Results 51 to 60 of about 53,289 (299)
Analysis of Peripheral Blood Basophils in Pediatric Systemic Lupus Erythematosus
Diagnostics, 2022 Basophils are the least abundant circulating leukocytes, and their immunological role has not yet been completely elucidated. There is evidence supporting their immunomodulatory role in several pathological settings; recently, studies in both ...
Kuanysh Dossybayeva +7 more
doaj +1 more source
Journal of Investigative Dermatology, 1962 For many, the word adventure conjures travel to distant lands or the exploration of endless outer space. I hope this afternoon to show you that adventure still exists no further away than your fingertips. This is a chronicle of the adventures we have had with a “cinderella” cell in a drop of blood.
openaire +2 more sources
Advanced Science, EarlyView.ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei +11 more
wiley +1 more source
Transient abnormal myelopoiesis with pericardial effusion in Down syndrome: Case report
Clinical Case Reports, 2019 Pericardial effusion associated with transient abnormal myelopoiesis in Down's syndrome neonates needs to be diagnosed in a timely manner, and the comorbidities must be treated to prevent mortality.
Bianca Francisco Falasco +5 more
doaj +1 more source
UDP/P2Y6 receptor signaling regulates IgE-dependent degranulation in human basophils
Allergology International, 2017 Background: P2Y purinergic receptors (P2YR) are G protein-coupled receptors that are stimulated by extracellular nucleotides. They mediate cellular effects by regulating cAMP production, protein kinase C activation, inositol trisphosphate generation, and
Manabu Nakano +7 more
doaj +1 more source
Advanced Science, EarlyView.After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang +19 more
wiley +1 more source
Differential usage of COX-1 and COX-2 in prostaglandin production by mast cells and basophils
Biochemistry and Biophysics Reports, 2017 Basophils have been erroneously considered as minor relatives of mast cells, due to some phenotypic similarity between them. While recent studies have revealed non-redundant roles for basophils in various immune responses, basophil-derived effector ...
Tomoyuki Bando +6 more
doaj +1 more source
Identification of CD203c as a New Basophil-Specific Flow-Marker in Ph+ Chronic Myeloid Leukemia
Cells, 2022 Basophilia is a crucial prognostic variable in Ph-chromosome-positive chronic myeloid leukemia (CML). The ectoenzyme CD203c is an activation-linked surface antigen that is expressed specifically on basophil-committed progenitor cells and mature basophils.
Irina Sadovnik +11 more
doaj +1 more source
Species Dependent Toxicity Comparison Outcome
Advanced Science, EarlyView.By quantitatively assessing and comparing toxicity responses across different animal species and material compositions, our data reveal that toxicity rankings among different materials may be reversed across species. ABSTRACT Toxicity comparison plays a crucial role in material selection across diverse application fields.
Lian Xiao +7 more
wiley +1 more source
Basophils and Systemic Lupus Erythematosus in Murine Models and Human Patients
Biology, 2020 Basophils are the rarest cell population in the blood. Even though basophils are known to participate in some allergic reactions and immune responses to parasitic infections, their immunological role is still largely elusive.
Kuanysh Dossybayeva +2 more
doaj +1 more source