Results 61 to 70 of about 1,506 (195)

Applying Surface Plasmon Resonance to Monitor the IgE-Mediated Activation of Human Basophils

Allergology International, 2008
Background: The histamine releasing test which detects histamine released from basophils in vitro is safe, sensitive and widely used for clinical examination in the field of allergy.
Hidenori Suzuki, Yuhki Yanase, Tomoko Tsutsui, Kaori Ishii, Takaaki Hiragun, Michihiro Hide   +5 more
doaj   +1 more source

When is a mouse basophil not a basophil?

Blood, 2006
AbstractThe identification and characterization of mouse basophils have historically been hampered by the extreme rarity of this cell type. Virtually no photomicrographs of hematologically stained (eg, Wright-Giemsa) examples of mouse basophils exist in the literature. However, 4 recent studies in the past 2 years have used flow cytometry and a defined
James J, Lee, Michael P, McGarry
openaire   +3 more sources

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Exercise affects systemic basophil responses in humans: Applying an automated and modified basophil activation test (mBAT) in a field study

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Basophils are effector cells in type I hypersensitivity reactions. Upon cross‐linking of surface‐bound (allergen‐specific) IgE, basophils release a variety of mediators. Determining the activation of basophils ex vivo with anti‐IgE (a basophil activation test or BAT) can be achieved using flow cytometry.
T. C. Pelgrim, B. N. Jukema, L. Koopmans, C. C. W. G. Bongers, M. T. E. Hopman, E. F. Knol, N. Vrisekoop, L. Koenderman   +7 more
wiley   +1 more source

Autologous Extracellular Matrix‐Based Cell‐Free Therapy for Tissue Regeneration Through Trem2+ Macrophages Mediated Angiogenesis

Exploration, EarlyView.
ADF is prepared as a cell‐free bio‐membrane from autologous adipose ECM using simple physical techniques inspired by “papermaking”. It boasts superior properties and facilitates tissue regeneration through Trem2+ macrophages‐mediated angiogenesis. ADF can be stored long‐term for personalized medicine, offering insights into autologous ECM preservation ...
Mengmeng Hou, Nini Shi, Yajie Guo, Jiezhang Tang, Han Peng, Baoyan Liang, Yixuan Yu, Chenggang Yi, Huichen Li   +8 more
wiley   +1 more source

Regulation of basophil and mast cell development by transcription factors

Allergology International, 2016
Basophils and mast cells play important roles in host defense against parasitic infections and allergic responses. Several progenitor populations, either shared or specific, for basophils and/or mast cells have been identified, thus elucidating the ...
Haruka Sasaki, Daisuke Kurotaki, Tomohiko Tamura   +2 more
doaj   +1 more source

THE HEMIC BASOPHIL [PDF]

Journal of Experimental Medicine, 1920
1. The basophilic granule of blood and marrow cells does not show the brown color reaction with benzidine solutions that is characteristic of the neutrophilic and eosinophilic granules. It differs from these types also in other important microchemical and physical particulars. 2.
openaire   +2 more sources

Unveiling CLC as a Central Regulator of Allergic Rhinitis via the CLC‐CCL26/POSTN Axis: An Integrated Bioinformatics and Experimental Study

Flavour and Fragrance Journal, EarlyView.
We unveil that CLC orchestrates the dual role of eosinophil recruitment via CCL26 and tissue remodelling via POSTN in allergic rhinitis, identifying it as a potential therapeutic target. ABSTRACT Allergic rhinitis (AR) is a chronic airway inflammation driven by a type 2 immune response, yet the molecular mechanisms underlying its persistence and tissue
Fanyu Yuan, Yuhan Dong, Zishuo Guo, Xiaodong Zhao, Jian Liu, Fangyuan Zhu, Shengjie Ge, Chengcheng Liu, Shuai Xu, Ming Xia   +9 more
wiley   +1 more source

A Machine Learning Model Based on Blood Indices for the Differential Diagnosis of Colorectal Cancer and Colorectal Polyps

iLABMED, EarlyView.
This diagram systematically sorts out the complete data processing pipeline, clearly presenting the key links and logical connections from raw data collection, preprocessing (including cleaning, deduplication, format standardization, etc.), and core computational analysis to the result output.
Wenhui Yan, Lin Zhu, Hongming Wei, Jie Feng, Yanhong Gao   +4 more
wiley   +1 more source