Results 41 to 50 of about 967,825 (378)
Molecules, 2022 Endonuclease III (EndoIII) is a bifunctional DNA glycosylase with specificity for a broad range of oxidized DNA lesions. The genome of an extremely radiation- and desiccation-resistant bacterium, Deinococcus radiodurans, possesses three genes encoding ...
Filipe Rollo +5 more
doaj +1 more source
Mitochondrial base excision repair assays [PDF]
Methods, 2010 The main source of mitochondrial DNA (mtDNA) damage is reactive oxygen species (ROS) generated during normal cellular metabolism. The main mtDNA lesions generated by ROS are base modifications, such as the ubiquitous 8-oxoguanine (8-oxoG) lesion; however, base loss and strand breaks may also occur.
Maynard, Scott +3 more
openaire +4 more sources
Base Sequence Context Effects on Nucleotide Excision Repair
Journal of Nucleic Acids, 2010 Nucleotide excision repair (NER) plays a critical role in maintaining the integrity of the genome when damaged by bulky DNA lesions, since inefficient repair can cause mutations and human diseases notably cancer. The structural properties of DNA lesions
Yuqin Cai +3 more
doaj +1 more source
Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice
npj Aging and Mechanisms of Disease, 2020 Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, whether CR improves
Zhonghe Ke +4 more
doaj +1 more source
Damage sensor role of UV-DDB during base excision repair
Nature Structural & Molecular Biology, 2019 UV-DDB, a key protein in human global nucleotide excision repair (NER), binds avidly to abasic sites and 8-oxo-guanine (8-oxoG), suggesting a noncanonical role in base excision repair (BER).
Sunbok Jang +14 more
semanticscholar +1 more source
Circulation, 2018 Background: Atherosclerotic plaques demonstrate extensive accumulation of oxidative DNA damage, predominantly as 8-oxoguanine (8oxoG) lesions. 8oxoG is repaired by base excision repair enzymes; however, the mechanisms regulating 8oxoG accumulation in ...
Aarti Shah +5 more
semanticscholar +1 more source
Sabiad, 2023 Objective: The purpose of this investigative research was to investigatethe potential impact of a single nucleotide polymorphism (Asp148Glu) within the APE1 gene on the development of bladder cancer (BCa) andspread, and to investigate the interaction of ...
Taghi Ahmadi Rendi +6 more
doaj +1 more source
Base excision DNA repair and cancer
Oncotarget, 2014 Transformed cells can develop drug resistance via repair mechanisms that counteract the DNA damage from chemotherapy or radiation therapy. Disruption of DNA repair pathways can cause mis-repair that is cytotoxic [1]. Specific DNA repair inhibitors might thus be combined with DNA-damaging agents for improved therapy.
Tell, G, Demple B
openaire +4 more sources
Variation in base excision repair capacity [PDF]
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2011 The major DNA repair pathway for coping with spontaneous forms of DNA damage, such as natural hydrolytic products or oxidative lesions, is base excision repair (BER). In particular, BER processes mutagenic and cytotoxic DNA lesions such as non-bulky base modifications, abasic sites, and a range of chemically distinct single-strand breaks.
Daemyung Kim +3 more
openaire +3 more sources
Journal of Cellular and Molecular Medicine, 2019 Berberine (BBR) is a natural isoquinoline alkaloid, which is used in traditional medicine for its anti‐microbial, anti‐protozoal, anti‐diarrhoeal activities.
Xingjie Gao +10 more
semanticscholar +1 more source