Correction: Shi et al. ATF3 Promotes Arsenic-Induced Apoptosis and Oppositely Regulates DR5 and Bcl-xL Expression in Human Bronchial Epithelial Cells. <i>Int. J. Mol. Sci.</i> 2021, <i>22</i>, 4223. [PDF]
Int J Mol SciShi Q, Hu B, Yang C, Zhao L, Wu J, Qi N.
europepmc +1 more source
Chromosome instability functions as a potential therapeutic reference by enhancing chemosensitivity to BCL-XL inhibitors in colorectal carcinoma. [PDF]
Acta Pharmacol SinFang X +9 more
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Statement of Retraction: Upregulation of miR-140-5p uncouples mitochondria by targeting Bcl-xL in vascular smooth muscle cells in angiotensin II-induced hypertension. [PDF]
Bioengineeredeuropepmc +1 more source
MDM2-BCL-XL PROTACs enable degradation of BCL-XL and stabilization of p53
Acta Materia Medica, 2022 Inhibition or degradation of the anti-apoptotic protein BCL-XL is a viable strategy for cancer treatment. Despite the recent development of PROTACs for degradation of BCL-XL, the choice of E3 ligase has been restricted to VHL and CRBN.
Mengyang Chang +4 more
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Allosteric regulation of BH3-in-groove interactions by tail anchors of BCL-xL complexes limits BH3 mimetic antagonism [PDF]
Nature CommunicationsBCL-xL promotes cell survival by binding BH3-only initiators through its hydrophobic groove. Combining resonance energy transfer assays and molecular dynamics simulations, we unravel that membrane anchoring of BCL-xL via its tail anchor selectively ...
Laurent Maillet +8 more
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The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition [PDF]
BMC Cancer, 2012 Background It has been shown in many solid tumors that the overexpression of the pro-survival Bcl-2 family members Bcl-xL and Mcl-1 confers resistance to a variety of chemotherapeutic agents.
Peddaboina Chander +10 more
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BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress [PDF]
Nature CommunicationsBH3 mimetic drugs that inhibit BCL-2, BCL-XL, or MCL-1 have limited activity in solid tumors. Through assessment of xenograft-derived 3D prostate cancer models and cell lines we find that tumors with RB1 loss are sensitive to BCL-XL inhibition.
Andreas Varkaris +31 more
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ΔN-Bcl-xL, a therapeutic target for neuroprotection
Neural Regeneration Research, 2017 The B-cell lymphoma-extra large (Bcl-xL) is a mitochondrial anti-apoptotic protein that plays a role in neuroprotection. However, during excitotoxic stimulation, Bcl-xL undergoes caspase-dependent cleavage and produces a fragmented form, ΔN-Bcl-xL ...
Han-A Park, Elizabeth A Jonas
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Evaluation of Bak and Bcl-Xl gene expression among pediatric patients with acute primary immune thrombocytopenia [PDF]
Clinical and Experimental PediatricsBackground Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet counts and an increased risk of bleeding. Moreover, the apoptotic mechanisms of platelets may influence their production and lifespan.
Amira Zaki Badawy +6 more
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