Results 11 to 20 of about 1,506 (195)

Remibrutinib inhibits hives effector cells stimulated by serum from chronic urticaria patients independently of FcεR1 expression level and omalizumab clinical response

Clinical and Translational Allergy, 2023
Background Despite advances in the treatment of chronic urticaria, in a significant percentage of the patients symptoms are not fully controlled with conventional approaches.
Ramón Gimeno, Clara Ribas‐Llauradó, David Pesque, Evelyn Andrades, Bruno Cenni, Barbara Ambros, Ramon Pujol, Ana M. Giménez‐Arnau   +7 more
doaj   +1 more source

Blood Basophils Relevance in Chronic Rhinosinusitis with Aspirin-Exacerbated Respiratory Disease

Diagnostics, 2023
Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic asthma, chronic rhinosinusitis with nasal polyps (CRSwNP) and intolerance to cyclooxygenase-1 inhibitors.
Giuseppe Brescia, Cristoforo Fabbris, Leonardo Calvanese, Luigia Bandolin, Barbara Pedruzzi, Valerio Maria Di Pasquale Fiasca, Silvia Marciani, Francesca Mularoni, Fabio Degli Esposti Pallotti, Michael Negrisolo, Giacomo Spinato, Anna Chiara Frigo, Gino Marioni   +12 more
doaj   +1 more source

Lower IgA Levels in Chronic Spontaneous Urticaria Are Associated With Lower IgE Levels and Autoimmunity

Frontiers in Immunology, 2021
BackgroundThe pathogenesis of chronic spontaneous urticaria (CSU) is still insufficiently understood. Recent findings suggest that immunoglobulins, in particular IgE but also IgA, play a role in the development of CSU.ObjectiveOur aim was to assess ...
Merle Sauer, Merle Sauer, Jörg Scheffel, Stefan Frischbutter, Pavel Kolkhir, Pavel Kolkhir, Yi-Kui Xiang, Frank Siebenhaar, Sabine Altrichter, Marcus Maurer, Martin Metz, Karoline Krause   +11 more
doaj   +1 more source

An Evaluation of the Mechanisms of Galacto-Oligosaccharide (GOS)-Induced IgE Cross-Linking on Basophils in GOS Allergy

Frontiers in Allergy, 2022
The prebiotics, galacto-oligosaccharides (GOS), are small carbohydrate molecules with 1–7 galactose units linked to glucose and have been shown to trigger IgE-mediated anaphylaxis in some cases following ingestion.
Li Yuan Gabriella Nadine Lee, Si Yuan Leow, Hongmei Wen, Jian Yi Soh, Jian Yi Soh, Wen Chin Chiang, Youjia Zhong, Youjia Zhong, Elizabeth Huiwen Tham, Elizabeth Huiwen Tham, Wenyin Loh, Dianne J. Delsing, Bee Wah Lee, Chiung-Hui Huang   +13 more
doaj   +1 more source

An extract from the culture of a thermophilic Staphylococcus aureus strain suppresses allergic inflammation in the airways in vivo and degranulation of mast cells and basophils in vitro

Бюллетень сибирской медицины, 2023
Aim. To study the anti-allergic effects of ruzam, an extract from the culture of a thermophilic Staphylococcus aureus strain, in an in vivo model of asthma and its influence on degranulation of mast cells and basophils in vitro.Materials and methods ...
O. V. Kalyuzhin, O. V. Proskurina, S. A. Sukhanova, N. V. Novikova, N. A. Kolganova   +4 more
doaj   +1 more source

Aged mice display altered numbers and phenotype of basophils, and bone marrow-derived basophil activation, with a limited role for aging-associated microbiota

Immunity & Ageing, 2018
Background The influence of age on basophils is poorly understood, as well as the effect of aging-associated microbiota on basophils. Therefore, we studied the influence of aging and aging-associated microbiota on basophil frequency and phenotype, and ...
Adriaan A. van Beek, Floris Fransen, Ben Meijer, Paul de Vos, Edward F. Knol, Huub F. J. Savelkoul   +5 more
doaj   +1 more source

New Insights into the Roles for Basophils in Acute and Chronic Allergy

Allergology International, 2009
Basophils represent less than 1% of peripheral blood leukocytes. They are often recruited to the site of allergic inflammation, albeit in small numbers.
Kaori Mukai, Kazushige Obata, Yusuke Tsujimura, Hajime Karasuyama   +3 more
doaj   +1 more source

Basophils beyond allergic and parasitic diseases

Frontiers in Immunology, 2023
Basophils bind IgE via FcεRI-αβγ2, which they uniquely share only with mast cells. In doing so, they can rapidly release mediators that are hallmark of allergic disease.
Remo Poto, Remo Poto, Stefania Loffredo, Stefania Loffredo, Stefania Loffredo, Stefania Loffredo, Gianni Marone, Gianni Marone, Gianni Marone, Gianni Marone, Antonio Di Salvatore, Amato de Paulis, Amato de Paulis, Amato de Paulis, John T. Schroeder, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi   +18 more
doaj   +1 more source

Selective depletion of basophils ameliorates immunoglobulin E-mediated anaphylaxis

Biochemistry and Biophysics Reports, 2017
Basophils, which are the rarest granulocytes, play crucial roles in protective immunity against parasites and development of allergic disorders. Although immunoglobulin (Ig)E-dependent responses via receptor for IgE (FcεRI) in basophils have been ...
Takeshi Nakamura, Tomohiro Fukaya, Tomofumi Uto, Hideaki Takagi, Keiichi Arimura, Tetsuya Tono, Katsuaki Sato   +6 more
doaj   +1 more source

The Basoph8 Mice Enable an Unbiased Detection and a Conditional Depletion of Basophils

Frontiers in Immunology, 2019
Basophils are granulocytes involved in parasite immunity and allergic diseases, known for their potent secretion of type 2 cytokines. Identifying their functions has proven to be controversial due to their relative rarity and their complex lineage ...
Christophe Pellefigues, Palak Mehta, Melanie Sarah Prout, Karmella Naidoo, Bibek Yumnam, Jodie Chandler, Sally Chappell, Kara Filbey, Mali Camberis, Graham Le Gros   +9 more
doaj   +1 more source