Bcl-XL inhibits membrane permeabilization by competing with Bax. [PDF]
PLoS Biology, 2008 Although Bcl-XL and Bax are structurally similar, activated Bax forms large oligomers that permeabilize the outer mitochondrial membrane, thereby committing cells to apoptosis, whereas Bcl-XL inhibits this process. Two different models of Bcl-XL function
Lieven P Billen +4 more
doaj +8 more sources
MDM2-BCL-XL PROTACs enable degradation of BCL-XL and stabilization of p53
Acta Materia Medica, 2022 Inhibition or degradation of the anti-apoptotic protein BCL-XL is a viable strategy for cancer treatment. Despite the recent development of PROTACs for degradation of BCL-XL, the choice of E3 ligase has been restricted to VHL and CRBN.
Mengyang Chang +4 more
doaj +3 more sources
Differential dependence on Beclin 1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal cancer cells. [PDF]
PLoS ONE, 2010 Autophagy is described to be involved in homeostasis, development and disease, both as a survival and a death process. Its involvement in cell death proceeds from interrelationships with the apoptotic pathway.
Muriel Priault +5 more
doaj +7 more sources
Nutritional Regulators of Bcl-xL in the Brain [PDF]
Molecules, 2018 B-cell lymphoma-extra large (Bcl-xL) is an anti-apoptotic Bcl-2 protein found in the mitochondrial membrane. Bcl-xL is reported to support normal brain development and protects neurons against toxic stimulation during pathological process via its roles ...
Han-A Park +4 more
doaj +4 more sources
ΔN-Bcl-xL, a therapeutic target for neuroprotection
Neural Regeneration Research, 2017 The B-cell lymphoma-extra large (Bcl-xL) is a mitochondrial anti-apoptotic protein that plays a role in neuroprotection. However, during excitotoxic stimulation, Bcl-xL undergoes caspase-dependent cleavage and produces a fragmented form, ΔN-Bcl-xL ...
Han-A Park, Elizabeth A Jonas
doaj +4 more sources
Adenovirus-mediated siRNA targeting Bcl-xL inhibits proliferation, reduces invasion and enhances radiosensitivity of human colorectal cancer cells [PDF]
World Journal of Surgical Oncology, 2011 Introduction Bcl-xL, an important member of anti-apoptotic Bcl-2 family, plays critical roles in tumor progression and development. Previously, we have reported that overexpression of Bcl-xL was correlated with prognosis of colorectal cancer (CRC ...
Lv Chengyu +5 more
doaj +5 more sources
Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line [PDF]
BMC Cancer, 2006 Background Bcl-2 and Bcl-XL are anti-apoptotic paralogues that inhibit apoptosis elicited by a wide variety of stimuli, and play critical roles in cancer development and resistance to treatment.
Leber Brian +4 more
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Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin [PDF]
Oncotarget, 2015 High-grade conventional osteosarcoma is the most common primary bone tumor. Prognosis for osteosarcoma patients is poor and resistance to chemotherapy is common.
Baranski, Madrigal Z. +8 more
core +9 more sources
Bcl-xL as a Modulator of Senescence and Aging [PDF]
International Journal of Molecular Sciences, 2021 Many features of aging result from the incapacity of cells to adapt to stress conditions. When cells are overwhelmed by stress, they can undergo senescence to avoid unrestricted growth of damaged cells. Recent findings have proven that cellular senescence is more than that.
Cristina Mas-Bargues +2 more
openaire +6 more sources
Oxidative stress battles neuronal Bcl-xL in a fight to the death
Neural Regeneration Research, 2021 Bcl-xL is a pro-survival protein of the Bcl2 family found in the mitochondrial membrane. Bcl-xL supports growth, development, and maturation of neurons, and it also prevents neuronal death during neurotoxic stimulation.
Han-A Park +2 more
doaj +1 more source