Results 81 to 90 of about 53,289 (299)

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Safety Assessment and Hypoglycemic Effect of Moringa oleifera Lam. Seed Lectin (WSMoL) in Alloxan‐Induced Diabetic Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos, Matheus Cavalcanti de Barros, Cleidiane Silva Vieira de Souza, Ryan Cristian da Silva, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia, Fernanda das Chagas Ângelo Mendes Tenório, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Robson Raion de Vasconcelos Alves, Patrícia Maria Guedes Paiva   +10 more
wiley   +1 more source

IL-3 but not monomeric IgE regulates FcεRI levels and cell survival in primary human basophils. [PDF]

, 2018
Binding of allergen-specific IgE to its primary receptor FcεRI on basophils and mast cells represents a central event in the development of allergic diseases. The high-affinity interaction between IgE and FcεRI results in permanent sensitization of these
Patrick Buschor, Clemens Andreas Dahinden, Hobi, Gabriel, Brigger, Daniel, Gabriel Hobi, Daniel Brigger, Zellweger, Fabian, Fabian Zellweger, Villiger, Peter, Buschor, Patrick, Alexander Eggel, Dahinden, Clemens A., Eggel, Alexander, Peter Matthias Villiger   +13 more
core   +1 more source

Regulation of basophil and mast cell development by transcription factors

Allergology International, 2016
Basophils and mast cells play important roles in host defense against parasitic infections and allergic responses. Several progenitor populations, either shared or specific, for basophils and/or mast cells have been identified, thus elucidating the ...
Haruka Sasaki, Daisuke Kurotaki, Tomohiko Tamura   +2 more
doaj   +1 more source

Lipid Interference Flagging and Haemoglobin Correction in Lipemic Samples With a Hematology Analyzer

Journal of Clinical Laboratory Analysis, EarlyView.
A flagging method was developed based on the changes of routine blood parameters and blood cell scattergram. It highlights the clinical value of the “Lipid Particles?” flag in effectively identifying lipid interference. This study supports the use of HGB‐O measured by ERP channel as a robust tool for improving diagnostic accuracy in lipid interference ...
Yinhua Fan, Yimin Shen, Dongmei Liu, Yong Wang, Jun Cao, Bo Zhao, Yushuai Ma, Zijie Chen, Shuaishuai Zhang   +8 more
wiley   +1 more source

Basophils enhance immunological memory responses

, 2008
The cellular basis of immunological memory remains a controversial issue. Here we show that basophils bound large amounts of intact antigens on their surface and were the main source of interleukins 6 and 4 in the spleen and bone marrow after ...
Leoni A Kunz-Schughart, Maus, Ulrich A, Maus, Regina, David E Briles, Moll, Cordula, Yvonne Talke, Briles, David E, Susan Hollingshead, Talke, Yvonne, Marianne Niedermeier, Ulrich A Maus, Winter, Christine, Manuel Rodriguez Gomez, Regina Maus, Andrea Denzel, Christine Winter, Denzel, Andrea, Gomez, Manuel Rodriguez, Cordula Moll, Hollingshead, Susan, Mack, Matthias, Kunz-Schughart, Leoni A, Niedermeier, Marianne, Matthias Mack   +23 more
core   +1 more source

Age‐Associated Variations in Complete Blood Cell Count Parameters and Derived Indices Among Community‐Dwelling Chinese Older Adults

Journal of Clinical Laboratory Analysis, EarlyView.
This cross‐sectional study analyzed data from 9331 participants aged 24–97 to characterize age‐ and sex‐related physiological trajectories of complete blood cell count (CBC) parameters and derived inflammatory indices. Key findings encompassed age‐related declines in red blood cell and platelet counts, elevations in RDW‐CV indices and monocyte ...
Xiangyi Ma, Na Liu, Xiang Wu, Qiudan Chen, Xiaotong Chen, Qingyu Zhou, Shuying Chen, Yong Lin, Xuefeng Wang   +8 more
wiley   +1 more source

Retroviral transduction in cultured murine basophils

, 2015
<p>Basophils are one of effector cells in type 2 immune responses that critically are associated with allergic inflammation and infections with helminth parasites.
sprotocols
core   +1 more source

Disentangling Temporal and Environmental Effects on Hematological Values in Prairie Rattlesnakes (Crotalus viridis)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Hematologic assessment is a common clinical tool used to characterize both individual and population health. In ectothermic organisms, the hematologic response is influenced by external factors such as temperature and season, especially in temperate species. Yet, specific environmental effects have received little direct attention.
Ethan J. Kessler, Sarah J. Baker, Ellen Haynes, Amy N. Schnelle, Matthew C. Allender   +4 more
wiley   +1 more source

Basophils promote innate lymphoid cell responses in inflamed skin.

, 2014
Type 2 inflammation underlies allergic diseases such as atopic dermatitis, which is characterized by the accumulation of basophils and group 2 innate lymphoid cells (ILC2s) in inflamed skin lesions.
Wang, Kelvin, Noti, Mario, Artis, David, Kim, Brian S, Saenz, Steven A, Brestoff, Jonathan R, Tait Wojno, Elia D, Siracusa, Mark C, Fung, Thomas C, Monticelli, Laurel A, Kubo, Masato   +10 more
core   +1 more source