Results 71 to 80 of about 56,684 (297)

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

IL-3 produced by T cells is crucial for basophil extravasation in hapten-induced allergic contact dermatitis

Frontiers in Immunology, 2023
Basophils have been recognized as a characterized cellular player for Th2 immune responses implicated in allergic diseases, but the mechanisms responsible for basophil recruitment to allergic skin remain not well understood.
Carole El Hachem, Pierre Marschall, Pierre Hener, Anupama Karnam, Srinivasa Reddy Bonam, Pierre Meyer, Eric Flatter, Marie-Christine Birling, Jagadeesh Bayry, Jagadeesh Bayry, Mei Li   +10 more
doaj   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Studies investigating peripheral blood derived cells that express the high affinity receptor for immunoglobulin E (Fc?RI) In Allergic Disorders

, 2008
It is just forty years since the identification of immunoglobulin E (IgE) as the reagin responsible for allergen induced immediate hypersensitivity reactions.
Sihra, Bhupinder Singh
core   +1 more source

Parallelized Immunomagnetic Isolation of Basophils Directly from Whole Blood

Advanced NanoBiomed Research
Basophils are the rarest circulating white blood cells (WBCs), but they play important roles in allergic disorders and other diseases. To enhance diagnostic capabilities, it would be desirable to isolate and analyze basophils efficiently from small blood
Justin Myles, Nicolas Castaño, Sungu Kim, Zhenyun Zhu, Sindy K.Y. Tang   +4 more
doaj   +1 more source

Balance between IL-3 and type Iinterferons and their interrelationship with FasL dictates lifespan and effector functions of human basophils. [PDF]

, 2016
BACKGROUND In contrast to eosinophils and neutrophils, the regulation of the lifespan of human basophils is poorly defined, with the exception of the potent anti-apoptotic effect of IL-3 that also promotes pro-inflammatory effector functions and ...
Hagmann, B R, Kaufmann, Thomas, Fux, Michaela, B. R. Hagmann, T. Kaufmann, C. A. Dahinden, M. Fux, Odermatt, A, A. Odermatt, Dahinden, C A   +9 more
core   +1 more source

Cytoflow: User‐Friendly Python Software for Computational Flow Cytometry

Cytometry Part A, EarlyView.
ABSTRACT Modern flow cytometry experiments routinely measure 18 or more fluorescent markers across many samples, patients, and tissues. As these experiments' complexity increases, manual gating becomes unacceptably inefficient and can introduce operator‐to‐operator variation. Computational cytometry algorithms such as unsupervised clustering, automated
Leah Teague
wiley   +1 more source

Studies investigating peripherial blood derived cells that express the high affinity receptor for immunoglobulin E (FceRI) in allergic disorders

, 2008
It is just forty years since the identification of immunoglobulin E (IgE) as the reagin responsible for allergen induced immediate hypersensitivity reactions.
Sihra, Bhupinder Singh
core   +1 more source

Double-blind placebo-controlled trial of the effect of omalizumab on basophils in chronic urticaria patients. [PDF]

, 2017
BACKGROUND Omalizumab has been shown to be effective in treating chronic spontaneous urticaria (CSU). The reduction in FcεRI receptor density on the surface of basophils and mast cells is thought to play a major role in its effectiveness. We conducted
S. Reichenbach, Jörg, Lukas, Hausmann, O, Pecaric-Petkovic, T, Pichler, W, T. Pecaric-Petkovic, O. Stalder, W. Pichler, M. Coslovsky, Reichenbach, S, Coslovsky, M, Stalder, O, L. Jörg, O. Hausmann   +13 more
core   +3 more sources