Results 321 to 330 of about 282,340 (392)
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Materials Science and Engineering C: Materials for Biological Applications, 2020
In order to accelerate the healing of chronic wound, a hydrogel dressing encapsulating with heparin and basic fibroblast growth factor is prepared by the Michael addition of 4-arm acrylated polyethylene glycol and dithiothreitol.
J. Peng +9 more
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In order to accelerate the healing of chronic wound, a hydrogel dressing encapsulating with heparin and basic fibroblast growth factor is prepared by the Michael addition of 4-arm acrylated polyethylene glycol and dithiothreitol.
J. Peng +9 more
semanticscholar +1 more source
Journal of Cellular Physiology, 1991
AbstractWe have confirmed the hypothesis that a mitotoxin resulting from the conjugation of basic fibroblast growth factor and saporin exerts its cytotoxic effect through specific interaction with the basic fibroblast growth factor (FGF) receptor. Accordingly, the mitotoxin stimulates tyrosine phosphorylation of the 90 kD substrate that characterizes ...
D A, Lappi +3 more
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AbstractWe have confirmed the hypothesis that a mitotoxin resulting from the conjugation of basic fibroblast growth factor and saporin exerts its cytotoxic effect through specific interaction with the basic fibroblast growth factor (FGF) receptor. Accordingly, the mitotoxin stimulates tyrosine phosphorylation of the 90 kD substrate that characterizes ...
D A, Lappi +3 more
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The effect of basic fibroblast growth factor on scarring
British Journal of Plastic Surgery, 2002Granulation-tissue myofibroblasts are important in wound contraction, disappearing in normal scars but persisting in hypertrophic scars. While transforming growth factor beta 1 (TGF-beta 1) is implicated in excessive scarring and induces the accumulation of myofibroblasts, the role of basic fibroblast growth factor (FGF-2) on scarring remains ...
G E, Spyrou, I L, Naylor
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Basic fibroblast growth factor in Alzheimer's disease
Biochemical and Biophysical Research Communications, 1990We have examined the presence of basic fibroblast growth factor (FGF) in normal and in Alzheimer brains, studied the distribution of the mitogen by immunohistochemical techniques, measured the quantities of growth factor in selected areas of the brain (Brodmann areas 10/11 and 20/21), characterized the molecular forms by Western blotting and determined
E G, Stopa +6 more
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Complexation of basic fibroblast growth factor with gelatin
Journal of Biomaterials Science, Polymer Edition, 1998Polyion complexation between basic fibroblast growth factor (bFGF) and gelatin was studied by the turbidity change of mixed solution, heparin high performance liquid affinity chromatography (HPLAC), and isoelectric electrophoresis. When an aqueous solution of acidic gelatin with an isoelectric point (IEP) of 5.0 was mixed with that of bFGF, the ...
, Muniruzzaman, Y, Tabata, Y, Ikada
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Vitreoretinal toxicity of basic fibroblast growth factor
International Ophthalmology, 1993Basic fibroblast growth factor (b-FGF) is one of the multifunctional growth factors with important therapeutic potential in the field of ophthalmology. It is also implicated in pathogenesis of vitreoretinal proliferative diseases. In the present study, we evaluated its vitreoretinal toxicity by means of clinical observation, electroretinography (ERG ...
H, Borhani +3 more
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Basic fibroblast growth factor and ovarian cancer
The Journal of Steroid Biochemistry and Molecular Biology, 1995The factor(s) which regulate the rapid growth of ovarian epithelial carcinoma, as well as other types of malignant tumors, are still largely unknown. Recently, experimental evidence indicated that neoplastic cells are able to synthesize peptide growth factor and their receptors.
A M, Di Blasio +3 more
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Expression of acidic fibroblast growth factor and basic fibroblast growth factor in nasal polyps
Acta Oto-Laryngologica, 2006Up-regulated expression of acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF) in nasal polyps may be related to epithelial proliferation and neoangiogenesis associated with nasal polyp growth.aFGF and bFGF are polypeptides that effect mitogenesis, neoangiogenesis and tissue repair.
Hyung Jin, Kim +2 more
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Thrombin inactivates acidic fibroblast growth factor but not basic fibroblast growth factor
Biochemistry, 1988Incubation of bovine brain derived acidic fibroblast growth factor (aFGF) with bovine or human thrombin, 0.5 NIH unit/mL, for 24 h at 37 degrees C results in cleavage of the mitogen, generating a 14-kilodalton fragment which has significantly reduced affinity for immobilized heparin as compared to aFGF, and is at least 50-fold less potent at ...
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Modulation of the epidermal growth factor receptor by basic fibroblast growth factor
Journal of Cellular Physiology, 1993AbstractTreatment of Swiss 3T3 fibroblasts with basic fibroblast growth factor (bFGF) lead to a rapid reduction in epidermal growth factor (EGF) binding and a slower inhibition of EGF receptor autophosphorylation. The reduction in binding was due to a complete loss of the highest affinity EGF binding sites and a reduction in the lower affinity binding ...
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