
Eukaryotic Base Excision Repair: New Approaches Shine Light on Mechanism.
Annual Review of Biochemistry, 2019 Genomic DNA is susceptible to endogenous and environmental stresses that modify DNA structure and its coding potential. Correspondingly, cells have evolved intricate DNA repair systems to deter changes to their genetic material.
W. Beard +3 more
semanticscholar +1 more source
Accelerated search kinetics mediated by redox reactions of DNA repair enzymes [PDF]
Biophysical Journal, volume 96, pp 3949-3958, (2009), 2009 A Charge Transport (CT) mechanism has been proposed in several papers (e.g., Yavin, et al. PNAS, v102 3546 (2005)) to explain the localization of Base Excision Repair (BER) enzymes to lesions on DNA. The CT mechanism relies on redox reactions of iron-sulfur cofactors that modify the enzyme's binding affinity.
arxiv +1 more source
AIREPAIR: A Repair Platform for Neural Networks [PDF]
, 2022 We present AIREPAIR, a platform for repairing neural networks. It features the integration of existing network repair tools. Based on AIREPAIR, one can run different repair methods on the same model, thus enabling the fair comparison of different repair techniques.
arxiv +1 more source
The interplay of mutations and electronic properties in disease-related genes [PDF]
Scientific Reports 2, 272-9 (2012), 2011 Electronic properties of DNA are believed to play a crucial role in many phenomena in living organisms, for example the location of DNA lesions by base excision repair (BER) glycosylases and the regulation of tumor-suppressor genes such as p53 by detection of oxidative damage.
arxiv +1 more source