Results 41 to 50 of about 2,107,603 (337)
Acta Neuropathologica, 2018 Tracers injected into CSF pass into the brain alongside arteries and out again. This has been recently termed the “glymphatic system” that proposes tracers enter the brain along periarterial “spaces” and leave the brain along the walls of veins.
Nazira J. Albargothy +6 more
semanticscholar +1 more source
Journal of Medical Case Reports, 2017 Background We report a previously unrecognized and unreported case of a patient with anti-glomerular basement membrane glomerulonephritis following nintedanib, an orally active small molecule tyrosine kinase inhibitor.
Ibrahim Ismail +3 more
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Nature Communications, 2021 The basement membrane is located at tissue interfaces, but how it mediates distinct inter-tissue interactions is unclear. Here, the authors systematically define the spatial heterogeneity of skin basement membrane composition and show its functional ...
Ko Tsutsui +7 more
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The vascular basement membrane in the healthy and pathological brain
Journal of Cerebral Blood Flow and Metabolism, 2017 The vascular basement membrane contributes to the integrity of the blood-brain barrier (BBB), which is formed by brain capillary endothelial cells (BCECs).
M. S. Thomsen, L. J. Routhe, T. Moos
semanticscholar +1 more source
Nature Communications, 2017 At the stage of carcinoma in situ, the basement membrane (BM) segregates tumor cells from the stroma. This barrier must be breached to allow dissemination of the tumor cells to adjacent tissues.
Alexandros Glentis +14 more
semanticscholar +1 more source
Basement membrane collagens and disease mechanisms
Essays in Biochemistry, 2019 Basement membranes (BMs) are specialised extracellular matrix (ECM) structures and collagens are a key component required for BM function. While collagen IV is the major BM collagen, collagens VI, VII, XV, XVII and XVIII are also present.
Anna Gatseva +3 more
semanticscholar +1 more source
Disease Models & Mechanisms, 2016 Collagen IV is a major component of basement membranes, and mutations in COL4A1, which encodes collagen IV alpha chain 1, cause a multisystemic disease encompassing cerebrovascular, eye and kidney defects.
Frances E. Jones +11 more
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Anti-Glomerular Basement Membrane Disease.
American Society of Nephrology. Clinical Journal, 2017 Anti-glomerular basement membrane (anti-GBM) disease is a rare small vessel vasculitis that affects the capillary beds of the kidneys and lungs. It is an archetypic autoimmune disease, caused by the development of directly pathogenic autoantibodies ...
S. McAdoo, C. Pusey
semanticscholar +1 more source
Cell Reports, 2016 The basement membrane is crucial for cell polarity, adhesion, and motility, but how it is assembled on the cell surface remains unclear. Here, we find that ablation of glycosaminoglycan (GAG) side chains of proteoglycans in the neuroretina disrupts the ...
Chenqi Tao, Xin Zhang
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Divergent regulation of basement membrane trafficking by human macrophages and cancer cells
Nature Communications, 2022 Cancer cells and macrophages can infiltrate and remodel the extracellular matrix (ECM). Here, by using native basement membrane-interstitial matrix explants as model and live cell confocal imaging, the authors reveal divergent mechanisms used by cancer ...
Julian C. Bahr +4 more
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